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| 1 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Detection of a novel porcine boca-like virus in the background of porcine circovirus type 2 induced postweaning multisystemic wasting syndrome显示文摘 | Anne-Lie Blomstr?m Sandor Belák Caroline Fossum John McKillen Gordon Allan Per Wallgren Mikael Berg | 2009 | Virus Research2009，，1： | 1 |
| 4 | Tenderness-An enzymatic view显示文摘 | Caroline M K Paul L S Ronald G B | 2010 | Meat Science2010，84，： | 1 |
| 5 | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients显示文摘 | Hans Dieter Nischalke Cordula Berger Carolin Luda Tobias Müller Thomas Berg Martin Coenen Benjamin Kr?mer Christian K?rner Jonel Trebicka Frank Grünhage Frank Lammert Jacob Nattermann Tilman Sauerbruch Ulrich Spengler | 2011 | Journal of Hepatology2011，，4： | 1 |
| 6 | Comparing uncertain alternatives for a possible airport island location in the North Sea显示文摘 | Caroline S K Suzanne J M H H Teunis L | 2003 | Ocean & Coastal Management2003，46，1112： | 1 |
| 7 | Evaluation of response to fractionated radioimmunotherapy with 90Y-epratuzumab in non-Hodgkin's lymphoma by 18F-fluorodeoxyglucose positron emission tomography显示文摘 | Caroline B M Francoise K B Benoit D | 2008 | Haematologica2008，93，3： | 1 |
| 8 | Recycling of manure nutrients:use of algal biomass from dairy manure treatment as a slow release fertilizer显示文摘 | Walter M Elizabeth K W Carolins P | 2005 | Bioresource Technology2005，96，4： | 1 |
| 9 | Effects of foot- and-mouth disease virus nonstructural proteins on the structure and function of the early secretory pathway: 2BC but not 3A blocks endoplasmic reticulum-to-golgi transport显示文摘 | KATY M GARETH H CAROLINE K | 2005 | J Virol2005，79，7： | 1 |
| 10 | The changing risk of Plasmodium falciparum malaria infection in Africa: 2000–10: a spatial and temporal analysis of transmission intensity显示文摘 | Abdisalan M Noor Damaris K Kinyoki Clara W Mundia Caroline W Kabaria Jonesmus W Mutua Victor A Alegana Ibrahima Socé Fall Robert W Snow | 2014 | The Lancet2014，，： | 1 |
| 11 | Marked regression of metastatic pilocytic astrocytoma during treatment with lmatinib Mesylate(STI571)显示文摘 | Margaret E M Caroline D R Mark W K | 2003 | Pediatr Hematol Oncol2003，25，8： | 1 |
| 12 | Previous induced abortion and the risk of very preterm delivery:resuits of the EPIPAGE study 显示文摘 | CAROLINE M MONIQUE K JEAN B | 2005 | International J of Obstet and Gynaecol2005，112，4： | 1 |
| 13 | Alteration of gibberellin response in transgenic tobacco plants which express a human Lewis fucosyltransferase显示文摘 | Caroline J Abderrahman M Catherine R K | | 0，，： | 1 |
| 14 | Jasmonate biosynthesis in arabidopsis thaliana requires peroxisomal 13-oxidation enzymes-additional proof by properties in arabidopsis thaliana requires peroxisomal 13-oxidation enzymes-additional proof by properties of pex6 and aiml 显示文摘 | CAROLIN D BETHANY K Z OTTO M | 2007 | Phytochemistry2007，68，12： | 1 |
| 15 | Previous induced abortion and the risk of very preterm delivery:results of the EPIPAGE study显示文摘 | Caroline M Monique K Jean B | 2005 | Int J Obstet Gynaecol2005，112，4： | 1 |
| 16 | Equity and repurchase intention following service failure显示文摘 | Adrian P Rosalind B Caroline K M | 2000 | Journal of Services Marketing2000，6，： | 1 |
| 17 | Relevance of visual and olfacto- ry cues for host location in the mustard leaf beetle Phaedon cochleariae 显示文摘 | Anne K Caroline M | 2011 | Physiological Entomology2011，36，1： | 1 |
| 18 | Comparing uncertain alternatives for a possible airport island location in the North Sea 显示文摘 | CAROLINE S K SUZANNE J M H H TEUNIS L | 2003 | Ocean & Coastal Management2003，46，1112： | 1 |
| 19 | Tne role of aimulation in nurse education显示文摘 | Caroline S M Marian K T | 2010 | Nurse Education Today2010，，30： | 1 |
| 20 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II):an open-label randomized trial 显示文摘 | CAROLINE H K PAUL M L JOLANDA V | 2010 | Lancet2010，376，9746： | 1 |
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