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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Evaluation of the role of genes encoding for At -pyrroline~5-carboxylate syn- thetase (P5CS) during drought stress in arbuscular mycor- rhizal Glycine max and Lactuca sativa plants 显示文摘 | ROSA P ROSARIO A JUAN M R | 2004 | Physiol Mol Plant P2004，65，4： | 1 |
| 3 | RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice 显示文摘 | Song F Hurtado del Pozo C Rosario R | 2014 | Diabetes2014，63，6： | 1 |
| 4 | In vitro release of adenosine triphosphate from the urothelium of human bladders with detrusor overactivity, both neurogenic and idiopathic 显示文摘 | Kumar V Chapple C R Rosario D | 2010 | Eur Urol2010，57，6： | 1 |
| 5 | Changes in corneal aspherieity after laser in situ keratomileusis显示文摘 | Rosario GA Jose R J Luis JB | 2003 | Cataract Refract Surg2003，29，： | 1 |
| 6 | The role of lipid peroxidation in stor-age disorders of fresh fruits and vegetables显示文摘 | SHEWFELT R DEL ROSARIO B | 2000 | Hort Science2000，35，4： | 1 |
| 7 | ^177 Lu-Antibody Conjugates for Single-Cell Kill of B- Lymphoma Cells in Vitro and for Therapy of Micrometastases in Vivo 显示文摘 | Michel R B Andrews P M Rosario A V | 2005 | Nuel Med Biol2005，32，3： | 1 |
| 8 | Fullerenes as a new class of radioprotectors 显示文摘 | Lin H S Lin T S Lai R S D'Rosario T Luh T Y | 2001 | Int J Radiat Biol2001，77，： | 1 |
| 9 | Primary hypertension and nephropathy显示文摘 | Rosario R F Wesson D E | 2006 | Curr Opin Nephrel Hypertens2006，15，2： | 1 |
| 10 | A Risk Factor For Early-onset Infection in Premature Newborns:Invasion of Chorioamniotic Tissues by Leukocytes显示文摘 | Schultz R do Rosario Dias de Oliveira L | 1999 | Early Hum Dev1999，56，1： | 1 |
| 11 | Development of a method for the determination of UV filters in water samples using stir bar sorptive extraction and thermal desorption- gas chromatography- mass spectrometrty显示文摘 | ROSARIO R MONIKA M | 2008 | J Chromatogr: A2008，1179，2： | 1 |
| 12 | RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model显示文摘 | Aleshin A Ananthakrishnan R Li Q Rosario R Lu Y Qu W | 2008 | Am J Physiol Heart Circ Physiol2008，294，： | 1 |
| 13 | Investigation of Glazing Behavior in a Fire Environment Using a Spectral Discrete Ordinates Method for Radiative HeatTransfer 显示文摘 | Dembele S Rosario R A F Wen J X | 2007 | Numerical Heat Transfer Part B2007，52，： | 1 |
| 14 | Thermo-struc tural behaviour of an UHTC made nose cap of a reentry vehicle显示文摘 | Rosario B Aniello R Domenico T | | 0，，03： | 1 |
| 15 | 显示文摘 | Michelle R S Caitlin E M Rosario A G et aI | 2012 | Polymer2012，53，4： | 1 |
| 16 | Pulmonary nocardio-sis: risk factors, clinical features, diagnosis and prognosis显示文摘 | Raquel M Soledad R Rosario E | 2008 | Curr Opin Pulm Med2008，14，3： | 1 |
| 17 | Tomato root dis- tribution, yield and fruit quality under subsurface drip irrigation 显示文摘 | Machado R M Rosario M D Oliveira G | 2003 | Plant & Soil2003，255，1： | 1 |
| 18 | Androgen regulation of β-amyloid protein and the risk of Alzheimer's disease显示文摘 | Rosario E R Pike C J | 2008 | Brain Res Rev2008，57，2： | 1 |
| 19 | A model to predict the yield of determinate tomatoes显示文摘 | Santos J R A Gomez A A Rosario T L | 1992 | Scientia Horticulturae1992，50，： | 1 |
| 20 | Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling显示文摘 | Ishida-Takahashi R Rosario F Gong Y | 2006 | Molecular and Cellular Biology2006，，： | 1 |
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