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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 5 | Biochemical hallmarks of tyrosine hydroxylase deficiency显示文摘 | Br(a)utigam C Wevers RA Jansen RJ | | 0，，： | 1 |
| 6 | Reliability of the total lymphocyte count as a parameter of nutrition显示文摘 | Forse RA Rompre C Crosil a P | | 0，，： | 1 |
| 7 | GEM-2:A new multifrequency electro- magnetic sensor显示文摘 | Won I J Keiswetter D A Fields G RA and Sutton L C | 1996 | Journal of Environmental and Engineering Geophysics1996，1，2： | 1 |
| 8 | Cognitive impairment in chronie obstructive pulmonary disease-a neuropsychological and spect study显示文摘 | Incalzi RA Marra C Giontano A | 2003 | J Neurol2003，250，3： | 1 |
| 9 | Single injections of a DNA plasmid that contains the hu- man bel-2 gene prevent loss and atrophy of distinct neuronal popu- lations after spinal cord injury in adult rats 显示文摘 | Shibata M Murray M Tessler A Ljubetic C Connors T Saave- dra RA | 2000 | Neurorehabil Neu- ral Repair2000，14，4： | 1 |
| 10 | Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass 显示文摘 | Fu C Mielenz JR Xiao X Ge Y hamilton CY Rodriguez M Chen F Foston M Ragauskas A Bouton J Dixon RA Wang ZY | 2011 | Proc Natl Acad Sci USA2011，108，9： | 1 |
| 11 | A networked evidence theory framework for critical infrastructure modeling 显示文摘 | FOGLIEq'rA C GASPARRI A PANZIERI S | | Critical In- frastructure Protection Ⅵ IFIP Advances in Information and Communication Technology 20]20，390，： | 1 |
| 12 | Effects of angiotensin type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus显示文摘 | Malik RA Schofield IJ Izzard A Austin C Bermann G Heagerty AM | | 0，，： | 1 |
| 13 | Elevated plasma CD105 and vitreous VEGF levels in diabetic retinopathy显示文摘 | Malik RA Li C Aziz W Oslon JA Vohra A McHardv KC | 2005 | J Cell Mol Med2005，9，3： | 1 |
| 14 | The role of pneumococcal pneumonia and meningitis 显示文摘 | Hirst RA Kadioglu A O'callaghan C | 2004 | Clin Exp Immunol2004，138，2： | 1 |
| 15 | p21 (WA F1/C IP1)Inhibits Cell Cycle Progression but Not G2/M-Phase Transition Following Methylmercury Exposure显示文摘 | MENDOZA M A PONCE RA OU Y C | 2002 | Toxicol Appl Pharmacol2002，178，： | 1 |
| 16 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 17 | Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC 显示文摘 | Raj VS Mou HH Smits SL Dekkers DH Mueller MA Dijkman R Muth DA Zaki A Fouchier RA Thiel V Drosten C Rottier PJ Osterhaus AD Bosch BJ Haagmans BL | 2013 | Nature2013，495，7440： | 1 |
| 18 | H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients显示文摘 | Schlapbach L J Aebi C Hansen AG Hirt A Jensenius JC Ammann RA | 2009 | Clin Exp Im- munol2009，157，1： | 1 |
| 19 | Recent patterns and mechanisms of carbon exchange by terrestrial ecosystems显示文摘 | Schimel D S House J I Hibbard K A Bousquet P Ciais P Peylin P Braswell B H Apps M J Baker D Bondeau A Canadell J Churkina C: Cramer W Denning A S Field CB Friedlingstein P Goodale C Heimann M Houghton RA Melillo J M Moore B 3rd Murdiyarso D Noble L Pacala S W Prentice I C Raupach M R Rayner P J Scholes R J Steffen W L Wirth C | 2001 | Nature2001，414，： | 1 |
| 20 | Diffusion-weight- ed MRI of maple syrup urine disease encephalopathy 显示文摘 | C avalleri FW Zimmerman RA Bernardi A | 2002 | Neuroradiol- ogy2002，44，： | 1 |
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