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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Hepatitis B and C infection and liver disease trends among human immunodeficiency virus-infected individuals显示文摘AIM:To examine trends in and correlates of liver disease and viral hepatitis in an human immunodeficiency virus (HIV)-infected cohort. METHODS:The multi-site adult/adolescent spectrum of HIV-related diseases (ASD) followed 29 490 HIVinfected individuals receiving medical care in 11 U.S. metropolitan areas for an average of 2.4 years,and a total of 69 487 person-years,between 1998 and 2004. ASD collected data on the presentation,treatment,and outcomes of HIV,including liver disease,hepatitis screening,and hepatitis diagnoses. RESULTS:Incident liver disease,chronic hepatitis B virus (HBV),and hepatitis C virus (HCV) were diagnosed in 0.9,1.8,and 4.7 per 100 person-years. HBV and HCV screening increased from fewer than 20% to over 60% during this period of observation (P < 0.001). Deaths occurred in 57% of those diagnosed with liver disease relative to 15% overall (P < 0.001). Overall 10% of deaths occurred among individuals with a diagnosis of liver disease. Despite care guidelines promoting screening and vaccination for HBV and screening for HCV,screening and vaccination were not universally conducted or,if conducted,not documented. CONCLUSION:Due to high rates of incident liver disease,viral hepatitis screening,vaccination,and treatment among HIV-infected individuals should be a priority. | Susan E Buskin Elizabeth A Barash John D Scott David M Aboulafia Robert W Wood | 2011 | World Journal of Gastroenterology2011，17，14： | 2 |
| 3 | Valuing the recreational benefits from the creation of nature reserves in irish forests 显示文摘 | RICCARDO S SUSAN M C HUTCHINSON W G | 2000 | Ecological Economics2000，33，2： | 1 |
| 4 | Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells显示文摘 | Nalinie S W Tissa T M Susan M D | 2009 | Nucleic Acids Res2009，37，8： | 1 |
| 5 | The greater omentum 显示文摘 | Susan W S Robert E M Paul M S | 1997 | AJR1997，168，3： | 1 |
| 6 | The Role of Consumers' Intuitions in Inference Making 显示文摘 | Broniarczyk Susan M Josehp W Alba | 1994 | Journal of Consumer Research1994，21，11： | 1 |
| 7 | 16 S ribosomal DNA amplification for phylogenetic study显示文摘 | Willian G W Susan M B Dale A P | 1991 | J Bacteriol1991，173，2： | 1 |
| 8 | Metabolism and disposition of bisphenol A in female rats显示文摘 | RODNEY W S SUSAN C M KEVIN W G | 2000 | Toxicol Appl Pharmacol2000，168，3： | 1 |
| 9 | 16S ribosomal DNAamplification for phylogenetic study显示文摘 | William G W Susan M B Dale A P | 1991 | Journal of Bacteriology1991，173，2： | 1 |
| 10 | 16S Ribosomal DNA amplification for phylogenetic study显示文摘 | William G W Susan M B Dale A | 1991 | J Bacteriol1991，173，2： | 1 |
| 11 | Military application of agent-based simulation显示文摘 | Thomas M Cioppa Thomas W Lucas Susan M Sanchez | 2004 | WSC2004，2004，： | 1 |
| 12 | Three-Dimensional Finite Element Analyses of Embedded Retaining Walls Supported by Discontinuous Earth Berms显示文摘 | Susan M Powrie W | 2000 | Canadain Geotechnical Journal2000，，10： | 1 |
| 13 | 16S ribosomal DNA ampli- fication for phylogenetic study 显示文摘 | William G W Susan M B Dale A P | 1991 | Journal of Bacteriology1991，173，2： | 1 |
| 14 | Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons显示文摘 | Susan O McGuire Zao Dung Ling Jack W Lipton Caryl E Sortwell Timothy J Collier Paul M Carvey | 2001 | Experimental Neurology2001，，2： | 1 |
| 15 | 16S ribosomal DNA amplification for phylogenetic study显示文摘 | William G W Susan M B Dale A P | 1991 | Journal of Bacteriology1991，1，： | 1 |
| 16 | An evaluation of ecotourism in Amazonas, Brazil 显示文摘 | George N W Susan M P | 1996 | Annals of Tourism Research1996，23，4： | 1 |
| 17 | A one model approach to congestion in data envelopment analysis 显示文摘 | COOPER W W DENG HONGHUI HUANG ZHIMIN M LI SUSAN X | 2002 | Socio - Economic Planning Sciences2002，，36： | 1 |
| 18 | Immunophenotypic and molecular features, clinical outcomes, treatments, and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma, a systematic analysis of 156 patients reported in the literature 显示文摘 | Ronald S G Susan M W | 2004 | Cancer2004，101，6： | 1 |
| 19 | 16S ribosomal DNA amplification for phylogenetic study显示文摘 | Wiliam G W Susan M B Dale A P | 1991 | J Bacteriol1991，173，： | 1 |
| 20 | Cir- cadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy 显示文摘 | BROOKE H M SUSAN L O FRED W T | 2004 | Curt Biol2004，14，： | 1 |
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