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| 1 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 2 | Low temperature embrittlement of duplex stainless steel: Correlation between mechanical and electrochemical behavior显示文摘 | Chandraa K Rahul Singhal Kaina V | 2010 | Materials Science and Engineering A2010，527，： | 1 |
| 3 | Characterization and 3D structure prediction of chitinase induced in sugarcane during pathogenesis of Colletotrichum falcatum显示文摘 | Rahul P R Kumar V G Sathyabhama M | | 0，，： | 1 |
| 4 | Enhanced protective immune responses against Salmonella Enteritidis infection by Salmonella secreting an Escherichia coli heat-labile enterotoxin B subunit protein显示文摘 | Rahul M Nandre Chetan V Jawale John Hwa Lee | 2013 | Comparative Immunology Microbiology and Infectious Diseases2013，36，： | 1 |
| 5 | Laparoscopic inguinal hernia repair in the pediatric age group-experience with 437 children显示文摘 | Sandesh V Parelkar Sanjay Oak Rahul Gupta | 2010 | Journal of Pediatric Surgery2010，45，： | 1 |
| 6 | Multivariate analysis of relationships between material properties, process parameters and tablet tensile strength for a-lactose m0nohydrates 显示文摘 | Rahul V H Ingunn T Annette B B | 2009 | Eur J Pharm Biopharm2009，73，： | 1 |
| 7 | A Fourier-transform infrared spectroscopic analysis of organic matter degradation in a bench-scale solid substrate fermentation (composting) system 显示文摘 | Tseng D V Rahul V Sam J T | 1996 | Biotechnology and Bioengineering1996，52，6： | 1 |
| 8 | Differences in influenza virus receptors in chickens and ducks:Implications for interspecies transmission显示文摘 | Suresh V K Rahul N Gavin A W | 2009 | J Mol Genet Med2009，3，1： | 1 |
| 9 | Quantum behaved particle swarm optimization (QPSO)for multi-objective design optimization of composite structures 显示文摘 | S N Omkar Rahul Khandelwal T V S Ananth | 2009 | Expert Systems with Applications2009，36，11： | 1 |
| 10 | An efficientalgorithm for rigorous dynamic simulation of reactivedistillation columns显示文摘 | RAHUL M KUMAR M V P DWIVEDI D | 2009 | Computers and Chemical Engineering2009，33，8： | 1 |
| 11 | Poly(lactic acid) Modifications 显示文摘 | Rasal Rahul M Janorkar Amol V Hirt Douglas E | 2010 | Progress in Polymer Science2010，35，： | 1 |
| 12 | Noise Trading and Stock Market Volatility 显示文摘 | Rahul Verma Priti V | 2006 | Journal of Multinational Financial Management2006，，17： | 1 |
| 13 | Development of copper coatings on ceramic powder by electroless technique显示文摘 | Rahul Sharma Agarwala R C Agarwala V | 2006 | Appl Surf Sci2006，252，24： | 1 |
| 14 | Quantum behaved Particle Swarm Optimization (QPSO) for multi-objective design op timization of composite structures显示文摘 | Omkar S N Khandelwal Rahul Ananth T V S | 2009 | Expert Systems with Applications2009，36，11： | 1 |
| 15 | Transmission capacity of ad-hoc networks with multiple antennas using transmit stream adaptation and interference cancellation显示文摘 | RAHUL V ROBERT W H | 2012 | IEEE Transactions on Information theory2012，58，2： | 1 |
| 16 | Review of intelligent building construction: A passive solar archi- tecture approach 显示文摘 | Rahul V Ralegaonkar Rajiv Gupta | 2010 | Renewable and Sustainable Energy Reviews2010，14，： | 1 |
| 17 | Carbon-supported Pd-Fe electrocatalysts for oxygen reduction reaction (ORR) and their methanol tolerance显示文摘 | Neergat M Gunasekar V Rahul R | | 0，，： | 1 |
| 18 | The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae显示文摘 | Derrick H Lenz Kenny C Mok Brendan N Lilley Rahul V Kulkarni Ned S Wingreen Bonnie L Bassler | 2004 | Cell2004，，1： | 1 |
| 19 | Synthesis, Characterization and Luminescence of Sr3 Al2O6 Phosphor with Trivalent Rare Earth Dpan 显示文摘 | Pallavi P Rahul G Murthy K V R | 2006 | Materials Research Bulletin2006，41，： | 1 |
| 20 | Poly( lactic acid) modifications 显示文摘 | RAHUL M R AMOL V J DOUGLAS E H | 2010 | Progress in Polymer Science2010，35，： | 1 |
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