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| 1 | Effect of Chinese Medicine on No or Slow Reflow after Percutaneous Coronary Intervention in Myocardial Infarction Patients: A Systematic Review and Meta-Analysis显示文摘Objective:To systematic review the effect of Chinese medicine(CM)on no or slow reflow after percutaneous coronary intervention(PCI)in myocardial infarction(MI)patients.Methods:The Pub Med,EMBASE databases,Cochrane Central Register of Controlled Trials(CENTRAL),Web of Science,China National Knowledge Infrastructure(CNKI),Chinese BioMedical Literature Database(CBM),Wanfang Knowledge Service Platform(Wanfang Database)and Chinese Scientific Journal Database(VIP)were searched up to December 2017.Randomized controlled trials(RCTs)which evaluated the effect of CM therapies on no or slow reflow after PCI in MI patients were included.The primary outcome was the effect of reperfusion.Secondary outcomes were left ventricular ejection fraction,incidence of major adverse cardiovascular events and adverse effect.Results:Ten RCTs covering 814 patients were included.Two studies revealed that the incidence of no or slow reflow was less in Shenmai Injection(参麦注射液)group than in the control group measured by thrombolysis in myocardial infarction(TIMI)2(risk ratio=0.55,95%confidence interval 0.38 to 0.81,P=0.003,I^2=37%).Two studies indicated that Salvianolate Injection showed no additional benefit on no or slow reflow measured by corrected TIMI frame count compared with the conventional treatment(mean difference–4.24,95% confidence interval–13.03 to 4.54,P=0.34,I^2=86%).In addition,Tongxinluo Capsules(通心络胶囊),Danhong Injection(丹红注射液)and Xuesaitong Injection(血塞通注射液)may have the potential to reduce no or slow reflow measured during or after PCI in individual studies.Conclusions:Current evidence from RCTs are not sufficient to evaluate the effect of CM adjuvant therapies on no or slow reflow after PCI for MI patients.The included studies are limited by small sample size and unclear baseline conditions.Further rigorously designed researches and verification studies with sufficient number of patients are warranted. | ZHANG Xiao-yu SUN Yang YANG Xin-yu HU Jia-yuan ZHENG Rui CHEN Shi-qi LI Min LI Cheng-yu JIANG Yin LIU Shuo ZHAO Chen XING Yan-wei SHANG Hong-cai | 2020 | Chinese Journal of Integrative Medicine2020，26，3： | 11 |
| 2 | Phylogeography of Spiraea alpina (Rosaceae) in the Qinghai-Tibetan Plateau inferred from chloroplast DNA sequence variations显示文摘 | Fa-Qi ZHANG Qing-Bo GAO De-Jun ZHANG Yi-Zhong DUAN Yin-Hu LI Peng-Cheng FU Rui XING Khan GULZAR Shi-Long CHEN | 2012 | Journal of Systematics and Evolution2012，50，4： | 10 |
| 3 | Decolorization of Methyl Orange by a new clay-supported nanoscale zero-valent iron:Synergetic effect,efficiency optimization and mechanism显示文摘In this study, a novel nanoscale zero-valent iron(n ZVI) composite material was successfully synthesized using a low-cost natural clay, 'Hangjin 2#clay'(HJ clay) as the support and tested for the decolorization of the azo dye Methyl Orange(MO) in aqueous solution by n ZVI particles. According to the characterization and MO decolorization experiments, the sample with 5:1 HJ clay-supported n ZVI(HJ/n ZVI) mass ratio(HJ-n ZVI5) showed the best dispersion and reactivity and the highest MO decolorization efficiency. With the same equivalent Fe0 dosage, the HJ-n ZVI1 and HJ-n ZVI5 samples demonstrated a synergetic effect for the decolorization of MO: their decolorization efficiencies were much higher than that achieved by physical mixing of HJ clay and n ZVIs, or the sum of HJ clay and n ZVIs alone. The synergetic effect was primarily due to the improved dispersion and more effective utilization of the n ZVI particles on/in the composite materials. Higher decolorization efficiency of MO was obtained at larger HJ-n ZVI dosage, higher temperature and under N2 atmosphere, while the MO initial concentration and p H were negatively correlated to the efficiency. HJ clay not only works as a carrier for n ZVI nanoparticles, but also contributes to the decolorization through an 'adsorption-enhanced reduction' mechanism. The high efficiency of HJ-n ZVI for decontamination gives it great potential for use in a variety of remediation applications. | Xiaoguang Li Ying Zhao Beidou Xi Xiaoguang Meng Bin Gong Rui Li Xing Peng Hongliang Liu | 2017 | Journal of Environmental Sciences2017，29，2： | 9 |
| 4 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 5 | Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation显示文摘AIM: Ursolic acid(UA), a pentacyclic triterpenoid, is used as an anti-inflammatory and anti-cancer agent. There were few studies on the effects of UA on differentiation, and this is the first time to elucidate the potential effect and molecular mechanism of UA on inducing differentiation in the human leukemia cell line U937. METHODS: Wright-Giemsa staining, nitroblue tetrazolium reduction assay and flow cytometric analysis were utilized to demonstrate the differentiation of U937 cells induced by UA. Western blotting and immunofluorescence assay were used to investigate the possible mechanism. RESULTS: It was found that UA could induce the differentiation of U937cells and Akt-activity was significantly increased during differentiation. Additionally, LY294002, a PI3K-Akt inhibitor, could block the differentiation of U937 cells induced by UA. CONCLUSION: UA could induce the differentiation of U937 cells by activating the PI3K/Akt pathway, and it could be a potential candidate as a differentiation-inducing agent for the therapy of leukemia. | DENG Lin ZHANG Rui TANG Feng LI Chen XING Ying-Ying XI Tao | 2014 | Chinese Journal of Natural Medicines2014，12，1： | 8 |
| 6 | Effects of acute kidney injury on acute pancreatitis patients’ survival rate in intensive care unit: A retrospective study显示文摘BACKGROUND Acute kidney injury(AKI)is one of the most common acute pancreatitis(AP)-associated complications that has a significant effect on AP,but the factors affecting the AP patients’survival rate remains unclear.AIM To assess the influences of AKI on the survival rate in AP patients.METHODS A total of 139 AP patients were included in this retrospective study.Patients were divided into AKI group(n=72)and non-AKI group(n=67)according to the occurrence of AKI.Data were collected from medical records of hospitalized patients.Then,these data were compared between the two groups and further analysis was performed.RESULTS AKI is more likely to occur in male AP patients(P=0.009).AP patients in AKI group exhibited a significantly higher acute physiologic assessment and chronic health evaluation II score,higher Sequential Organ Failure Assessment score,lower Glasgow Coma Scale score,and higher demand for mechanical ventilation,infusion of vasopressors,and renal replacement therapy than AP patients in non-AKI group(P<0.01,P<0.01,P=0.01,P=0.001,P<0.01,P<0.01,respectively).Significant differences were noted in dose of norepinephrine and adrenaline,duration of mechanical ventilation,maximum and mean values of intra-peritoneal pressure(IPP),maximum and mean values of procalcitonin,maximum and mean serum levels of creatinine,minimum platelet count,and length of hospitalization.Among AP patients with AKI,the survival rate of surgical intensive care unit and in-hospital were only 23%and 21%of the corresponding rates in AP patients without AKI,respectively.The factors that influenced the AP patients’survival rate included body mass index(BMI),mean values of IPP,minimum platelet count,and hospital day,of which mean values of IPP showed the greatest impact.CONCLUSION AP patients with AKI had a lower survival rate and worse relevant clinical outcomes than AP patients without AKI,which necessitates further attention to AP patients with AKI in surgical intensive care unit. | Ni Shi Guo-Dong Sun Yuan-Yuan Ji Ying Wang Yu-Cheng Zhu Wan-Qiu Xie Na-Na Li Qiu-Yuan Han Zhi-Dong Qi Rui Huang Ming Li Zhen-Yu Yang Jun-Bo Zheng Xing Zhang Qing-Qing Dai Gui-Ying Hou Yan-Song Liu Hong-Liang Wang Yang Gao | 2021 | World Journal of Gastroenterology2021，27，38： | 8 |
| 7 | Lead?Free Halide Double Perovskite Materials: A New Superstar Toward Green and Stable Optoelectronic Applications显示文摘Lead-based halide perovskites have emerged as excellent semiconductors for a broad range of optoelectronic applications, such as photovoltaics, lighting, lasing and photon detection. However, toxicity of lead and poor stability still represent significant challenges. Fortunately, halide double perovskite materials with formula of A_2M(I)M(III)X_6 or A_2M(IV)X_6 could be potentially regarded as stable and green alternatives for optoelectronic applications, where two divalent lead ions are substituted by combining one monovalent and one trivalent ions, or one tetravalent ion. Here, the article provides an up-to-date review on the developments of halide double perovskite materials and their related optoelectronic applications including photodetectors, X-ray detectors, photocatalyst, light-emitting diodes and solar cells. The synthesized halide double perovskite materials exhibit exceptional stability, and a few possess superior optoelectronic properties. However, the number of synthesized halide double perovskites is limited, and more limited materials have been developed for optoelectronic applications to date. In addition, the band structures and carrier transport properties of the materials are still not desired, and the films still manifest low quality for photovoltaic applications. Therefore, we propose that continuing e orts are needed to develop more halide double perovskites, modulate the properties and grow high-quality films, with the aim of opening the wild practical applications. | Liang Chu Waqar Ahmad Wei Liu Jian Yang Rui Zhang Yan Sun Jianping Yang Xing'ao Li | 2019 | Nano-Micro Letters2019，11，1： | 8 |
| 8 | High-resolution crustal structure of the Yinchuan basin revealed by deep seismic reflection profiling:implications for deep processes of basin显示文摘The Yinchuan basin, located on the western margin of the Ordos block, has the characteristics of an active continental rift. A NW-striking deep seismic reflection profile across the center of Yinchuan basin precisely revealed the fine structure of the crust. The images showed that the crust in the Yinchuan basin was characterized by vertical stratifications along a detachment located at a two-way travel time(TWT) of 8.0 s.The most outstanding feature of this seismic profile was the almost flat Mohorovicˇic′ discontinuity(Moho) and a high-reflection zone in the lower crust. This sub-horizontal Moho conflicts with the general assumption of an uplifted Moho under sedimentary basins and continental rifts, and may indicate the action of different processes at depth during the evolution of sedimentary basins or rifts.We present a possible interpretation of these deep processes and the sub-horizontal Moho. The high-reflection zone, which consists of sheets of high-density, mantlederived materials, may have compensated for crustal thinning in the Yinchuan basin, leading to the formation of a sub-horizontal Moho. These high-density materials may have been emplaced by underplating with mantlesourced magma. | Xing fuHuang Shaoying Feng Rui Gao Wenhui Li | 2016 | Earthquake Science2016，29，2： | 8 |
| 9 | A new panaxadiol from the acid hydrolysate of Panax ginseng显示文摘新 panaxadiol (化合物 1 ) 从人参属人参 C. 迈耶·阿(Araliaceae ) 的全部的人参皂甙的酸 hydrolysate 被获得。根据分光镜的数据和单个水晶的 X 光检查衍射数据,它的化学结构被阐明是马树脂 --(E)-20(22)-ene-3β,12β,25-triol。 | Li Na Tao Qin Meng Jian Yuan Yin Rui Xing Hao Ran Guo | 2009 | Chinese Chemical Letters2009，20，6： | 7 |
| 10 | Convenient fabrication of BiOBr ultrathin nanosheets with rich oxygen vacancies for photocatalytic selective oxidation of secondary amines显示文摘Photocatalytic oxidation has been widely employed in organic synthesis,by virtue of the green,mild and simple reaction conditions as well as high selectivity.Introducing oxygen vacancies (OVs) with proper concentrations into the photocatalysts has been proven as an effective strategy to boost the catalytic performances.However,the currently used treatment method under high temperature at reducing atmosphere inevitably introduces a large number of OVs at the interior of the catalyst and serving as the recombination centers of carriers.To address this issue,here we develop a facile solvothermal process to prepare ultrathin BiOBr nanosheets with rich surface OVs.This method effectively decreases the bulk of the material and the ratio of interior OVs,rendering most of the OVs exposed on the surfaces which act as exposed catalytic sites and enhance the separation of carriers,therefore significantly elevates the photocatalytic performances.For the photo-oxidation reaction of secondary amines,under the conditions of visible light,ambient temperature and atmosphere,the BiOBr nanosheets featuring rich surface OVs deliver a doubled conversion compared to those with low OV concentrations,and a high selectivity of 99%,a high stability as the performance shows no reduction after 5 times of circular reaction. | Xuanjue Tong Xing Cao Tong Han Weng-Chon Cheong Rui Lin Zheng Chen Dingsheng Wang Chen Chen Qing Peng Yadong Li | 2019 | Nano Research2019，12，7： | 7 |
| 11 | Analysis of RDSS positioning accuracy based on RNSS wide area differential technique显示文摘The BeiDou Navigation Satellite System(BDS) provides Radio Navigation Service System(RNSS) as well as Radio Determination Service System(RDSS).RDSS users can obtain positioning by responding the Master Control Center(MCC) inquiries to signal transmitted via GEO satellite transponder.The positioning result can be calculated with elevation constraint by MCC.The primary error sources affecting the RDSS positioning accuracy are the RDSS signal transceiver delay,atmospheric trans-mission delay and GEO satellite position error.During GEO orbit maneuver,poor orbit forecast accuracy significantly impacts RDSS services.A real-time 3-D orbital correction method based on wide-area differential technique is raised to correct the orbital error.Results from the observation shows that the method can successfully improve positioning precision during orbital maneuver,independent from the RDSS reference station.This improvement can reach 50% in maximum.Accurate calibration of the RDSS signal transceiver delay precision and digital elevation map may have a critical role in high precise RDSS positioning services. | XING Nan SU RanRan ZHOU JianHua HU XiaoGong GONG XiuQiang LIU Li HE Feng GUO Rui REN Hui HU GuangMing ZHANG Lei | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 6 |
| 12 | Amplification of the miR-181c/d cluster is inversely correlated with PDCD4 expression in gastric cancer显示文摘miR-181c/d is dysregulated in gastric cancer(GC).We investigated the amplification and expression of miR-181c/d and its predicted target genes in GC.Amplification of miR-181c/d was quantified by genomic real-time PCR in GC and adjacent normal tissues,as well as the levels of mature miR-181c/d was performed by real-time PCR in the same tissues.The potential target genes of miR-181c/d were predicted using bioinformatics software.Expression of one potential target gene,PDCD4,was measured by semiquantitative RT-PCR,real-time PCR,and immunohistochemistry.Next,the relationship between miR181c/d expression and PDCD4 expression was analyzed.Results indicated that the amplification and expression of miR-181c/d were significantly higher in GC than in adjacent normal tissues(primary miR-181c/d,P\0.001;miR-181c,P=0.0344;miR-181d,P=0.0153),and there was a strong correlation between mature miR-181c/d and primary miR-181c/d.Thirty-two target genes were predicted,including PDCD4 which is a known tumor suppressor gene.Expression of PDCD4 was significantly down-regulated in GC as compared to adjacent normal tissues and was inversely correlated with miR-181c/d expression in GC(miR-181c and PDCD4:R=-0.496,P=0.008;miR-181d and PDCD4:R=-0.454,P=0.003).Therefore,miR-181c/d may play a pivotal role in the pathogenesis of GC by downregulating PDCD4 expression. | Yuanming Pan Rui Xing Juan An Jiantao Cui Wenmei Li Mingzhou Guo Youyong Lu | 2014 | Chinese Science Bulletin2014，59，19： | 6 |
| 13 | Quantitatively determine the dominant driving factors of the spatial–temporal changes of vegetation NPP in the Hengduan Mountain area during 2000-2015显示文摘The Hengduan mountain area,located in the upper reaches of the Yangtze River of China,is an important ecological barrier that significantly impacts the climate and ecological environment of the surrounding region and western China as a whole.This paper introduces the gravity center model used to analyze the spatial-temporal variation patterns of vegetation Net Primary Productivity(NPP)from 2000 to 2015,which were determined by the use of MOD17 A3 NPP products.Additionally,the dominant driving factors of the spatial–temporal changes of vegetation NPP of the Hengduan Mountain area were quantitatively determined with a geographical detector over 2000-2015.The results revealed that:(1)From 2000 to 2015,there was an increasing trend of vegetation NPP in the Hengduan mountain area.Throughout the whole study region,the vegetation NPP with a mean value of 611.37 gC·m^(-2)·a^(-1) indicated a decreasing trend from southeast to northwest in terms of spatial distribution.(2)The gravity centers of vegetation NPP in 2000-2015 were mainly concentrated in Zhongdian County.During the study period,the gravity center of vegetation NPP moved northward,which indicated that the increment and increasing rate of vegetation NPP in the northern parts were greater than that of the southern areas.(3)The vegetation NPP showed a moderately positive correlation with temperature,accumulated temperature(>10℃),and sunshine,while there was an overall negative relationship between NPP and precipitation.(4)The dominant factors and interactive dominant factors changed in different subregions over different segments of the study period.The dominant factors of most sub-regions in Hengduan mountain were natural factors,and the climate change factors played an increasingly greater role over the 16 years of the study period. | CHEN Shu-ting GUO Bing ZHANG Rui ZANG Wen-qian WEI Cui-xia WU Hong-wei YANG Xiao ZHEN Xiao-yan LI Xing ZHANG Da-fu HAN Bao-min ZHANG Hai-ling | 2021 | Journal of Mountain Science2021，18，2： | 5 |
| 14 | Overexpression of p42.3 promotes cell growth and tumorigenicity in hepatocellular carcinoma显示文摘AIM:To investigate the association of p42.3 expression with clinicopathological characteristics and the biological function of p42.3 in human hepatocellular carcinoma(HCC).METHODS:We used reverse transcription-polymerase chain reaction(RT-PCR),quantitative real-time RT-PCR and western blotting to detect p42.3 mRNA and protein expression in hepatic cell lines.We examined primary HCC samples and matched adjacent normal tissue by immunohistochemistry to investigate the correlation between p42.3 expression and clinicopathological features.HepG2 cells were transfected with a pIRES2EGFP-p42.3 expression vector to examine the function of the p42.3 gene.Transfected cells were analyzed for their viability and malignant transformation abilities by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,colony formation assay,and tumorigenicity assay in nude mice.RESULTS:p42.3 is differentially expressed in primary HCC tumors and cell lines.Approximately 69.6%(96/138) of cells were p42.3-positive in hepatic tumor tissues,while 30.7%(35/114) were p42.3-positive in tumor-adjacent normal tissues.Clinicopathological characteristics of the HCC specimens revealed a significant correlation between p42.3 expression and tumor differentiation(P = 0.031).However,p42.3 positivity was not related to tumor tumor-node-metastasis classification,hepatitis B virus status,or hepatoma type.Regarding p42.3 overexpression in stably transfected HepG2 cells,we discovered significant enhancement of cancer cell growth and colony formation in vitro,and significantly enhanced tumorigenicity in nude mice.Western blot analysis of cell cycle proteins revealed that enhanced p42.3 levels promote upregulation of proliferating cell nuclear antigen,cyclin B1 and mitotic arrest deficient 2.CONCLUSION:p42.3 promotes tumorigenicity and tumor growth in HCC and may be a potential target for future clinical cancer therapeutics. | Wei Sun Wei-Wei Dong Lin-Lin Mao Wen-Mei Li Jian-Tao Cui Rui Xing You-Yong Lu | 2013 | World Journal of Gastroenterology2013，19，19： | 5 |
| 15 | In Vivo Corrosion Resistance of Ca-P Coating on AZ60 Magnesium Alloy显示文摘 | Xing Xiao Haiying Yu Qingsan Zhu Guangyu Li Yang Qu Rui Gu | 2013 | Journal of Bionic Engineering2013，10，2： | 5 |
| 16 | Temperature dependent Raman and photoluminescence of vertical WS2/MoS2 monolayer heterostructures显示文摘Heterostructures from two-dimensional transition-metal dichalcogenides MX_2 have emerged as a hot topic in recent years due to their various fascinating properties. Here, we investigated the temperature dependent Raman and photoluminescence(PL) spectra in vertical stacked WS_2/MoS_2 monolayer heterostructures. Our result shows that both E_(2g)~1 and A_(1g) modes of WS_2 and MoS_2 vary linearly with temperature increasing from 300 to 642 K. The PL measurement also reveals strong temperature dependencies of the PL intensity and peak position. The activation energy of the thermal quenching of the PL emission has been found to be equal to 69.6 meV. The temperature dependence of the peak energy well follows the bandgap shrinkage of bulk semiconductor. | Zhijian Hu Yanjun Bao Ziwei Li Yongji Gong Rui Feng Yingdong Xiao Xiaochun Wu Zhaohui Zhang Xing Zhu Pulickel M. Ajayan Zheyu Fang | 2017 | Science Bulletin2017，62，1： | 5 |
| 17 | Development and Application of Network Toxicology in Safety Research of Chinese Materia Medica显示文摘Network toxicology that is an important branch of the network pharmacology emerges on the basis of network biology. It refers to study on the toxicological features of a constructed network model which is used to analyze toxic substances and their interaction and regulation in biological systems, particularly investigate the toxic effects of drugs and/or compatibility of medicines on body, and clarify the mechanism of toxicity. Network toxicology currently develops rapidly in safety prediction of Chinese materia medica(CMM). The application of network toxicology to safety and toxicology study on CMM is extremely beneficial to identify the toxic components and potential incompatibility of CMM. Since CMM is a complex system with multi-components, multi-targets, and multi-interactions, the network toxicology in safety prediction of CMM faces three great challenges, including integration studies of bioinformatics, innovation of methods, and tools and risk assessment in future development of the network toxicology in CMM research. In this paper, relevant database, approaches and tools that network toxicology utilized in the safety study of CMM were carefully reviewed. Based on the progress made, the scientific development and modernization of CMM will be greatly enhanced. | Xing Zhang Hui-rong Fan Ya-zhuo Li Xue-feng Xiao Rui Liu Jing-wen Qi Jie Wang Zong-peng Zhang Chang-xiao Liu Xiu-ping Shen | 2015 | Chinese Herbal Medicines2015，7，1： | 5 |
| 18 | MAWBP and MAWD inhibit proliferation and invasion in gastric cancer显示文摘AIM: To investigate role of putative mitogen-activated protein kinase activator with WD40 repeats (MAWD)/ MAWD binding protein (MAWBP) in gastric cancer (GC). METHODS: MAWBP and MAWD mRNA expression level was examined by real-time reverse transcriptasepolymerase chain reaction and semi-quantitative polymerase chain reaction in six GC cell lines. Western blotting was used to examine the protein expression levels. We developed GC cells that stably overexpressed MAWBP and MAWD, and downregulated expression by RNA interference assay. Proliferation and migration of these GC cells were analyzed by 3-(4,5-dimethyl2-thiazolyl)-2,5-diphenyl tetrazolium bromide (MTT), soft agar, tumorigenicity, migration and transwell assays. The effect of expression of MAWBP and MAWD on transforming growth factor (TGF)-β1-induced epithelialmesenchymal transition (EMT) was examined by transfection of MAWBP and MAWD into GC cells. We detected the levels of EMT markers E-cadherin, N-cadherin and Snail in GC cells overexpressing MAWBP and MAWD by Western blotting. The effect of MAWBP and MAWD on TGF-β signal was detected by analysis of phosphorylation level and nuclear translocation of Smad3 using Western blotting and immunofluorescence. RESULTS: Among the GC cell lines, expression of endogenous MAWBP and MAWD was lowest in SGC7901 cells and highest in BGC823 cells. MAWBP and MAWD were stably overexpressed in SGC7901 cells and knocked down in BGC823 cells. MAWBP and MAWD inhibited GC cell proliferation in vitro and in vivo . MTT assay showed that overexpression of MAWBP and MAWD suppressed growth of SGC7901 cells (P < 0.001), while knockdown of these genes promoted growth of BGC823 cells (P < 0.001). Soft agar colony formation experiments showed that overexpression of MAWBP and MAWD alone or together reduced colony formation compared with vector group in SGC7901 (86.25±8.43, 12.75±4.49, 30±6.41 vs 336.75±22.55, P < 0.001), and knocked-down MAWBP and MAWD demonstrated opposite effects (131.25±16.54, 88.75±11.12, 341.75±22.23 vs 30.25±8.07, P < 0.001). Tumorigenicity experiments revealed that overexpressed MAWBP and MAWD inhibited GC cell proliferation in vivo (P < 0.001). MAWBP and MAWD also inhibited GC cell invasion. Transwell assay showed that the number of traverse cells of MAWBP, MAWD and coexpression group were more than that in vector group (84±16.57, 98.33±9.8, 29±16.39 vs 298±11.86, P < 0.001). Coexpression of MAWBP and MAWD significantly decreased the cells traversing the matrix membrane. Conversely, knocked-down MAWBP and MAWD correspondingly promoted invasion of GC cells (100.67±14.57, 72.66±8.51, 330.67±20.55 vs 27±11.53, P < 0.001). More importantly, coexpression of MAWBP and MAWD promoted EMT. Cells that coexpressed MAWBP and MAWD displayed a pebble-like shape and tight cell-cell adhesion, while vector cells showed a classical mesenchymal phenotype. Western blotting showed that expression of E-cadherin was increased, and expression of N-cadherin and Snail was decreased when cells coexpressed MAWBP and MAWD and were treated with TGF-β1. Nuclear translocation of p-Smad3 was reduced by attenuating its phosphorylation. CONCLUSION: Coexpression of MAWBP and MAWD inhibited EMT, and EMT-aided malignant cell progression was suppressed. | Dong-Mei Li Jun Zhang Wen-Mei Li Jian-Tao Cui Yuan-Ming Pan Si-Qi Liu Rui Xing You-Yong Lu | 2013 | World Journal of Gastroenterology2013，19，18： | 5 |
| 19 | Plasma spray of biofunctional(Mg, Sr)-substituted hydroxyapatite coatings for titanium alloy implants显示文摘Plasma-sprayed hydroxyapatite (HA) coatings have been widely utilized in load-bearing titanium alloy implants. In this study, Mg, Sr co-substituted HA ((Mg,Sr)-HA) nano-scale powders have been synthesized, which are further used to prepare (Mg,Sr)-HA coatings on Ti-6A1-4V alloys in order to improve the biological functions. The average size of (Mg,Sr)-HA nano particles is ~75nm. The average bonding strength for (Mg,Sr)-HA coating and samples after heat treatment at 500℃ or 600℃ for 3h are 26.17±2.11 MPa, 36.07±4.48 MPa and 37.07 ±2.95 MPa, respectively. There is a significantly increase of bonding strength likely due to low residual stress after heated treatment.MC3T3-E1 cells show a high proliferation rate when cultured with (Mg,Sr)-HA coating extract compared to the normal culture medium, which also exhibit large extension and depositi on of extracellular matrices when adhered on the coating surfaces. Thus, these (Mg,Sr)-HA coatings show high bonding strength and improved biological functions, which offer promising future applications in the fields of orthopedics and dentistry. | Lei Cao Ihsan Ullah Na Li Shiyu Niu Rujie Sun Dandan Xia Rui Yang Xing Zhang | 2019 | Journal of Materials Science & Technology2019，35，5： | 5 |
| 20 | Recent advances in non-precious metal electrocatalysts for pH-universal hydrogen evolution reaction显示文摘Hydrogen production by water electrolysis is a compelling technology to produce fuels and chemicals powered by renewable energy.It is highly desirable to develop cost-effective and durable electrocatalysts for hydrogen evolution reaction(HER).This review has summarized recent progress in mechanism understanding of non-precious metal electrocatalysts for pH-universal HER.The general approaches have been demonstrated to overcome the activity/stability limitations of the electrocatalysts for HER in a broad pH range.The perspectives and challenges for the development of p H-universal HER electrocatalysts have also been proposed.This review sheds light on the design and fabrication of high-performance electrocatalysts for versatile HER-related energy technologies. | Shen Zhang Xing Zhang Yuan Rui Ruihu Wang Xiaoju Li | 2021 | Green Energy & Environment2021，6，4： | 4 |
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