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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections显示文摘The yeast Saccharomyces boulardii CNCM I-745 is one of the probiotics recommended for the prevention of antibiotic-associated diarrhea. Studies conducted in vivo and in vitro demonstrated that in the case of infectious diseases there are two potential sites of action of Saccharomyces boulardii CNCM I-745:(1)An action on enteropathogenic microorganisms(adhesion of bacteria and their elimination or an effect on their virulence factors: Toxins, lipopolysaccharide,etc.); and(2) a direct action on the intestinal mucosa(trophic effects, effects on epithelial reconstitution, anti-secretory effects, anti-inflammatory,immunomodulators). Oral administration of Saccharomyces boulardii CNCM I-745 to healthy subjects does not alter their microbiota. However, in the case of diseases associated with the use of antibiotics or chronic diarrhea, Saccharomyces boulardii CNCM I-745 can restore the intestinal microbiota faster. The interaction of Saccharomyces boulardii CNCM I-745 with the innate immune system have been recently demonstrated thus opening up a new therapeutic potential of this yeast in the case of diseases associated with intestinal infections but also other pathologies associated with dysbiosis such as inflammatory diseases. | Dorota Czerucka Patrick Rampall | 2019 | World Journal of Gastroenterology2019，25，18： | 18 |
| 3 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 4 | Association Between Markers of Glucose Metabolism and Risk for Colorectal Adenoma显示文摘 | Sanjay Rampal Moon Hee Yang Jidong Sung Hee Jung Son Yoon-Ho Choi Jun Haeng Lee Young-Ho Kim Dong Kyung Chang Poong-Lyul Rhee Jong Chul Rhee Eliseo Guallar Juhee Cho | 2014 | Gastroenterology2014，，： | 2 |
| 5 | A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease显示文摘 | Shamsul Zain Rosmawati Mohamed Sanjiv Mahadeva Phaik Cheah Sanjay Rampal Roma Basu Zahurin Mohamed | 2012 | Human Genetics2012，，7： | 2 |
| 6 | Role of Fibrates and HMG-CoA Reductase Inhibitors in Gallstone Formation显示文摘 | Francois-Xavier Caroli-Bosc Philippe Le Gall Pascal Pugliese Benoit Delabre Corinne Caroli-Bosc Jean-Francois Demarquay Jean-Pierre Delmont Patrick Rampal J.C. Montet | 2001 | Digestive Diseases and Sciences2001，，3： | 2 |
| 7 | Descriptive epidemiology ofnasopharyngeal carcinoma in peninsular Malaysia显示文摘 | Prasad U Rampal L | 1992 | Cancer Causes Control1992，3，： | 2 |
| 8 | Needle stick and sharps injuries and factors associated among health care workers in a Malaysian hospital显示文摘 | Rampal L Zakaria R Sook WL | | 0，，： | 1 |
| 9 | The association of serum lipids with coloreetal adenomas 显示文摘 | Yang MH Rampal S Sung J | 2013 | Am J Gastroenterol2013，108，5： | 1 |
| 10 | Serial testing of Malaysian health careworkers with QuantiFERON ( R ) -TB Gold In-Tube 显示文摘 | Rafiza S Rampal KG | 2012 | Int JTuberc Lung Dis2012，16，2： | 1 |
| 11 | Experimental effects of Saccharomy- ces boulardii on diarrheal pathogens显示文摘 | Czerucka D Rampal P | 2002 | Microbes Infect2002，4，7： | 1 |
| 12 | Experimental effects of Saccharomyces boulardii on diarrheal pathogens 显示文摘 | Czerucka D Rampal P | 2002 | Microbes Infect2002，4，7： | 1 |
| 13 | DAMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms 显示文摘 | Abdel-Wahab O Pardanani A Rampal R | 2011 | Leukemi- a2011，25，7： | 1 |
| 14 | Experimental effects of Saccharomyces boulardii on diarrheal pathogens显示文摘 | Czerucka D Rampal P | 2002 | Microbes Infect2002，4，7： | 1 |
| 15 | The lead content of cur- rently available new residential paint in several Asian countries 显示文摘 | Clark CS Rampal KG Thuppil V | 2006 | Environ Res2006，102，1： | 1 |
| 16 | Age structure in neutral theory resolves inconsistencies related to reproductive-size threshold显示文摘Aims Neutral theory consists of a suite of models that assume ecological equivalence among individual organisms.They have been most commonly applied to tropical forest tree communities either as null models or as approximations.Neutral models typically only include reproductive adults;therefore,fitting to empirical tree community data requires defining a reproductive-size threshold,which for trees is usually set arbitrarily to a diameter at breast height(DBH)of 100 mm.The inevitable exclusion of some reproductive adults and inclusion of some saplings cause a non-random sampling bias in neutral model fits.Here,we investigate this problem and resolve it by introducing simple age structure into a neutral model.Methods We compared the performance and sensitivity of DBH threshold of three variants of a spatially explicit neutral model:the traditional model,a model incorporating random sampling and a model with two distinct age classes—reproductive adults and saplings.In the age-structured model,saplings are offspring from adults that disperse according to a Gaussian dispersal kernel around the adults.The only extra parameter is the ratio of adults to saplings,which is not a free parameter but directly measurable.We used species–area relationships(SARs)to explore the predicted effect of saplings on the species richness at different scales in our model.We then evaluated the three model variations to find the parameters required to maintain the observed level of species richness in the 50-ha plot on Barro Colorado Island(BCI).We repeated our analysis filtering the data at different minimum tree-size thresholds in order to find the effect this threshold has on our results.Lastly,we used empirical species–individual relationships(SIRs)to test the pre-existing hypothesis that environmental filtering is the primary cause of differences between the assemblage of saplings and that of adults on BCI.Important Findings Our age-structured neutral model was characterized by SARs that were insensitive to the presence of saplings at large scales and highly sensitive to them at small scales.Both models without age structure were highly sensitive to the DBH threshold chosen in a way that could not be explained based on random samplings alone.The age-structured neutral model,which allowed for non-random sampling based on life stage,was consistent with species richness observations.Our analysis of empirical SIRs did not support environmental filtering as a dominant force,but it did show evidence for other differences between age classes.Age can now be easily incorporated into future studies of neutral models whenever there is a concern that a sample is not entirely composed of reproductive adult individuals.More generally,we suggest that modeling studies using tree data subject to a minimum size threshold should consider the sensitivity of their results to that threshold. | James Rosindell Patrick A.Jansen Rampal S.Etienne | 2012 | Journal of Plant Ecology2012，5，1： | 1 |
| 17 | The putative role of inflammation in the irritable bowel syndrome显示文摘 | Collins S M Piche T Rampal P | 2001 | Gut2001，49，： | 1 |
| 18 | Review arti- cle:yeast as probiotics-Sacchanaromyces boutardii显示文摘 | CZERUCKA D PICHE T RAMPAL P | 2007 | Aliment Pharmacol Ther2007，26，： | 1 |
| 19 | Review article:yeast as probiotics-saccharomyces boulardii显示文摘 | Czerucka D Piche T Rampal P | | 0，，06： | 1 |
| 20 | Genetic association of SNPs in the FTO gene and predisposition to obesity in Malaysian Malays 显示文摘 | Apalasanay YD Ming MF Rampal S | 2012 | Braz J Med Biol Res2012，45，12： | 1 |
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