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| 1 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 2 | Performance analysis of FFH / BPSK system with partial band noise jamming and channel estimation error in high-mobility wireless communication scenarios显示文摘In this paper,we analyze the bit error ratio(BER) of fast frequency hopping(FFH) system with binary phase shift keying(BPSK) in high-mobility wireless channels.By taking into account partial band noise jamming and channel estimation errors as Gaussian noise,both of maximal-ratio combining(MRC) and equal-gain combining(EGC) schemes are considered,and exact analytical BER expressions for MRC and EGC schemes are obtained.Especially,a closed-form BER expression for the MRC scheme is also presented in high signal-to-noise ratio region.Analytical and simulation results demonstrate that,the FFH/BPSK schemes suffer from performance degradation in the presence of channel estimation errors.The worst case jamming factor is shown to be inversely proportional to the signal to jamming ratio.With properly designed frequency hopping schemes and channel estimation schemes,the performance improvement is also observed as compared with the traditional noncoherent FFH/BFSK system. | Yishan He Yufan Cheng Gang Wu Shaoqian Li | 2014 | Chinese Science Bulletin2014，59，35： | 6 |
| 3 | Cloning and expression of heat shock protein 70 gene in the haemocytes of pearl oyster ( Pinctada fucata , Gould 1850) responding to bacterial challenge显示文摘 | Zhongliang Wang Zaohe Wu Jichang Jian Yishan Lu | 2008 | Fish and Shellfish Immunology2008，，4： | 2 |
| 4 | Research on action of surfactants in process of coating copper on graphite powder显示文摘 | Yu Quanmao Wu Yishan | 1999 | Non-metallic Mines1999，22，3： | 1 |
| 5 | Regularity in the Time-dependent Dis- tribution of the Percentage of Never-cited Papers: An Empirical Pilot Study Based on the Six Joumals显示文摘 | Zewen Hu Yishan Wu | 2014 | Journal of Infor-met- tics2014，8，2014： | 1 |
| 6 | Scopus vs WOS as scientific evaluation tools:A comparative analysis based on a testing sample search on the topic of electric vehicles显示文摘Based on a bibliometric analysis in combination with other information analysis methods,this paper compares the different evaluation results on the subject of'electric vehicles'drawn from Web of Science(WOS)and from Scopus.We came to the following conclusions after a careful comparison of these two databases.Firstly,both WOS and Scopus would provide some valid and unique evaluation indicators.Secondly,they showed similar results in terms of evaluating research performance of countries and research organizations involved in the targeted subject fields.In fact,both databases are good for discovering the research trend in general at the macroscopic level.Lastly,we ought to take the disciplinary characteristics,the extent of journal inclusion and resource selection criteria as well as inevitable data errors into full account in making recommendations to policy decision-makers. | WANG Na PAN Yuntao MA Zheng WU Yishan | 2010 | Chinese Journal of Library and Information Science2010，，1： | 1 |
| 7 | Scientific collaboration in China as reflected in co-authorship显示文摘 | Yan Wang Yishan Wu Yuntao Pan Zheng Ma Ronald Rousseau | 2005 | Scientometrics2005，，2： | 1 |
| 8 | Regularity in the time - dependent distribu- tion of the percentage of never - cited papers: An empirical pilotstudy based on the six journals 显示文摘 | Hu Zewen Wu Yishan | 2014 | Journal of Informetrics2014，8，1： | 1 |
| 9 | Shifts in the World Science Center: Space- time Characteristics and Disciplinary Analysis显示文摘 | Liang liming Feng Ye Wu Yishan | 2002 | Interdisciplinary Science Reviews2002，，3： | 1 |
| 10 | Raman and infrared spectroscopic study of kerogen treated at elevated temperatures and pressures 显示文摘 | Zeng Yishan Wu Chaodong | 2007 | Fuel2007，86，78： | 1 |
| 11 | Regularity in the time-dependentdistribution of the percentage of never-cited papers : Anempirical pilot study based on the six journals 显示文摘 | Hu Zewen Wu Yishan | 2014 | Journal of Informetrics2014，，8： | 1 |
| 12 | Raman and infrared spectroscopic study of kerogen treated at elevated temperatures and pressures 显示文摘 | Zeng Yishan Wu Chaodong | 2007 | Fuel2007，86，78： | 1 |
| 13 | A survey study on motivations for citation:A case study on periodicals research and library and information science community in China显示文摘A large number of theoretical and empirical studies on citation behavior have been conducted internationally.Although some theoretical studies on such topic have been carried out in China,few studies have focused specifically on this area from an empirical perspective,resulting in the lack of literature on the findings of actual surveys.To address this challenge,we conducted two questionnaire surveys to understand the motivations of the researchers on citation.One survey covers the authors who published articles in Chinese Journal of Scientific and Technical Periodicals,while the other targets the most productive and most cited Chinese authors in library and information science.The results show that citation behavior is not only motivated by rational factors,but also by other social factors. | MA Feng WU Yishan | 2009 | Chinese Journal of Library and Information Science2009，，3： | 1 |
| 14 | Scientific collaboration in China as reflected in co - authorship 显示文摘 | Yan Wang YiShan Wu YunTao Pan Zheng Ma Rousseau | 2005 | Scientometrics2005，62，： | 1 |
| 15 | Seamless and early gap healing of osteochondral defects by autologous mosaicplasty combined with bioactive supramolecular nanofiber-enabled gelatin methacryloyl(BSN-GelMA)hydrogel显示文摘Autologous mosaicplasty is a common approach used to treat osteochondral defects in clinical practice.Gap integration between host and transplanted plugs requires bone tissue reservation and hyaline cartilage regeneration without uneven surface,graft necrosis and sclerosis.However,poor gap integration is a serious concern,which eventually leads to deterioration of joint function.To deal with such complications,this study has developed a strategy to effectively enhance integration of the gap region following mosaicplasty by applying injectable bioactive supramolecular nanofiber-enabled gelatin methacryloyl(GelMA)hydrogel(BSN-GelMA).A rabbit osteochondral defect model demonstrated that BSN-GelMA achieved seamless osteochondral healing in the gap region between plugs of osteochondral defects following mosaicplasty,as early as six weeks.Moreover,the International Cartilage Repair Society score,histology score,glycosaminoglycan content,subchondral bone volume,and collagen II expression were observed to be the highest in the gap region of BSN-GelMA treated group.This improved outcome was due to bio-interactive materials,which acted as tissue fillers to bridge the gap,prevent cartilage degeneration,and promote graft survival and migration of bone marrow mesenchymal stem cells by releasing bioactive supramolecular nanofibers from the GelMA hydrogel.This study provides a powerful and applicable approach to improve gap integration after autologous mosaicplasty.It is also a promising off-the-shelf bioactive material for cell-free in situ tissue regeneration. | Hongwei Wu Yuna Shang Wei Sun Xinyi Ouyang Wenyan Zhou Jieji Lu Shuhui Yang Wei Wei Xudong Yao g Xiaozhao Wang Xianzhu Zhang Yishan Chen Qiulin He Zhimou Yang Hongwei Ouyang | 2023 | Bioactive Materials2023，，1： | 1 |
| 16 | An enhanced localization method for moving targets in coal mines based on witness nodes显示文摘 | HU Qingsong DING Yishan WU Lixin | 2015 | International Journal of Distributed Sensor Networks2015，，： | 1 |
| 17 | China scientific and technical papers and citations (CSTPC) : History, impact and outlook 显示文摘 | Wu Yishan Pan Yuhua Zhang Yuntao | 2004 | Scientometrics2004，60，3： | 1 |
| 18 | Selection of databases, indicators and models for evaluating research performance of Chinese universities 显示文摘 | Liang Liming Wu Yishan | 2001 | Research Evaluation2001，10，2： | 1 |
| 19 | A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration显示文摘Articular cartilage damage is a universal health problem.Despite recent progress,chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration.Loss-of-function changes are frequently observed in chondrocyte expansion and other pathological conditions,but the characteristics and intermediate molecular mechanisms remain unclear.In this study,we demonstrate a time-lapse atlas of chondrocyte dedifferentiation to provide molecular details and informative biomarkers associated with clinical chondrocyte evaluation.We performed various assays,such as single-cell RNA sequencing(scRNA-seq),live-cell metabolic assays,and assays for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq),to develop a biphasic dedifferentiation model consisting of early and late dedifferentiation stages.Early-stage chondrocytes exhibited a glycolytic phenotype with increased expression of genes involved in metabolism and antioxidation,whereas late-stage chondrocytes exhibited ultrastructural changes involving mitochondrial damage and stress-associated chromatin remodeling.Using the chemical inhibitor BTB06584,we revealed that early and late dedifferentiated chondrocytes possessed distinct recovery potentials from functional phenotype loss.Notably,this two-stage transition was also validated in human chondrocytes.An image-based approach was established for clinical use to efficiently predict chondrocyte plasticity using stage-specific biomarkers.Overall,this study lays a foundation to improve the quality of chondrocytes in clinical use and provides deep insights into chondrocyte dedifferentiation. | Yishan Chen Yeke Yu Ya Wen Juan Chen Junxin Lin Zixuan Sheng Wenyan Zhou Heng Sun Chengrui An Jiansong Chen Weiliang Wu Chong Teng Wei Wei Hongwei Ouyang | 2022 | Bone Research2022，10，3： | 1 |
| 20 | Raman and infrared spectroscopic study of kerogen treated at elevated temperatures and pressures显示文摘 | Zeng Yishan Wu Chaodong | 2007 | Fuel2007，86，78： | 1 |
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