|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Agenesis of the dorsal pancreas显示文摘During the last 100 years in medical literature,there are only 54 reports,including the report of Pasaoglu et al(World J Gastroenterol 2008;14:2915-2916),with clinical descriptions of agenesis of the dorsal pancreas in humans.Agenesis of the dorsal pancreas,a rare congenital pancreatic malformation,is associated with some other medical conditions such as hyperglycemia,abdominal pain,pancreatitis and a few other diseases.In approximately 50% of reported patients with this congenital malformation,hyperglycemia was demonstrated.Evaluation of hyperglycemia and diabetes mellitus in all patients with agenesis of the dorsal pancreas including description of fasting blood glucose,oral glucose tolerance test,glycated hemoglobin and medical treatment would be a future goal.Since autosomal dominant transmission has been suggested in single families,more family studies including imaging technologies with demonstration of the pancreatic duct system are needed for evaluation of this disease.With this letter to the editor,we aim to increase available information for the better understanding of this rare disease. | Wolfgang J Schnedl Claudia Piswanger-Soelkner Sandra J Wallner Robert Krause Rainer W Lipp | 2009 | World Journal of Gastroenterology2009，15，3： | 7 |
| 3 | 干旱胁迫下5种三叶草的生理反应(英文)显示文摘为了解三叶草属抗旱的生理机理,寻找适宜干旱地区种植的三叶草品种,比较了地三叶草(Trifoliumsubterraneum L.)、大花三叶草(rmichelianum Savi)、自:二三叶草(rrepens L.)、高加索三叶草(T.ambiguum M.Bieb.)和草莓三叶草(zfragiferum L.)在人工干旱条件下4wk的生长和生理反应.结果表明,干旱处理下大仡乏叶草、草莓三叶草和白三叶草地上部分干重严重减少,分别降低了70%、66%和64%,而高加索三叶草和地三叶草减少不到50%;高加索三叶草叶片水势降低到-2.0MPa以下,而其他4种三叶草只降低到-1.5MPa左右;高加索三叶草和争莓三叶草叶片光合速率降低25%,而地三叶草、白三叶草和大花三叶草下降35%~63%.此外,干旱条件下,5种供试三叶草叶片中游离脯氨酸含量普遍增加,其中高加索三叶草和白三叶草分别增加到2.5倍和3.1倍.研究显示高加索三叶草在多项重要生长和生理指标中表现出很强的抗旱性,因此认为其可作为干旱地区栽培自叶草的补充或替代种. | 蔺万煌 HOFMANN Rainer W STILWELL Stephen A | 2011 | 应用与环境生物学报2011，17，4： | 7 |
| 4 | Product configuration frameworks-a survey显示文摘 | DANIEL S RAINER W | 1998 | IEEE Expert1998，，78： | 1 |
| 5 | Expression of indoleamine 2, 3- dioxygenase in tumor endothelial cells correlates with Long-term survival of patients with renal cell carcinoma 显示文摘 | Rainer R Christoph W Oliver S | 2007 | Clin Cancer Res2007，13，23： | 1 |
| 6 | The influence of individual differences on skill in end-user computing 显示文摘 | HARRISON A W RAINER R K | 1992 | Journal of Management Information Systems1992，9，2： | 1 |
| 7 | Laser Guiding of Electron Beams in the Advanced Test Accelerator显示文摘 | CAPORASO G J RAINER F MARTINE W E | 1986 | Phys Rev Lett1986，57，13： | 1 |
| 8 | Comparison of 4 methods for quantifying posterior capsule opacification显示文摘 | Findl O Buehl W Menapace R Georgopoulos M Rainer G Siegl H | 2003 | JCataract Refract Surg2003，29，1： | 1 |
| 9 | Optical properties of Ag and Au nanoparticles dispersed within the pores of monolithic mesoporous silica 显示文摘 | Hofmeister H Rainer T | 2001 | Journal of Nanoparticle Research2001，3，56： | 1 |
| 10 | The influence of individual differences on skill in end-user computing 显示文摘 | Harrison A W Rainer J R | 1992 | Journal of Management Infor- mation Systems1992，9，1： | 1 |
| 11 | Localization of telomerase hTERT protein and survivin in placenta: relation to placental development and hydatidiform mole显示文摘 | Rainer Lehner Joanna Bobak Nam W Kim A.Laurie Shroyer Kenneth R Shroyer | 2001 | Obstetrics & Gynecology2001，，6： | 1 |
| 12 | How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis显示文摘 | Rainer H Straub Firdaus and apoptosis Arthritis S Dhabhar Johannes W J Bijlsma | 2005 | Arthritis Rheum2005，52，1： | 1 |
| 13 | EDTA is a better anticoagulant than heparin or citrate for delayed blood processing for plasma DNA analysis显示文摘 | Lam N Y Rainer T H Chiu R W Lo Y M | 2004 | Clin Chem2004，50，： | 1 |
| 14 | Partial coherence interferometry:a novel approach to biometry in cataract surgery显示文摘 | Drexler W Findl O Menapace R Rainer G Vass C Hitzenberger CK | 1998 | Am J Ophthalmol1998，126，4： | 1 |
| 15 | Kinetics of steam reforming of ethane on Ni/YSZ(yttria-stabilised zirconia) catalyst 显示文摘 | HUANG X W RAINER R | 2013 | Fuel2013，106，： | 1 |
| 16 | Analysis of lignin-derived phenols in standard referencematerials and ocean dissolved organic matter by gaschromatography/tandem mass spectrometry 显示文摘 | PATRICK L RAINER M W A SHUIWANG D | 2010 | MarineChemistry2010，118，： | 1 |
| 17 | Product configuration frameworks - a survey显示文摘 | DANIAL S RAINER W | 1998 | IEEE Intellgent Systems1998，12，4： | 1 |
| 18 | RAC-3 is a NF-kB coactivator显示文摘 | Santiago W Ignacio N Rainer L | 2000 | FEBS Letters2000，485，： | 1 |
| 19 | Advanced virtual corrective osteotomy显示文摘 | Andre N Katja B Rainer W | 2005 | International Congress Series2005，1281，： | 1 |
| 20 | Development of Environmental Indicator Systems: Experiences from Germany显示文摘 | Rainer W | 2000 | Environmental Management2000，6，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员