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| 1 | Characteristics of gastric cancer in Asia显示文摘Gastric cancer(GC)is the fourth most common cancer in the world with more than 70%of cases occur in the developing world.More than 50%of cases occur in Eastern Asia.GC is the second leading cause of cancer death in both sexes worldwide.In Asia,GC is the third most common cancer after breast and lung and is the second most common cause of cancer death after lung cancer.Although the incidence and mortality rates are slowly declining in many countries of Asia,GC still remains a significant public health problem.The incidence and mortality varies according to the geographic area in Asia.These variations are closely related to the prevalence of GC risk factors;especially Helicobacter pylori(H.pylori)and its molecular virulent characteristics.The gradual and consistent improvements in socioeconomic conditions in Asia have lowered the H.pylori seroprevalence rates leading to a reduction in the GC incidence.However,GC remains a significant public health and an economic burden in Asia.There has been no recent systemic review of GC incidence,mortality,and H.pylori molecular epidemiology in Asia.The aim of this report is to review the GC incidence,mortality,and linkage to H.pylori in Asia. | Rubayat Rahman Akwi W Asombang Jamal A Ibdah | 2014 | World Journal of Gastroenterology2014，20，16： | 50 |
| 2 | Liver diseases in pregnancy: Diseases not unique to pregnancy显示文摘Pregnancy is a special clinical state with several normal physiological changes that influence body organs including the liver.Liver disease can cause significant morbidity and mortality in both pregnant women and their infants.Few challenges arise in reaching an accurate diagnosis in light of such physiological changes.Laboratory test results should be carefully interpreted and the knowledge of what normal changes to expect is prudent to avoid clinical misjudgment.Other challenges entail the methods of treatment and their safety for both the mother and the baby.This review summarizes liver diseases that are not unique to pregnancy.We focus on viral hepatitis and its mode of transmission,diagnosis,effect on the pregnancy,the mother,the infant,treatment,and breast-feeding.Autoimmune hepatitis,primary biliary cirrhosis,primary sclerosing cholangitis,Wilson’s disease,Budd Chiari and portal vein thrombosis in pregnancy are also discussed.Pregnancy is rare in patients with cirrhosis because of the metabolic and hormonal changes associated with cirrhosis.Variceal bleeding can happen in up to 38%of cirrhotic pregnant women.Management of portal hypertension during pregnancy is discussed.Pregnancy increases the pathogenicity leading to an increase in the rate of gallstones.We discuss some of the interventions for gallstones in pregnancy if symptoms arise.Finally,we provide an overview of some of the options in managing hepatic adenomas and hepatocellular carcinoma during pregnancy. | Ashraf A Almashhrawi Khulood T Ahmed Rubayat N Rahman Ghassan M Hammoud Jamal A Ibdah | 2013 | World Journal of Gastroenterology2013，19，43： | 17 |
| 3 | Liver diseases in pregnancy: Diseases unique to pregnancy显示文摘Pregnancy is a special clinical state with several normal physiological changes that influence body organs including the liver.Liver disease can cause significant morbidity and mortality in both pregnant women and their infants.This review summarizes liver diseases that are unique to pregnancy.We discuss clinical conditions that are seen only in pregnant women and involve the liver;from Hyperemesis Gravidarum that happens in 1out of 200 pregnancies and Intrahepatic Cholestasis of Pregnancy(0.5%-1.5%prevalence),to the more frequent condition of preeclampsia(10%prevalence)and its severe form;hemolysis,elevated liver enzymes,and a low platelet count syndrome(12%of pregnancies with preeclampsia),to the rare entity of Acute Fatty Liver of Pregnancy(incidence of 1 per 7270 to 13000deliveries).Although pathogeneses behind the development of these aliments are not fully understood,theories have been proposed.Some propose the special physiological changes that accompany pregnancy as a precipitant.Others suggest a constellation of factors including both the mother and her fetus that come together to trigger those unique conditions.Reaching a timely and accurate diagnosis of such conditions can be challenging.The timing of the condition in relation toward which trimester it starts at is a key.Accurate diagnosis can be made using specific clinical findings and blood tests.Some entities have well-defined criteria that help not only in making the diagnosis,but also in classifying the disease according to its severity.Management of these conditions range from simple medical remedies to measures such as immediate termination of the pregnancy.In specific conditions,it is prudent to have expert obstetric and medical specialists teaming up to help improve the outcomes. | Khulood T Ahmed Ashraf A Almashhrawi Rubayat N Rahman Ghassan M Hammoud Jamal A Ibdah | 2013 | World Journal of Gastroenterology2013，19，43： | 10 |
| 4 | Role of ZnO-CeO_2 Nanostructures as a Photo-catalyst and Chemi-sensor显示文摘ZnO-CeO2 nanostructures were synthesized by simple and effcient low temperature method. The structure and morphology of the ZnO-CeO2 nanostructures were characterized by X-ray powder diffraction (XRD) and field emission scanning electron microscopy (FESEM), which revealed elongated shaped CeO2 nanoparticles with diameters of 40-90 nm distributed on the surface of elongated ZnO nanostructures with diameters of 50-200 nm (edge-centre). Further the structure of the synthesized ZnO-CeO2 nanostructure was supported by Raman spectra and Fourier transform infrared spectroscopy (FTIR). UV-vis absorption spectrum was used to confirm the optical properties of the CeO2 doped ZnO nanostructures. Photo-catalytic activity of CeO2 doped ZnO nanostructure was evaluated by degradation of acridine orange and methylene blue which degraded 84.55% and 48.65% in 170 min, respectively. ZnO-CeO2 nanostructures also showed good sensitivity (0.8331 μA·cm-2·(mol/l)-1) in short response time (10 s) by applying to chemical sensing using ethanol as a target compound by I-V technique. These degradation and chemical sensing properties of ZnO-CeO2 nanostructures are of great importance for the application of ZnO-CeO2 system as a photo-catalyst and chemical sensor. | M. Faisal Sher Bahadar Khan Mohammed M. Rahman Aslam Jamal Kalsoom Akhtar M.M. Abdullah | 2011 | Journal of Materials Science & Technology2011，27，7： | 9 |
| 5 | Primary hepatocellular carcinoma and metabolic syndrome:An update显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The incidence of hepatocellular carcinoma has increased dramatically by 80% over the past two decades in the United States. Numerous basic science and clinical studies have documented a strong association between hepatocellular carcinoma and the metabolic syndrome. These studies have documented that, in most patients, non-alcoholic fatty liver disease is the hepatic manifestation of the metabolic syndrome, which may progress to hepatocellular carcinoma through the cirrhotic process. However, minority of patients with non-alcoholic fatty liver disease may progress to hepatocellular carcinoma without cirrhosis.This review summarizes the current literature of the link between hepatocellular carcinoma and metabolic syndrome with special emphasis on various components of the metabolic syndrome including risk of association with obesity, diabetes mellitus, hyperlipidemia,and hypertension. Current understanding of pathophysiology, clinical features, treatments, outcomes,and surveillance of hepatocellular carcinoma in the background of metabolic syndrome and non-alcoholic fatty liver disease is reviewed. With the current epidemic of metabolic syndrome, the number of patients with non-alcoholic fatty liver disease is increasing.Subsequently, it is expected that the incidence and prevalence of HCC will also increase. It is very important for the scientific community to shed more light on the pathogenesis of HCC with metabolic syndrome,both with and without cirrhosis. At the same time it is also important to quantify the risk of hepatocellular carcinoma associated with the metabolic syndrome in a prospective setting and develop surveillance recommendations for detection of hepatocellular carcinoma in patients with metabolic syndrome. | Rubayat Rahman Ghassan M Hammoud Ashraf A Al-mashhrawi Khulood T Ahmed Jamal A Ibdah | 2013 | World Journal of Gastrointestinal Oncology2013，5，9： | 8 |
| 6 | Gastric cancer in Africa:Current management and outcomes显示文摘Gastric cancer is the fourth most common cancer and second most common cause of cancer death worldwide.Globally,gastric cancer poses a significant public health burden-both economically and socially.In 2008,the economic burden from premature cancer deaths and disability was$895 billion and gastric cancer was the second highest cancer responsible for healthy life lost.With the expected increase in cancer deaths and non-communicable diseases,these costs are expected to rise and impact patient care.World Health Organization,estimates a 15%increase in non-communicable disease worldwide,with more than 20%increase occurring in Africa between 2010 and 2020.Mali,West Africa,is ranked 15th highest incidence of gastric cancer worldwide at a rate of 20.3/100000,yet very scarce published data evaluating etiology,prevention or management exist.It is understood that risk factors of gastric cancer are multifactorial and include infectious agents(Helicobacter pylori,Epstein-Barr virus),genetic,dietary,and environmental factors(alcohol,smoking).Interestingly,African patients with gastric cancer are younger,in their 3rd-4th decade,and present at a late stage of the disease.There is sparse data regarding gastric cancer in Africa due to lack of data collection and under-reporting,which impacts incidence and mortality rates.Currently,GLOBOCAN,an International Agency for Research on Cancer resource,is the most comprehensive available resource allowing comparison between nations.In resource limited settings,with already restricted healthcare funding,data is needed to establish programs in Africa that increase gastric cancer awareness,curtail the economic burden,and improve patient management and survival outcomes. | Akwi W Asombang Rubayat Rahman Jamal A Ibdah | 2014 | World Journal of Gastroenterology2014，20，14： | 4 |
| 7 | Liver diseases in pregnancy: Liver transplantation in pregnancy显示文摘Pregnancy in patients with advanced liver disease is uncommon as most women with decompensated cirrhosis are infertile and have high rate of anovulation.However,if gestation ensued;it is very challenging and carries high risks for both the mother and the baby such as higher rates of spontaneous abortion,prematurity,pulmonary hypertension,splenic artery aneurysm rupture,postpartum hemorrhage,and a potential for life-threatening variceal hemorrhage and hepatic decompensation.In contrary,with orthotopic liver transplantation,menstruation resumes and most women of childbearing age are able to conceive,give birth and lead a better quality of life.Women with orthotopic liver transplantation seeking pregnancy should be managed carefully by a team consultation with transplant hepatologist,maternal-fetal medicine specialist and other specialists.Pregnant liver transplant recipients need to stay on immunosuppression medication to prevent allograft rejection.Furthermore,these medications need to be monitored carefully and continued throughout pregnancy to avoid potential adverse effects to mother and baby.Thus delaying pregnancy 1 to 2 years after transplantation minimizes fetal exposure to high doses of immunosuppressants.Pregnant female liver transplant patients have a high rate of cesarean delivery likely due to the high rate of prematurity in this population.Recent reports suggest that with close monitoring and multidisciplinary team approach,most female liver transplant recipient of childbearing age will lead a successful pregnancy. | Ghassan M Hammoud Ashraf A Almashhrawi Khulood T Ahmed Rubayat Rahman Jamal A Ibdah | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 8 | In vitro callus induction and plantlet regeneration of Achyranthes aspera L.,a high value medicinal plant显示文摘Objective:To study callus induction from different explants(internode,leaf,root)and in vitro plantlets propagation from medicinally important plant Achyranthes aspera L.Methods:Sterilized explants were prepared by uning 0.1%HgCl_2 and 0.5%Bavistin and callus was obtained when cultured onto Murashige Skoog's(MS)medium by using different concentrations and combination of 2,4-D.NAA.BAP,IAA,IBA with 3%sucrose and 0.8%agar.Induced callus was immediately transferred to MS medium containing at different concentrations of phytohormones for shootlets and rootlets induction respectively.Results:Sterilization treatment of 0.1%HgCl_2.for 2-3 min and Bavistin 0.5%for 10-12 min showed the highest percentage of asepsis and survival rate.Maximum induction of callus was obtained from a combination of 2.0 mg/L 2,4-D and 0.5 mg/L NAA from leaf.Highest shootlets number(4.83±0.l7)and length(3.8±0.16)cm were observed on full strength MS medium when fortified with BAP 4.0 mg/L and KIN 0.5 mg/L.Concerted efforts of BAP 10 mg/L and NAA 0.5 mg/L on full strength MS medium showed highest leaf number(6.77±0.94).In vitro raised shoots were allowed to root on different strengths of MS medium fortified with IAA and IBA at different concentrations.Experimentally,3.0 mg/L IBA was enabled to induce maximum rootlets number(10.0±9.82)on full strength MS medium.Afterwards,regenerated shoots with well developed roots were successfully subjected to hardening process and were acclimatized.The survived plantlets showed 66.67%survival frequency without any morphological abnormality.Conclusions:The results demonstrated that different explants were good source of callus induction,morphology analysis as well as indirect plantlets regeneration. | Monokesh Kumer Sen Shamima Nasrin Shahedur Rahman Abu Hena Mostofa Jamal | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 3 |
| 9 | Fabrication of highly sensitive acetone sensor based on sonochemically prepared as-grown Ag2O nanostructures显示文摘 | RAHMAN M M JAMAL A KHAN S B | | 0，，： | 1 |
| 10 | Gene Expression Profiling and Cancer-Related Pathways in Type I Endometrial Carcinoma显示文摘 | Fatma S.A. Saghir Isa Mohamed Rose Ahmad Zailani Hatta Mohd Dali Zainab Shamsuddin A Rahman A. Jamal Norfilza Mohd Mokhtar | 2010 | International Journal of Gynecological Cancer2010，，5： | 1 |
| 11 | First report on molecular characterization of Leishmania species from cutaneous leishmaniasis patients in southern Khyber Pakhtunkhwa province of Pakistan显示文摘Objective: To report presence of Leishmania major in Khyber Pakhtunkhwa of Pakistan, where cutaneous leishmaniasis(CL) is endemic and was thought to be caused by Leishmania tropica only. Methods: Biopsy samples from 432 CL suspected patients were collected from 3 southern districts of Khyber Pakhtunkhwa during years 2011–2016. Microscopy on Giemsa stained slides were done followed by amplification of the ribosomal internal transcribed spacer 1 gene. Results: Leishmania amastigotes were detected by microscopy in 308 of 432 samples(71.3%) while 374 out of 432 samples(86.6%) were positive by ribosomal internal transcribed spacer 1 PCR. Subsequent restriction fragment length polymorphism confirmed Leishmania tropica in 351 and Leishmania major in 6 biopsy samples. Conclusions: This study is the first molecular characterization of Leishmania species in southern Khyber Pakhtunkhwa. It confirmed the previous assumptions that anthroponotic CL is the major CL form present in Khyber Pakhtunkhwa province. Furthermore, this is the first report of Leishmania major from a classical anthroponotic CL endemic focus identified in rural areas of Kohat district in southern Khyber Pakhtunkhwa. | Mubbashir Hussain Shahzad Munir Sultan Ayaz Bahar Ullah Khattak Taj Ali Khan Niaz Muhammad Muhammad Anees Hazir Rahman Muhammad Qasim Muhammad Ameen Jamal Irfan Ahmed Kashif Rahim Humaira Mazhar Noha Watanay Mohamed Kasbari | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 1 |
| 12 | Structure and properties of solid-state synthesized poly(3,4-propylenedioxythiophene)/nano-ZnO composite显示文摘Poly(3,4-propylenedioxythiophene)/nano-Zinic Oxide(PProDOT/ZnO) composites with the content of 3-7 wt%nano-ZnO were synthesized by the solid-state method with FeCl_3 as oxidant.The structure and morphology of the composites were characterized by Fourier transform infrared(FTIR)spectroscopy,ultraviolet-visible(UV-vis) absorption spectroscopy,X-ray diffraction(XRD) and transmission electron microscopy(TEM).The electrochemical performances of the composites were investigated by galvanostatic charge-discharge,cyclic voltammetry and electrochemical impedance spectroscopy(EIS).The photocatalytic activities of the composites were investigated by the degradation of methylene blue(MB) dyes in aqueous medium under UV light irradiation.The results from FTIR and UV-vis spectra showed that the PProDOT/ZnO composites were successfully synthesized by solid-state method,and nano-ZnO had great influences on the conjugation length and oxidation degree of the polymers.Furthermore,the PProDOT/5 wt%ZnO had the highest conjugation and oxidation degree among the composites.The results of XRD analysis indicated that there were some FeCl_4^- ions as doping agent in the PProDOT matrix,and the content of ZnO had no effect on diffraction pattern of PProDOT.Morphological studies revealed that the pure PProDOT and composites had similar morphological structure,and all the composites displayed an irregular sponge like morphology.The results of electrochemical tests showed that the PProDOT/5 wt%ZnO had a higher electrochemical activity with a specific capacitance value of 220 F g^(-1) than others.The results from photocatalytic activities of the composites indicated that the PProDOT/5 wt%ZnO had better photocatalytic activity than other composites. | Ahmat Ali Ruxangul Jamal Weiwei shao Adalet Rahman Yakupjan Osman Tursun Abdiryim | 2013 | Progress in Natural Science:Materials International2013，23，6： | 1 |
| 13 | Gamma - tocotrienol and hydroxyl - chavicol synergisitically inhibits growth and induces apoptosis of human glioma ceils 显示文摘 | Amirah Abdul Rahman A Rahman A Jamal Roslan Harun | 2014 | BMC Complement&Alternative Medicine2014，14，： | 1 |
| 14 | Electrochemical properties of the poly(3,4-ethylenedioxythiophene)/single-walled carbon nanotubes composite synthesized by solid-state heating method显示文摘 | Tursun Abdiryim Aminam Ubul Ruxangul Jamal Feng Xu Adalet Rahman | 2012 | Synthetic Metals (-)2012，，17： | 1 |
| 15 | Proflbus与Proflinet在测量与自动化中的整合显示文摘在自动化领域,集成依旧是大势所趋。涉及到测试与测量系统,使用者仍然在同混合数字逻辑的高复杂性进行着斗争。盛行的方案包括专用的串行协议或者不太方便的通信方法。NI公司集成平台的目标是测量与检验用途的简单连接,以便最终减少工程费用。 | Joachim Kurpat Rahman Jamal | 2007 | 现代制造2007，，27： | 0 |
| 16 | Cardiovascular Disease Prediction Among the Malaysian Cohort Participants Using Electrocardiogram显示文摘A comprehensive study was conducted to differentiate cardiovascular disease (CVD) subjects from non-CVD subjects using short recording electrocardiogram (ECG) of 244 Malaysian adults in The MalaysianCohort project. An automated peak detection algorithm to detect nine fiducialpoints of electrocardiogram (ECG) was developed. Forty-eight features wereextracted in both time and frequency domains, including statistical featuresobtained from heart rate variability and Poincare plot analysis. These includefive new features derived from spectrum counts of five different frequencyranges. Feature selection was then made based on p-value and correlationmatrix. Selected features were used as input for five classifiers of artificialneural network (ANN), k-nearest neighbors (kNN), support vector machine(SVM), discriminant analysis (DA), and decision tree (DT). Results showedthat six features related to T wave were statistically significant in distinguishingCVD and non-CVD groups. ANN had performed the best with 94.44% specificity and 86.3% accuracy, followed by kNN with 80.56% specificity, 86.49%sensitivity and 83.56% accuracy. The novelties of this study were in providingalternative solutions to detect P-onset, P-offset, T-offset as well as QRS-onsetpoints using discrete wavelet transform method. Additionally, two out of thefive newly proposed spectral features were significant in differentiating bothgroups, at frequency ranges of 1–10 Hz and 5–10 Hz. The prediction outcomeswere also comparable to previous related studies and significantly importantin using ECG to predict cardiac-related events among CVD and non-CVDsubjects in the Malaysian population. | Mohd Zubir Suboh Nazrul Anuar Nayan Noraidatulakma Abdullah Nurul Ain Mhd Yusof Mariatul Akma Hamid Azwa Shawani Kamalul Arinfin Syakila Mohd Abd Daud Mohd Arman Kamaruddin Rosmina Jaafar Rahman Jamal | 2022 | Computers, Materials & Continua2022，，4： | 0 |
| 17 | Reprogramming Mycobacterium tuberculosis CRISPR System for Gene Editing and Genomewide RNA Interference Screening显示文摘Mycobacterium tuberculosis is the causative agent of tuberculosis(TB), which is still the leading cause of mortality from a single infectious disease worldwide. The development of novel anti-TB drugs and vaccines is severely hampered by the complicated and time-consuming genetic manipulation techniques for M. tuberculosis. Here, we harnessed an endogenous type Ⅲ-A CRISPR/Cas10 system of M. tuberculosis for efficient gene editing and RNA interference(RNAi).This simple and easy method only needs to transform a single mini-CRISPR array plasmid, thus avoiding the introduction of exogenous protein and minimizing proteotoxicity. We demonstrated that M. tuberculosis genes can be efficiently and specifically knocked in/out by this system as confirmed by DNA high-throughput sequencing. This system was further applied to single-and multiple-gene RNAi. Moreover, we successfully performed genome-wide RNAi screening to identify M. tuberculosis genes regulating in vitro and intracellular growth. This system can be extensively used for exploring the functional genomics of M. tuberculosis and facilitate the development of novel anti-TB drugs and vaccines. | Khaista Rahman Muhammad Jamal Xi Chen Wei Zhou Bin Yang Yanyan Zou Weize Xu Yingying Lei Chengchao Wu Xiaojian Cao Rohit Tyagi Muhammad Ahsan Naeem Da Lin Zeshan Habib Nan Peng Zhen F.Fu Gang Cao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 0 |
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