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| 1 | Hepatocellular carcinoma: Advances in diagnosis, management, and long term outcome显示文摘Hepatocellular carcinoma(HCC) remains a common and lethal malignancy worldwide and arises in the setting of a host of diseases. The incidence continues to increase despite multiple vaccines and therapies for viruses such as the hepatitis B and C viruses. In addition, due to the growing incidence of obesity in Western society, there is anticipation that there will be a growing population with HCC due to non-alcoholic fatty liver disease. Due to the growing frequency of this disease, screening is recommended using ultrasound with further imaging using magnetic resonance imaging and multi-detector computed tomography used for further characterization of masses. Great advances have been made to help with the early diagnosis of small lesions leading to potential curative resection or transplantation. Resection and transplantation maybe used in a variety of patients that are carefully selected based on underlying liver disease. Using certain guidelines and clinical acumen patients may have good outcomes with either resection or transplantation however many patients are inoperable at time of presentation. Fortunately, the use of new locoregional therapies has made down staging patients a potential option making them potential surgical candidates. Despite a growing population with HCC, new advances in viral therapies, chemotherapeutics, and an expanding population of surgical and transplant candidates might all contribute to improved long-term survival of these patients. | Adam S Bodzin Ronald W Busuttil | 2015 | World Journal of Hepatology2015，7，9： | 22 |
| 2 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 3 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 4 | Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation显示文摘Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, how ever, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients. | Keri E Lunsford Adam S Bodzin Diego C Reino Hanlin L Wang Ronald W Busuttil | 2016 | World Journal of Gastroenterology2016，22，45： | 3 |
| 5 | Myc Family Oncogenes in the Development of Normal and Neoplastic Cell显示文摘 | Ronald A D Nicole S A Fredrck W A | 1991 | Adv Cancer Res1991，57，： | 1 |
| 6 | Quantitative monitoring of gene expression patters with a complementary DNA microarray显示文摘 | Schena M Dari S Ronald W | 1995 | Science1995，270，： | 1 |
| 7 | Phenolics of apple pear and white grape juice and their changes with processing and storage review显示文摘 | Geogre A S Ronald E W | 1992 | Agric Food Chert1992，，40： | 1 |
| 8 | A Coarse/Fine Search PN Code Acquisition Scheme显示文摘 | Adam C V Ronald D W Maximo H S | 2001 | IEEE Transactions on Aerospace and Electronic Systems2001，37，1： | 1 |
| 9 | 7 regulation of the yeast general amino acid control pathway in response to nutrient stress显示文摘 | Ronald C W Kirk A S Jana N | 2004 | Topics in Current Genetics2004，7，： | 1 |
| 10 | Phenolics of apple,pear,and white grape juice and their changes with processing and storage-a review显示文摘 | RONALD E W | 1992 | J Agric Food Chem1992，，14： | 1 |
| 11 | Genetic algorithm-based method for selecting wavelengths and model size for use with partial least-squares regression:Application to near-infrared spectroscopy显示文摘 | Bangalore Arjun S Shaffer Ronald E Small Gary W | 1996 | Analytical Chemistry1996，68，23： | 1 |
| 12 | Prevalence of complications of male circumcision in Anglophone Africa: a systematic review显示文摘 | Adamson S M Hans W P Ronald H M | 2007 | BMC Urol2007，7，4： | 1 |
| 13 | Cross-resistance of a large crabgrass ( Digitaria sanguinalis ) accessions to aryloxyphenoxypropionate and cyclohexanedione herbicides 显示文摘 | Ronald J W David E S | 1995 | Weed Technology1995，9，： | 1 |
| 14 | Recent advances in understanding lidnin biosynthesis显示文摘 | Ross W W John J M Ronald R S | 1998 | Annual Review of Plant Physiology and Plant Molecular Biology1998，49，： | 1 |
| 15 | Public infrastructure and private productivity:a stochastic-frontier approach显示文摘 | CHARLES D D HERBERT T RONALD S W | 1999 | J of Economies1999，21，3： | 1 |
| 16 | A Study of the Separation Principle in Size Exclusion Chromatography显示文摘 | Thomas S Ronald C R William G W | 2004 | Macromolecules2004，37，11： | 1 |
| 17 | Genomics of forest and ecosystem health in the Fagaceae: Meeting report 显示文摘 | Antoine K Ronald S Nicholas W | 2010 | Tree Ge- netics & Genomes2010，6，： | 1 |
| 18 | Use ofFusarium graminearum trans- formed with gfp to follow infection patterns in barley and Arabidopsis显示文摘 | RONALD W S THOMAS M H | 2004 | Physiological and Molecular Plant Pathology2004，64，1： | 1 |
| 19 | Immunophenotypic and molecular features, clinical outcomes, treatments, and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma, a systematic analysis of 156 patients reported in the literature 显示文摘 | Ronald S G Susan M W | 2004 | Cancer2004，101，6： | 1 |
| 20 | Functional amino acids and fatty acids for enhancing production performance of sows and piglets显示文摘 | Kim S W Ronald D M Yin Y L | 2007 | Asian-Aust J Anita Sci2007，，20： | 1 |
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