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| 1 | Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis显示文摘Inflammatory bowel diseases(IBD),including Crohn's disease and ulcerative colitis,are complex diseases that result from the chronic dysregulated immune response in the gastrointestinal tract. The exact etiology is not fully understood,but it is accepted that it occurs when an inappropriate aggressive inflammatory respon-se in a genetically susceptible host due to inciting environmental factors occurs. To investigate the path-ogenesis and etiology of human IBD,various animal models of IBD have been developed that provided indispensable insights into the histopathological and morphological changes as well as factors associated with the pathogenesis of IBD and evaluation of therapeutic options in the last few decades. The most widely used experimental model employs dextran sodium sulfate(DSS) to induce epithelial damage. The DSS colitis model in IBD research has advantages over other various chemically induced experimental models due to its rapidity,simplicity,reproducibility and controllability. In this manuscript,we review the newer publicized advances of research in murine colitis models that focus upon the disruption of the barrier function of the intestine,effects of mucin on the development of colitis,alterations found in microbial balance and resultant changes in the metabolome specifically in the DSS colitis murine model and its relation to the pathogenesis of IBD. | Derrick D Eichele Kusum K Kharbanda | 2017 | World Journal of Gastroenterology2017，23，33： | 50 |
| 2 | Effect of drainage on CO_2, CH_4, and N_2O fluxes from aquaculture ponds during winter in a subtropical estuary of China显示文摘Aquaculture ponds are dominant features of the landscape in the coastal zone of China.Generally,aquaculture ponds are drained during the non-culture period in winter.However,the effects of such drainage on the production and flux of greenhouse gases(GHGs)from aquaculture ponds are largely unknown.In the present study,field-based research was performed to compare the GHG fluxes between one drained pond(DP,with a water depth of 0.05 m)and one undrained pond(UDP,with a water depth of 1.16 m)during one winter in the Min River estuary of southeast China.Over the entire study period,the mean CO_2flux in the DP was(0.75±0.12)mmol/(m^2·hr),which was significantly higher than that in the UDP of(-0.49±0.09)mmol/(m^2·hr)(p<0.01).This indicates that drainage drastically transforms aquaculture ponds from a net sink to a net source of CO_2in winter.Mean CH_4and N_2O emissions were significantly higher in the DP compared to those in the UDP(CH_4=(0.66±0.31)vs.(0.07±0.06)mmol/(m^2·hr)and N_2O=(19.54±2.08)vs.(0.01±0.04)μmol/(m^2·hr))(p<0.01),suggesting that drainage would also significantly enhance CH_4and N_2O emissions.Changes in environmental variables(including sediment temperature,p H,salinity,redox status,and water depth)contributed significantly to the enhanced GHG emissions following pond drainage.Furthermore,analysis of the sustained-flux global warming and cooling potentials indicated that the combined global warming potentials of the GHG fluxes were significantly higher in the DP than in the UDP(p<0.01),with values of739.18 and 26.46 mg CO_2-eq/(m^2·hr),respectively.Our findings suggested that drainage of aquaculture ponds can increase the emissions of potent GHGs from the coastal zone of China to the atmosphere during winter,further aggravating the problem of global warming. | Ping Yang Derrick Y.F Lai Jia F.Huang Chuan Tong | 2018 | Journal of Environmental Sciences2018，30，3： | 12 |
| 3 | A Survey of Downlink Non-Orthogonal Multiple Access for 5G Wireless Communication Networks显示文摘Non-orthogonal multiple access(NOMA) has been recognized as a promising multiple access technique for the next generation cellular communication networks. In this paper, we first discuss a simple NOMA model with two users served by a single-carrier simultaneously to illustrate its basic principles. Then, a more general model with multicarrier serving an arbitrary number of users on each subcarrier is also discussed. An overview of existing works on performance analysis, resource allocation, and multiple-in-put multiple-output NOMA are summarized and discussed. Furthermore, we discuss the key features of NOMA and its potential research challenges. | WEI Zhiqiang YUAN Jinhong Derrick Wing Kwan Ng Maged Elkashlan DING Zhiguo | 2016 | ZTE Communications2016，14，4： | 8 |
| 4 | Changes in Soil Organic Carbon Dynamics in a Native C4 Plant-Dominated Tidal Marsh Following Spartina alterniflora Invasion显示文摘Invasion of an exotic C_4 plant Spartina alterniflora has been shown to increase soil organic carbon(SOC) concentrations in native C_3 plant-dominated coastal wetlands of China. However, little is known about the effects of S. alterniflora invasion on SOC concentrations and fractions in tidal marshes dominated by native C_4 plants. In this study, a field experiment was conducted in a tidal marsh dominated by the native C_4 plant Cyperus malaccensis in the Minjiang River estuary, China. Concentrations of SOC and liable SOC fractions, dissolved organic carbon(DOC), microbial biomass carbon(MBC), and easily oxidizable carbon(EOC),were measured in the top 50-cm soils of the C. malaccensis community, as well as those of three S. alterniflora communities with an invasion duration of 0–4 years(SA-4), 4–8 years(SA-8), and 8–12 years(SA-12), respectively. Results showed that both SOC stocks in the 50-cm soils and mean SOC concentrations in the surface soils(0–10 cm) of the C. malaccensis community increased with the duration of S. alterniflora invasion, whereas SOC concentrations in the 10–50-cm soils decreased slightly during the initial period of S. alterniflora invasion, before increasing again. The pattern of changes in labile SOC fractions(DOC, MBC, and EOC) with invasion duration was generally similar to that of SOC, while the ratios of labile SOC fractions to total SOC(DOC:SOC, MBC:SOC, and EOC:SOC) decreased significantly with the duration of S. alterniflora invasion. The findings of this study suggest that invasion of the exotic C_4 plant S. alterniflora into a marsh dominated by the native C_4 plant C. malaccensis would enhance SOC sequestration owing to the greater amount of biomass and lower proportion of labile SOC fractions present in the S. alterniflora communities. | jin baoshi lai derrick yuk fo gao dengzhou tong chuan zeng congsheng | 2017 | Pedosphere2017，27，5： | 7 |
| 5 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 6 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 7 | Spatial variations in CO2 fluxes in a subtropical coastal reservoir of Southeast China were related to urbanization and land-use types显示文摘Carbon dioxide(CO_(2))emissions from aquatic ecosystems are important components of the global carbon cycle,yet the CO_(2)emissions from coastal reservoirs,especially in developing countries where urbanization and rapid land use change occur,are still poorly understood.In this study,the spatiotemporal variations in CO_(2)concentrations and fluxes were investigated in Wenwusha Reservoir located in the southeast coast of China.Overall,the mean CO_(2)concentration and flux across the whole reservoir were 41.85±2.03μmol/L and 2.87±0.29 mmol/m2/h,respectively,and the reservoir was a consistent net CO_(2)source over the entire year.The land use types and urbanization levels in the reservoir catchment significantly affected the input of exogenous carbon towater.The mean CO_(2)fluxwasmuch higher from waters adjacent to the urban land(5.05±0.87 mmol/m2/hr)than other land use types.Sites with larger input of exogenous substance via sewage discharge and upstream runoff were often the hotspots of CO_(2)emission in the reservoir.Our results suggested that urbanization process,agricultural activities,and large input of exogenous carbon could result in large spatial heterogeneity of CO_(2)emissions and alter the CO_(2)biogeochemical cycling in coastal reservoirs.Further studies should characterize the diurnal variations,microbial mechanisms,and impact of meteorological conditions on reservoir CO_(2)emissions to expand our understanding of the carbon cycle in aquatic ecosystems. | Yifei Zhang Min Lyu Ping Yang Derrick Y.F.Lai Chuan Tong Guanghui Zhao Ling Li Yuhan Zhang Hong Yang | 2021 | Journal of Environmental Sciences2021，33，11： | 4 |
| 8 | 棉株氮营养状况评估方法的比较研究显示文摘在田间和温室条件下分别用传统的硝化测氮法与叶绿素仪(SPAD meter)和Cardy NO3-nitrate meter两种便携式氮素测定仪对棉花花铃期氮素营养状况进行了评估和跟踪。结果表明,传统的硝化测氮法测得的叶片全N和叶柄NO3--N含量和叶绿素仪(SPAD meter)及Cardy NO3-nitrate meter的读数都反应出大田生长的棉株叶片和叶柄的含氮量因施氮水平、棉桃载荷和后期施用叶面氮肥而不同。在较高施氮水平下,单株棉桃数较少(即低载荷)以及叶面施用氮肥的棉株叶片和叶柄的含氮量明显高于其它处理,且叶绿素仪(SPAD meter)和Cardy NO3-nitrate meter的读数与叶片的全N百分数和叶柄NO3--N含量存在显著的正相关,其相关系数在大田条件下平均为0.70;温室条件下平均为0.90。 | 王巧兰 吴礼树 赵竹青 赵林萍 Derrick Oosterhuis | 2005 | 植物营养与肥料学报2005，11，5： | 3 |
| 9 | Spontaneous intramural duodenal hematoma in type 2B von Willebrand disease显示文摘Intramural duodenal hematoma is a rare cause of a proximal gastrointestinal tract obstruction.Presentation of intramural duodenal hematoma most often occurs following blunt abdominal trauma in children,but spontaneous non-traumatic cases have been linked to anticoagulant therapy,pancreatitis,malignancy,vasculitis and endoscopy.We report an unusual case of spontaneous intramural duodenal hematoma presenting as an intestinal obstruction associated with acute pancreatitis in a patient with established von Willebrand disease,type 2B.The patient presented with abrupt onset of abdominal pain,nausea,and vomiting.Computed tomography imaging identified an intramural duodenal mass consistent with blood measuring 4.7 cm×8.7 cm in the second portion of the duodenum abutting on the head of the pancreas.Serum lipase was 3828 units/L.Patient was managed conservatively with bowel rest,continuous nasogastric decompression,total parenteral nutrition,recombinant factorⅧ(humateP)and transfusion.Symptoms resolved over the course of the hospitalization.This case highlights an important complication of an inherited coagulopathy. | Derrick D Eichele Meredith Ross Patrick Tang Grant F Hutchins Mark Mailliard | 2013 | World Journal of Gastroenterology2013，19，41： | 3 |
| 10 | 基于三电平子模块的倍电平复合式MMC变换器显示文摘为了降低模块化多电平变换器MMC(modular multilevel converter)的接线复杂度和通信失效故障概率,ABB提出了采用压接式IGBT串联的级联两电平CTL(cascaded two-level)变换器。由于桥臂子模块数由数百降为几十,CTL变换器输出电压电平数较少,需要在交流侧安装滤波器。为此,提出了基于三电平TL(three-level)子模块的倍电平复合式MMC变换器VLD-HMMC(voltage-level-doubler hybrid MMC)。每个桥臂有TL、半桥HB(halfbridge)子模块混合组成,且交流侧串联有一个全桥FB(full-bridge)子模块,输出电压电平数提高了1倍,从而省去了交流滤波器。各子模块具有脉冲自主触发功能且其功率开关由压接式器件串联组成,降低了桥臂子模块数,简化了控制器与主电路之间的接线复杂度,降低了通信故障的概率。单个功率开关短路故障不会影响系统正常运行,并且可避免了子模块电容的过度放电,保护电容器和功率开关,提高变换器的可靠性及故障穿越能力。所提拓扑结构实现了直流故障穿越运行,为HVDC换流站的设计提供了技术参考。 | 李瑞 王忠旭 Derrick Holliday 姚良忠 Barry W.Williams | 2015 | 电源学报2015，13，6： | 2 |
| 11 | Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome显示文摘 | Derrick KOng Shaylyn BMitchell Jacqueline SBarrett Sue JShepherd Peter MIrving Jessica RBiesiekierski StuartSmith Peter RGibson Jane GMuir | 2010 | Journal of Gastroenterology and Hepatology2010，，8： | 2 |
| 12 | Blood Pressure and Stroke: An Overview of Published Reviews显示文摘 | Carlene M.M. Lawes Derrick A. Bennett Valery L. Feigin Anthony Rodgers | 2004 | Stroke: Journal of the American Heart Association2004，，3： | 2 |
| 13 | Helicobacter pylori : Evidence-Based Review with a Focus on Immigrant Populations显示文摘 | Derrick Siao Ma Somsouk | 2014 | Journal of General Internal Medicine2014，，3： | 2 |
| 14 | Aligned PLGA/HA nanofibrous nanocomposite scaffolds for bone tissue engineering显示文摘 | Moncy V. Jose Vinoy Thomas Kalonda T. Johnson Derrick R. Dean Elijah Nyairo | 2008 | Acta Biomaterialia2008，，1： | 2 |
| 15 | Molecular evolution of Na^(+) channels in teleost fishes显示文摘Voltage-dependent sodium channels are critical for electrical excitability.Invertebrates possess a single sodium channel gene;two rounds of genome duplication early in vertebrates increased the number to four.Since the teleost-tetrapod split,independent gene duplications in each lineage have further increased the number of sodium channel genes to 10 in tetrapods and 8 in teleosts.Here we review how the occurrence of multiple sodium channel paralogs has influenced the evolutionary history of three groups of fishes:pufferfish,gymnotiform and mor-myriform electric fish.Pufferfish(tetraodontidae)produce a neurotoxin,tetrodotoxin,that binds to and blocks the pore of sodium channels.Pufferfish evolved resistance to their own toxins by amino acid substitutions in the pore of their sodium channels.These substitutions had to occur in parallel across multiple paralogs for organismal re-sistance to evolve.Gymnotiform and mormyriform fishes independently evolved electric organs to generate elec-tricity for communication and object localization.Two sodium channel genes are expressed in muscle in most fishes.In both groups of weakly electric fishes,one gene lost its expression in muscle and became compartmen-talized in the evolutionary novel electric organ,which is a muscle derivative.This gene then evolved at elevated rates,whereas the gene that is still expressed in muscle does not show elevated rates of evolution.In the electric organ-expressing gene,amino acid substitutions occur in parts of the channel involved in determining how long the channel will be open or closed.The enhanced rate of sequence evolution of this gene likely underlies the spe-cies-level variations in the electric signal. | Harold H.ZAKON Manda C.JOST Derrick J.ZWICKL Ying LU David M.HILLIS | 2009 | Integrative Zoology2009，4，1： | 2 |
| 16 | The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase production显示文摘 | Derrick SC Morris SL | 2007 | Cell Microbiol2007，9，6： | 1 |
| 17 | Isoflurane dosage for equivalentint raoperative electroencephalographic suppression in patients with and without epidural blockade显示文摘 | Morley A P Derrick J Seed P T | 2002 | Anesth Analg2002，95，： | 1 |
| 18 | A family study of panic disorder显示文摘 | Hopper JL Judd FK Derrick PL | 1987 | Genet Epidemiol1987，4，： | 1 |
| 19 | Whitematter injury correlates with hypertonia in an animal model ofcerebral palsy 显示文摘 | Drobyshevsky A Derrick M Wyrwicz AM | 2007 | J Cereb Blood Flow Metab2007，27，2： | 1 |
| 20 | Early pulmonary cytokine and chemokine responses in mice immunized with three different vaccines against Mycobacterium tuberculosis determined by PCR arrav显示文摘 | Lim J Derrick SC Kolibab K | 2009 | Clin Vaccine Immuno12009，16，1： | 1 |
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