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| 1 | Evaluation of mannitol effect in patients with acute hepatic failure and acute-on-chronic liver failure using conventional MRI,diffusion tensor imaging and in-vivo proton MR spectroscopy显示文摘AIM:To evaluate the effect of an intravenous bolus of mannitol in altering brain metabolites, brain water content, brain parenchyma volume, cerebrospinal fluid (CSF) volume and clinical signs in controls and in patients with acute liver failure (ALF) and acute-on-chronic liver failure (ACLF), by comparing changes in conventional magnetic resonance imaging (MRI), in vivo proton magnetic resonance spectroscopy (PMRS) and diffusion tensor imaging (DTI) before and after its infusion.METHODS: Five patients each with ALF and ACLF in grade 3 or 4 hepatic encephalopathy and with clinical signs of raised intracranial pressure were studied along with five healthy volunteers. After baseline MRI, an intravenous bolus of 20% mannitol solution was given over 10 min in controls as well as in patients with ALF and ACLF. Repeat MRI for the same position was acquired 30 min after completing the mannitol injection. RESULTS: No statistically significant difference was observed between controls and patients with ALF and ACLF in metabolite ratios, DTI metrics and brain volume or CSF volume following 45 min of mannitol infusion. There was no change in clinical status at the end of post-mannitol imaging. CONCLUSION: The osmotic effect of mannitol did not result in significant reduction of brain water content, alteration in metabolite ratios or any change in the clinical status of these patients during or within 45 min of mannitol infusion. | Vivek A Saraswat Sona Saksena Kavindra Nath Pranav Mandal Jitesh Singh M Albert Thomas Ramkishore S Rathore Rakesh K Gupta | 2008 | World Journal of Gastroenterology2008，14，26： | 2 |
| 2 | Efficient Implementation of MPEG-4video encoder on RISC core显示文摘 | Prasad R V S Ramkishor K | 2003 | IEEE Trans on Consumer Electronics2003，49，2： | 1 |
| 3 | A Framework for Network of Vulnerability Analysis显示文摘 | Guangzhi Qu JayaPrakash Ramkishore | 2002 | CIIT2002，17，： | 1 |
| 4 | Ettlcient implementation of MPEG-4 video encoder on RISC core显示文摘 | Prasad RSV Ramkishor korada | 2003 | IEEE Transactions on Consumer Electronics2003，47，1： | 1 |
| 5 | Efficient implementation of MPEG-4 video encoder on RISC core 显示文摘 | Prasad RSV Ramkishor korads | 2003 | IEEE Transactions on Consumer Electronics2003，47，1： | 1 |
| 6 | Optimization of DNA Extraction from Low‐Yield and Degraded Samples Using the BioRobot<sup>?</sup> EZ1 and BioRobot<sup>?</sup> M48显示文摘 | RamKishore W.Reef Hardy Vince J.Anderson Nick A.Sanchez Martin R.Buoncristiani | 2006 | Journal of Forensic Sciences2006，，5： | 1 |
| 7 | Voltammetric quantification of anti-hepatitis drug Adefovir in biological matrix and pharmaceutical formulation显示文摘Electrochemical reduction behavior of Adefovir was studied using Hanging Mercury Drop Electrode (HMDE) in Britton-Robinson (BR) buffer solution.Voltammetric study showed one well-defined reduction peak in the potential range -1.2 to -1.4 V (vs. Ag/AgCl) due to reduction of C=N bond of the imidazole ring.Solid-phase extraction and protein-precipitation techniques were employed for extraction of Adefovir from human plasma.The proposed method allows quantification of Adefovir in human plasma over the concentration range 0.50-5.00 mg/mL with the detection limit 0.17 μg/mL,whereas in pharmaceutical formulation 0.25-2.25 μg/mL with the detection limit 0.08 μg/mL. | Rajeev Jain Ramkishor Sharma | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 0 |
| 8 | Cathodic adsorptive stripping voltammetry of an anti-emetic agent Granisetron in pharmaceutical formulation and biological matrix显示文摘Granisetron showed one well-defined reduction peak at Hanging Mercury Drop Electrode (HMDE) in the potential range from -1.3 to -1.5 V due to reduction of C=N bond. Solid-phase extraction technique was employed for extraction of Granisetron from spiked human plasma. Granisetron showed peak current enhancement of 4.45% at square-wave voltammetry and 5.33% at cyclic voltammetry as compared with the non stripping techniques. The proposed voltammetric method allowed quantification of Granisetron in pharmaceutical formulation over the target concentration range of 50-200 ng/mL with detection limit 13.63 ng/mL, whereas in human plasma 50-225 ng/mL with detection limit 11.75 ng/mL. | Rajeev Jain Ramkishor Sharma | 2012 | Journal of Pharmaceutical Analysis2012，2，6： | 0 |
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