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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Recurrent Pain in Children and Adolescents显示文摘 | Ana Maria B | 2003 | Jornal de Pediatria2003，79，1： | 1 |
| 3 | Phenolic compounds and antioxidant potential of commercial wines显示文摘 | Rosana CM Massimo R Luciano B | 2003 | Food Chem2003，82，： | 1 |
| 4 | Effect of salinity temperature water content and pH on the microwave demulsification of crude oil emulsions 显示文摘 | Montserrat Fortuny Cesar B Z Oliveira Rosana L F V Melo | 2007 | Energy&Fuels2007，21，： | 1 |
| 5 | Biosensors and Bioelectronics 显示文摘 | Laura G Rosana B L Marta E D | 2008 | 23(7): 1101-11082008，23，7： | 1 |
| 6 | ' Alperujo' compost amendment of contaminated calcareous and acidic soils: Effects on growth and trace element uptake by five Brossica species显示文摘 | Fernando F Rosana G-de-la-F Rosa M B | 2009 | Bioresource Technology2009，100，： | 1 |
| 7 | Effect of lyophilised vaccinium berries on memory, anxiety and locomotion in adult rats 显示文摘 | ROSANA R M IVAN I MARIA C B | 2005 | Pharmacol Res2005，52，6： | 1 |
| 8 | Mimicking molecular receptors for antibiotics-analytical implications 显示文摘 | ALFONSO F G LAURA G ROSANA B L | 2006 | Trends Anal Chem2006，25，10： | 1 |
| 9 | Phenolic compounds and total anti-oxidant potential of commercial wines显示文摘 | ROSANA C M MASSIMO R LUCIANO B | 2003 | Food Chemistry2003，83，3： | 1 |
| 10 | Antioxidant activity of Ilex paraguariensis and related species显示文摘 | Rosana Filip M S Silvina B Lotito M S | 2000 | Nutrition Research2000，20，10： | 1 |
| 11 | Effect of salinity, temperature, water content, and pH on the microwave demulsification of crude oil emulsions 显示文摘 | Montserrat Fortuny Cesar B Z Oliveira Rosana L F V Melo | 2007 | Energy & Fuels2007，21，3： | 1 |
| 12 | Antioxidant activity of Ilex paraguarensis and related species显示文摘 | Rosana Filip M S Silvina B Lotito M S | 2000 | Nutrition Research2000，20，10： | 1 |
| 13 | Development of microsatellite markers for the genetic analysis of Magnaporthe grisea显示文摘 | Claudio B Rosana P Vianello B | 2000 | Genetics and Molecular Biology2000，23，4： | 1 |
| 14 | A solgel-derived bioactive fibrous mesh 显示文摘 | Rosana Z domingues Arther E Clark Anthony B Brennan | 2001 | J Biomed Mater Res2001，55，： | 1 |
| 15 | Effect of salinity, temperature, water content, and pH on the microwave demulsification of crude oil emulsions 显示文摘 | Montserrat Fortuny Cesar B Z Oliveira Rosana L F V Melo | 2007 | Energy & Fuels2007，21，3： | 1 |
| 16 | Evaluation of water treatment sludges toxicity using the Daphnia bioassay显示文摘 | ROSANA B SOTERO SANTOS O R | 2005 | Water Research2005，39，16： | 1 |
| 17 | ^177Lu-antibody conjugates for single-cell kill of B-lymphoma cells in vitro and for therapy of micrometastases in vivo显示文摘 | Rosana B M Philip M A Adriane V R | 2005 | Nucl Med Biol2005，32，： | 1 |
| 18 | Gut microbiota-derived metabolites are novel targets for improving insulin resistance显示文摘The gut microbiota plays a key role in metabolic diseases.Gut-microbiota-derived metabolites are found in different dietary sources,including:Carbohydrate(acetate,propionate,butyrate,also known as short-chain fatty acids,as well as succinate);protein(hydrogen sulfide,indole,and phenylacetic acid);and lipids(resveratrol-,ferulic acid-,linoleic acid-,catechin-and berry-derived metabolites).Insulin resistance,which is a global pandemic metabolic disease that progresses to type 2 diabetes mellitus,can be directly targeted by these metabolites.Gutmicrobiota-derived metabolites have broad effects locally and in distinct organs,in particular skeletal muscle,adipose tissue,and liver.These metabolites can modulate glucose metabolism,including the increase in glucose uptake and lipid oxidation in skeletal muscle,and decrease in lipogenesis and gluconeogenesis associated with lipid oxidation in the liver through activation of phosphatidylinositol 3-kinase-serine/threonine-protein kinase B and AMP-activated protein kinase.In adipose tissue,gut-microbiota-derived metabolites stimulate adipogenesis and thermogenesis,inhibit lipolysis,and attenuate inflammation.Importantly,an increase in energy expenditure and fat oxidation occurs in the whole body.Therefore,the therapeutic potential of current pharmacological and non-pharmacological approaches used to treat diabetes mellitus can be tested to target specific metabolites derived from intestinal bacteria,which may ultimately ameliorate the hyperglycemic burden. | Rosana MC Bastos Érika B Rangel | 2022 | World Journal of Diabetes2022，13，1： | 1 |
| 19 | Fatty acids andcholesterol oxidation in salted and dried shrimp显示文摘 | Geni RS Deborah B Rosana S | 2006 | Food Chemistry2006，95，2： | 1 |
| 20 | Mimicking molecular receptors for antibiotics -analytical implications显示文摘 | ALFONSO F G LAURA G ROSANA B L | 2006 | Trends Anal Chem2006，25，10： | 1 |
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