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| 1 | Insulin resistance is associated with subclinical vascular disease in humans显示文摘Insulin resistance is associated with subclinical vascular disease that is not justified by conventional cardiovascular risk factors,such as smoking or hypercholesterolemia.Vascular injury associated to insulin resistance involves functional and structural damage to the arterial wall that includes impaired vasodilation in response to chemical mediators,reduced distensibility of the arterial wall(arterial stiffness),vascular calcification,and increased thickness of the arterial wall.Vascular dysfunction associated to insulin resistance is present in asymptomatic subjects and predisposes to cardiovascular diseases,such as heart failure,ischemic heart disease,stroke,and peripheral vascular disease.Structural and functional vascular disease associated to insulin resistance is highly predictive of cardiovascular morbidity and mortality.Its pathogenic mechanisms remain undefined.Prospective studies have demonstrated that animal protein consumption increases the risk of developing cardiovascular disease and predisposes to type 2 diabetes(T2D)whereas vegetable protein intake has the opposite effect.Vascular disease linked to insulin resistance begins to occur early in life.Children and adolescents with insulin resistance show an injured arterial system compared with youth free of insulin resistance,suggesting that insulin resistance plays a crucial role in the development of initial vascular damage.Prevention of the vascular dysfunction related to insulin resistance should begin early in life.Before the clinical onset of T2D,asymptomatic subjects endure a long period of time characterized by insulin resistance.Latent vascular dysfunction begins to develop during this phase,so that patients with T2D are at increased cardiovascular risk long before the diagnosis of the disease. | María M Adeva-Andany Eva Ameneiros-Rodríguez Carlos Fernández-Fernández Alberto Domínguez-Montero Raquel Funcasta-Calderón | 2019 | World Journal of Diabetes2019，10，2： | 14 |
| 2 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 3 | Determination of 23 pesticide residues in leafy vegetables using gas chromatography–ion trap mass spectrometry and analyte protectants显示文摘 | Rosa M a . González-Rodríguez Raquel Rial-Otero Beatriz Cancho-Grande Jesús Simal-Gándara | 2008 | Journal of Chromatography A2008，，： | 2 |
| 4 | Kiwifruit leaf protoplasts competent for plant regeneration and direct DNA transfer 显示文摘 | RAQUEL M HELENA OLIVEIRA M MARGARIDA | 1996 | Plant Sci (Shannon)1996，121，1： | 1 |
| 5 | A multicentre randomized trial of combined individual and telephone counselling for smoking cessation显示文摘 | Josep M. Ramon Isabel Nerin Araceli Comino Cristina Pinet Francesc Abella José M a Carreras Marta Banque Antoni Baena Sergio Morchon Adriana Jimenez-Muro Adriana Marqueta Assumpcio Vilarasau Raquel Bullon Cristina Masuet-Aumatell | 2013 | Preventive Medicine2013，，： | 1 |
| 6 | Nosema ceronae, a new microsporidian parasite in honeybees in Europe显示文摘 | Mariano H Raquel M Aranzazu M | 2006 | J Invert Pathol2006，92，2： | 1 |
| 7 | Prediction -based approaches to construct the energy map for wireless sensor networks显示文摘 | NATH M B ANTONIO A F | 2003 | ⅩⅪ SBRC2003，5，： | 1 |
| 8 | Importance of patientspecific intraoperative guides in complex maxillofacial reconstruction 显示文摘 | DENNIS R RAQUEL G M PETER B | 2013 | J Cranio Maxill Surg2013，41，5： | 1 |
| 9 | Partitioning of ethoxylated alkylphenol surfactants in microemulsion-oil-water Systems显示文摘 | Nelson M Raquel A Alain G | 1995 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1995，100，25： | 1 |
| 10 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 11 | Effect of glutamine dipeptide on hepatic regeneration in partially hepatectomized malnourished rats 显示文摘 | Rosangela P J Luis B P Raquel M M | 2003 | Nutrition2003，19，12： | 1 |
| 12 | New genus-specific primers for the PCR identification of members of the genera Pseudonocardia and Saccharopolyspora显示文摘 | RAQUEL M LGNACIO G OLGA G | 1999 | International Journal of Systematic Bacteriology1999，49，： | 1 |
| 13 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 14 | Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide显示文摘 | Mario A Sonia R Raquel M | 2006 | Toxicol Appl Pharmacol2006，212，2： | 1 |
| 15 | New genus-specific primers for the PCR identification of novel isolates of the genera Nocardiopsis and Saccharothrix显示文摘 | RAQUEL M LGNACIO G OLGA G | 2002 | International Journal of Systematic and Evolutionary Microbiology2002，52，： | 1 |
| 16 | Symptoms at the menopausal and premenopausal years:Their relationship with insulin,glucose,cortisol,FSH,prolactin,obesity and attitudes towards sexuality显示文摘 | RAQUEL H AURORA M JUAN M M | 1995 | Psychoneuroendocrinology1995，20，8： | 1 |
| 17 | Extraordinaryoptical reflection from sub-wavelength cylinder ar-rays 显示文摘 | Raquel G M Marine L Juan J S | 2006 | Opt Express2006，14，9： | 1 |
| 18 | Enhancement of AMPA currents and GluR1 membrane expression through PKA-coupled adenosine A (2A) receptors显示文摘 | Raquel B Dias Joaquim A Ribeiro Ana M Sebastnio | 2012 | Hippocampus2012，22，2： | 1 |
| 19 | Consumer preferences for wine applying best-worst scaling: a Spanish case study显示文摘 | Rodolfo Bernabéu Mónica Díaz Raquel Olivas Miguel Olmeda | 2012 | British Food Journal2012，，9： | 1 |
| 20 | A pilot study of β-interferon for treatment of patients with chronic hepatitis B who failed to respond to α-interferon显示文摘 | Raquel M Gregorio G Inmaculada F | 2002 | J Hepatology2002，37，： | 1 |
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