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| 1 | The CAMS Climate System Model and a Basic Evaluation of Its Climatology and Climate Variability Simulation显示文摘A new coupled climate system model(CSM) has been developed at the Chinese Academy of Meteorological Sciences(CAMS) by employing several state-of-the-art component models. The coupled CAMS-CSM consists of the modified atmospheric model [ECmwf-HAMburg(ECHAM5)], ocean model [Modular Ocean Model(MOM4)], sea ice model [Sea Ice Simulator(SIS)], and land surface model [Common Land Model(CoLM)]. A detailed model description is presented and both the pre-industrial and 'historical' simulations are preliminarily evaluated in this study.The model can reproduce the climatological mean states and seasonal cycles of the major climate system quantities,including the sea surface temperature, precipitation, sea ice extent, and the equatorial thermocline. The major climate variability modes are also reasonably captured by the CAMS-CSM, such as the Madden–Julian Oscillation(MJO), El Ni?o–Southern Oscillation(ENSO), East Asian Summer Monsoon(EASM), and Pacific Decadal Oscillation(PDO).The model shows a promising ability to simulate the EASM variability and the ENSO–EASM relationship. Some biases still exist, such as the false double-intertropical convergence zone(ITCZ) in the annual mean precipitation field,the overestimated ENSO amplitude, and the weakened Bjerknes feedback associated with ENSO; and thus the CAMS-CSM needs further improvements. | Xinyao RONG Jian LI Haoming CHEN Yufei XIN Jingzhi SU Lijuan HUA Tianjun ZHOU Yanjun QI Zhengqiu ZHANG Guo ZHANG Jianduo LI | 2018 | Journal of Meteorological Research2018，32，6： | 15 |
| 2 | Treatment of coke plant wastewater by A/O fixed biofilm system显示文摘Coke plant wastewater was treated by an anaerobic–aerobic (A/O) biofilm system. A lab-scale experiment, during which semi-soft media were packed in both the anaerobic and the aerobic reactors, was carried out. The influence parameters, such as HRT, C/N ratio, OLR, and the recycling flow rate on the performance of the system, were studied. The results showed that a sufficient carbon source was important to the performance of bio-degradation system. The COD removal rate increased from 64.15% to 83.28% by raising C/N in wastewater from 2.5 (no ex-ternal carbon source) to 5. But the effluent COD concentration was still a little higher than the discharge standard. In order to make it meet the discharge standard, a deep treatment, coagula-tion, was applied, which was proved as an effective method. Then the effluent COD concentra-tion can be brought to lower than 200 mg·L?1. The NH4-N removal rate in this system was sat-isfactory, being higher than 99%. In addition, it was almost not affected by both C/N ratio and coagulation treatment. The results show that the system is feasible to treat coke plant wastewa-ter. | YU Zhaoxiang QI Rong YIN Yanjun | 2005 | Science China Chemistry2005，48，5： | 8 |
| 3 | Characterization of mechanical properties of aluminum cast alloy at elevated temperature显示文摘The tensile response, the low cycle fatigue(LCF) resistance, and the creep behavior of an aluminum(Al) cast alloy are studied at ambient and elevated temperatures.A non-contact real-time optical extensometer based on the digital image correlation(DIC)is developed to achieve strain measurements without damage to the specimen. The optical extensometer is validated and used to monitor dynamic strains during the mechanical experiments. Results show that Young's modulus of the cast alloy decreases with the increasing temperature, and the percentage elongation to fracture at 100℃ is the lowest over the temperature range evaluated from 25℃ to 300℃. In the LCF test, the fatigue strength coefficient decreases, whereas the fatigue strength exponent increases with the rising temperature. The fatigue ductility coefficient and exponent reach maximum values at 100℃. As expected, the resistance to creep decreases with the increasing temperature and changes from 200℃ to 300℃. | Shuiqiang ZHANG Yichi ZHANG Ming CHEN Yanjun WANG Quan CUI Rong WU D.AROLA Dongsheng ZHANG | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，7： | 4 |
| 4 | Boreal Summer Intraseasonal Oscillation in the Asian–Pacific Monsoon Region Simulated in CAMS-CSM显示文摘The boreal summer intraseasonal oscillation(BSISO) is simulated by the Climate System Model(CSM) developed at the Chinese Academy of Meteorological Sciences(CAMS), China Meteorological Administration. Firstly, the results indicate that this new model is able to reasonably simulate the annual cycle and seasonal mean of the precipitation, as well as the vertical shear of large-scale zonal wind in the tropics. The model also reproduces the eastward and northward propagating oscillation signals similar to those found in observations. The simulation of BSISO is generally in agreement with the observations in terms of variance center, periodicity, and propagation, with the exception that the magnitude of BSISO anomalous convections are underestimated during both its eastward propagation along the equator and its northward propagation over the Asian–Pacific summer monsoon region. Our preliminary evaluation of the simulated BSISO by CAMS-CSM suggests that this new model has the capability, to a certain extent, to capture the BSISO features, including its propagation zonally along the equator and meridionally over the Asian monsoon region. | Yanjun QI Renhe ZHANG Xinyao RONG Jian LI Lun LI | 2019 | Journal of Meteorological Research2019，33，1： | 2 |
| 5 | A Carboxymethyl Cellulase from a Marine Yeast(Aureobasidium pullulans 98): Its Purification, Characterization, Gene Cloning and Carboxymethyl Cellulose Digestion显示文摘We have reported that A. pullulans 98 produces a high yield of cellulase. In this study, a carboxymethyl cellulase(CMCase) in the supernatant of the culture of A. pullulans 98 was purified to homogeneity, and the maximum production of CMCase was 4.51 U(mg protein)-1. The SDS-PAGE analysis showed that the molecular mass of the purified CMCase was 67.0 k Da. The optimal temperature of the purified enzyme with considerable thermosensitivity was 40℃, much lower than that of the CMCases from other fungi. The optimal p H of the enzyme was 5.6, and the activity profile was stable in a range of acidity(p H 5.0–6.0). The enzyme was activated by Na+, Mg2+, Ca2+, K+, Fe2+ and Cu2+, however, it was inhibited by Fe3+, Ba2+, Zn2+, Mn2+ and Ag+. Km and Vmax values of the purified enzyme were 4.7 mg m L-1 and 0.57 μmol L-1 min-1(mg protein)-1, respectively. Only oligosaccharides with different sizes were released from carboxymethylcellulose(CMC) after hydrolysis with the purified CMCase. The putative gene encoding CMCase was cloned from A. pullulans 98, which contained an open reading frame of 954 bp(EU978473). The protein deduced contained the conserved domain of cellulase superfamily(glucosyl hydrolase family 5). The N-terminal amino acid sequence of the purified CMCase was M-A-P-H-A-E-P-Q-S-Q-T-T-E-Q-T-S-S-G-Q-F, which was consistent with that deduced from the cloned gene. This suggested that the purified CMCase was indeed encoded by the cloned CMCase gene in this yeast. | RONG Yanjun ZHANG Liang CHI Zhenming WANG Xianghong | 2015 | Journal of Ocean University of China2015，14，5： | 2 |
| 6 | A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy显示文摘During cancer treatment,chemotherapeutic drugs always result in severe side-effects and drug resistance.Therefore,combining cheomtherapy with other therapeutic modalities,such as photodynamic therapy(PDT)and designing an activable platform is promising for precise and efficient anticancer treatment.Herein,we report a“pro-drug-photosensitizer”agent,LMB-S-CPT,bearing a disulfide bond as the glutathione(GSH)-activatable linker.LMB-S-CPT can be selectively activated by GSH to release activated drug,camptothecin(CPT),for chemotherapy and activated photosensitizer,methylene blue(MB),for PDT.LMB-S-CPT exhibits excellent tumor-activatable performance when injected into tumor-bearing mice,as well as specific cancer therapy with negligible toxic side effects.The activatable pro-drug-photosensitizer offers a new strategy for chemo-photodynamic therapy and displays precise,selective and excellent antitumor effect. | Yanjun Yang Yifeng Zhang Ran Wang Xiang Rong Ting Liu Xiang Xia Jiangli Fan Wen Sun Xiaojun Peng | 2022 | Chinese Chemical Letters2022，33，10： | 2 |
| 7 | Stability and bi- furcation of a non-linear bearing-flexible rotor coupling dynamic system显示文摘 | Lu Yanjun Dai Rong Hei Di | 2009 | IMechE Journal of Mechanical En- gineering Science2009，223，4： | 1 |
| 8 | A method for determining the periodic solution and its stability of nonlinear bearing-rotor system based on observed states of the system显示文摘 | Lu Yanjun Liu Heng Dai Rong | 2009 | Journal of Engineering Tribology2009，223，2： | 1 |
| 9 | Stability and bifurcation of a non-linear bearing-flexible rotor coupling dynamic system显示文摘 | Lu Yanjun Dai Rong Hei Di | 2009 | Journal of Mechanical Engineering Science2009，223，4： | 1 |
| 10 | A method for determining the periodic solution and its stability of nonlinear bearing-rotor system based on observed states of the system显示文摘 | LU Yanjun LIU Heng DAr Rong | 2009 | IMechE Part J: Journal of Engineering Tribology2009，223，2： | 1 |
| 11 | Stability and bifurcation of nonlinear bearing-flexible rotor coupling dynamic system显示文摘 | LU Yanjun DAr Rong HEr Di | 2009 | IMechE Part C: Journal of Mechanical Engineering Science2009，223，4： | 1 |
| 12 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 13 | Joint utility optimization algorithm for secure hybrid spectrum sharing显示文摘As the rapid development of wireless communication networks has resulted in better user experiences,the spectrum resources occupied and energy consumption have increased considerably and resulted in great costs.To address the energy consumption and cost problems of spectrum sharing in cognitive radio networks,a hybrid spectrum sharing model combining the free spectrum of authorized users and the leased spectrum of mobile network operators is given.Based on the hybrid model,a function of throughput and costs,including energy consumption and transaction costs,is constructed,and a joint utility optimization problem is analyzed.The transactions between secondary users and primary users are performed on the consortium blockchain on which users can directly trade spectrum and the transaction information is recorded.In order to improve the joint utility,the Lagrange multiplier method is used to achieve the optimal solution for the sensing time,the number of secondary users involved in sensing,and the transmission power.The simulation results show that the joint utility optimization algorithm proposed in this paper can achieve higher joint utility under the constraints of the minimum throughput requirement and maximum transmission power. | 王翊 HUANG Rong XU Yaohua JIANG Fang BAI Na TANG Tao HU Yanjun | 2022 | High Technology Letters2022，28，4： | 0 |
| 14 | Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus显示文摘Dear editor,Swine influenza virus(SIV)is a member of the Orthomyxoviridae family,influenza A virus genus,which can cause the swine influenza—an acute and highly contagious respiratory disease in pigs(Brown,2000;Kothalawala et al.,2006).The SIV was first observed in 1918 in the United States and the progenitor of the SIV was the H1N1 influenza virus which caused the Spanish influenza pandemic of 1918(Shope,1931). | Shuaiyong Wang Manzhu Wang Lingxue Yu Juan Wang Jiecong Yan Xinli Rong Yanjun Zhou Tongling Shan Wu Tong Guoxin Li Hao Zheng Guangzhi Tong Hai Yu | 2022 | Virologica Sinica2022，37，4： | 0 |
| 15 | Programmed nanoparticle-loaded microparticles for effective antigen/adjuvant delivery显示文摘A microscale vaccine containing SiO_(2)nanoparticles loaded in CaC〇3 microparticles was constructed using the co-precipitation method.The antigen ovalbumin(OVA)was covalently conjugated with SiO_(2)nanoparticles,and these nanoparticles and CpG were co-encapsulated into CaCO_(3)microparticles,generating a vaccine with a size of approximately 5.2μm.Scanning electron microscopy(SEM),energy-dispersive X-ray(EDX),elemental mapping,and Fourier transform infrared(FTIR)analyses confirmed the successful preparation of the microscale vaccine;the vaccine had good storage stability without sustained antigen release,and negligible cytotoxicity to dendritic cells(DCs)and macrophages.Compared to SiO_(2)nanoparticles,the microscale vaccine can significantly improve antigen/adjuvant uptake.DCs internalized the entire microscale vaccine into lysosomes via macropinocytosis,and an increase in antigen endo/lysosomal escape was observed by confocal User scanning microscopy(CLSM).Specifically,DCs pulsed with the vaccine were fully mature,expressing high levels of costimulatory molecules(CD40,CD80,and CD86),MHCⅡ,and MHCⅠand secreting high levels of proinflammatory cytokines(IL-12,TNF-α,IL-1β,and IL-6).In addition,the vaccine had good in vivo biocompatibility,could protect the antigen from rapid degradation,and increased the retention time in lymph nodes.SiO_(2)nanoparticles-in-CaCO_(3)microparticles were an excellent carrier for antigen and adjuvant delivery.Hopefully,this study can provide some information on the design of microscale carriers for vaccine delivery systems. | Rong Xu Ying Dong Yajing Zhang Xiaoli Wang Chuangnian Zhang Yanjun Jiang | 2022 | Particuology2022，20，1： | 0 |
| 16 | 凋亡抑制蛋白Survivin和血管内皮生长因子高表达是喉鳞状细胞癌生存预后的独立预测因子(英文)显示文摘Objective: To study the relationship between Survivin and VEGF proteins in a subgroup of patients with squa-mous carcinoma of larynx. Methods: 108 cases of squamous carcinoma of larynx with clinical data were collected and expressions of Survivin and VEGF in peripheral blood were investigated by enzyme-linked immunosorbent assay (ELISA). Results: Expressions of Survivin and VEGF were significantly associated with T stage, N stage and metastasis of squamous carcinoma of larynx. The patients with Survivin or VEGF over-expressions presented lower survival rate, respectively, as compared to those of low-expression (P < 0.05). The survival rate in squamous carcinoma of larynx patients with Survivin and VEGF dual over-expressions was significantly lower than that of patients with dual low-expression (P < 0.05). Multivariate analysis indicated that both Survivin and VEGF over-expressions in squamous carcinoma of larynx peripheral blood samples were strong independent factors of poor prognosis in squamous carcinoma of larynx patients. Conclusion: Survivin and VEGF over-expressions are independent prognostic factors for the patients with squamous carcinoma of larynx. These results also suggest that peripheral blood Survivin and VEGF expressions are valuable prognostic markers for prognosis prediction in squamous carcinoma of larynx patients. | Rong Luo Weijia Kong Yanjun Wang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，11： | 0 |
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