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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features显示文摘AIM To investigate the association between 16 insertiondeletions(INDEL) polymorphisms, colorectal cancer(CRC) risk and clinical features in an admixed population.METHODS O n e h u n d re d a n d fo r ty p a t i e n t s w i t h C R C a n d 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on Gene Mapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology scoring.RESULTS Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis(TNM) stage risk, the Ins alleles of ACE, HLAG and TP53(6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk.CONCLUSION The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings. | Diego Marques Layse Raynara Ferreira-Costa Lorenna Larissa Ferreira-Costa Romualdo da Silva Correa Aline Maciel Pinheiro Borges Fernanda Ribeiro Ito Carlos Cesar de Oliveira Ramos Raul Hernandes Bortolin André Ducati Luchessi Andrea Ribeiro-dos-Santos Sidney Santos Vivian Nogueira Silbiger | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 3 | Interfacial and colloidal behavior of asphaltenes obtained from Brazilian crude oils 显示文摘 | Antonio Carlos Da Silva Ramos Lilian Haraguchi Fabio R Notrispe | 2001 | Journal of Petroleum Science and Engineering2001，32，： | 1 |
| 4 | Water Quality of Aroeira River for Use in Irrigation of Vegetable Crops in the Northern Region of the State of Espirito Santo, Brazil显示文摘 | Joao Victor Martins Antunes Robson Bonomo Maria da Penha Piccolo Ramos Marcelo Antonio Oliveira | 2014 | Journal of Agricultural Science and Technology(A)2014，4，10： | 1 |
| 5 | The nuclear topography of abl, bcr, PML and RARa genes : evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation显示文摘 | Neves H Ramos C da Silva M G | 1999 | Blood1999，93，： | 1 |
| 6 | Heart-lung interactions with different ventilatory settings during acute lung in- jury and hypovolaemia: an experimental study显示文摘 | da Silva Ramos F J de Oliveira E M Park M | 2011 | Br J Anaesth2011，106，3： | 1 |
| 7 | Column liquid chromatographic determination of carbadox and olaquindox in feeds显示文摘 | dos Ramos FJ da Silveira IN de Graaf G | 1991 | Journal of Chromatography A1991，558，： | 1 |
| 8 | Clinicopathologic characteristics of gastric cancer in a young patient population显示文摘 | Ramos DA Salgado NN Tortes VG | 2004 | J Gastrointest Surg2004，8，3： | 1 |
| 9 | Molecular typing of Mycobacterium bovis isolates: a review 显示文摘 | Ramos DF Tavares L da Silva PE | 2014 | Braz J Microbiol2014，45，2： | 1 |
| 10 | Effect of dexamethasone on development of in vitro –produced bovine embryos显示文摘 | Priscila P.B. Santana Carla M.F. Carvalho Nathália N. da Costa Thiago V.G. Silva Priscilla C.A. Ramos Marcela S. Cordeiro Simone S.D. Santos André S. Khayat Otávio M. Ohashi Moysés S. Miranda | 2014 | Theriogenology2014，，： | 1 |
| 11 | Concentration, stock and transport rate of heavy metals in a tropical red mangrove, Natal, Brazil 显示文摘 | RAMOS E SILVA C A DA SILVA A P DE OLIVEIRA S R | 2006 | Marine Chemistry2006，99，14： | 1 |
| 12 | OSAS in children: clinical and polysomno-graphic respiratory profile显示文摘 | RAMOS RT DA CUNHA DALTRO CH GREGORIO PB | 2006 | Braz J Otorhinolmyngol2006，72，3： | 1 |
| 13 | En- ergetic and exergetic analyses of a dual-fuel diesel en- gine 显示文摘 | Yoge Jerenimo Ramos da Costa Antonio Gilson Bar-bosade Lima Celso Rosendo Bezerra Filho | 2012 | Renewable and Sustainable Energy Reviews2012，16，7： | 1 |
| 14 | Degradation of polypropylene (PP) during multiple extrusions:Thermal analysis,mechanical properties and analysis of variance显示文摘 | Helson M da Costa Valé ria D Ramos Márcia G de Oliveira | | 0，，： | 1 |
| 15 | Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada显示文摘 | Eduardo H. S. Ramos Marcílio M. Moraes Laís L. de A. Nerys Silene C. Nascimento Gardênia C. G. Milit?o Regina C. B. Q. de Figueiredo Cláudio A. G. da Camara Teresinha Gon?alves Silva Silvia R. B. Uliana | 2014 | BioMed Research International2014，，： | 1 |
| 16 | Simulation and experimental results of multiharmonic least-square fitting algorithms applied to periodic signals显示文摘 | Ramos P M Da Silva M F Martins R C | 2006 | IEEE Transactions on Instrumentation and Measurement2006，55，2： | 1 |
| 17 | Clinicopathologic characteristics of gastric cancer in a young patient population显示文摘 | Ramos DA Salgado NN Torres VG | 2004 | J Gastrointest Surg2004，8，3： | 1 |
| 18 | Degradation of polypropylene (PP) during multiple extrusions:Thermal analysis,mechanical properties and analysis of variance显示文摘 | Helson M da Costa Valé ria D Ramos M á rcia G de Oliveira | | 0，，： | 1 |
| 19 | Modification of epoxy resin:a comparison of different types of elastomer 显示文摘 | Ramos Valeria D Helson M Da Costa Soares Vera L P | 2005 | Polymer Testing2005，24，3： | 1 |
| 20 | Analysis of thermal properties and rheological behavior of LLDPE/EPDM and LLDPE/EPDM/SRT mixtures显示文摘 | Da Costa H M Valeria D Ramos | 2008 | Polymer Testing2008，27，1： | 1 |
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