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| 1 | Ganoderic acid hinders renal fibrosis via suppressing the TGF- β/Smad and MAPK signaling pathways显示文摘Renal fibrosis is considered as the pathway of almost all kinds of chronic kidney diseases(CKD)to the end stage of renal diseases(ESRD).Ganoderic acid(GA)is a group of lanostane triterpenes isolated from Ganoderma lucidum,which has shown a variety of pharmacological activities.In this study we investigated whether GA exerted antirenal fibrosis effect in a unilateral ureteral obstruction(UUO)mouse model.After UUO surgery,the mice were treated with GA(3.125,12.5,and 50 mg·kg^−1·d^−1,ip)for 7 or 14 days.Then the mice were sacrificed for collecting blood and kidneys.We showed that GA treatment dose-dependently attenuated UUO-induced tubular injury and renal fibrosis;GA(50 mg·kg^−1·d^−1)significantly ameliorated renal disfunction during fibrosis progression.We further revealed that GA treatment inhibited the extracellular matrix(ECM)deposition in the kidney by suppressing the expression of fibronectin,mainly through hindering the over activation of TGF-β/Smad signaling.On the other hand,GA treatment significantly decreased the expression of mesenchymal cell markers alpha-smooth muscle actin(α-SMA)and vimentin,and upregulated E-cadherin expression in the kidney,suggesting the suppression of tubular epithelial-mesenchymal transition(EMT)partially via inhibiting both TGF-β/Smad and MAPK(ERK,JNK,p38)signaling pathways.The inhibitory effects of GA on TGF-β/Smad and MAPK signaling pathways were confirmed in TGF-β1-stimulated HK-2 cell model.GA-A,a GA monomer,was identified as a potent inhibitor on renal fibrosis in vitro.These data demonstrate that GA or GA-A might be developed as a potential therapeutic agent in the treatment of renal fibrosis. | Xiao-qiang Geng Ang Ma Jin-zhao He Liang Wang Ying-li Jia Guang-ying Shao Min Li Hong Zhou Shu-qian Lin Jian-hua Ran Bao-xue Yang | 2020 | Acta Pharmacologica Sinica2020，41，5： | 43 |
| 2 | Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor显示文摘Chemotherapy-related fatigue(CRF)is increasingly being recognized as one of the severe symptoms in patients undergoing chemotherapy,which not only largely reduces the quality of life in patients,but also diminishes their physical and social function.At present,there is no effective drug for preventing and treating CRF.Ganoderic acid(GA),isolated from traditional Chinese medicine Ganoderma lucidum,has shown a variety of pharmacological activities such as anti-tumor,anti-inflammation,immunoregulation,etc.In this study,we investigated whether GA possessed anti-fatigue activity against CRF.CT26 tumor-bearing mice were treated with 5-fluorouracil(5-FU,30 mg/kg)and GA(50 mg/kg)alone or in combination for 18 days.Peripheral and central fatigue-related behaviors,energy metabolism and inflammatory factors were assessed.We demonstrated that co-administration of GA ameliorated 5-FU-induced peripheral muscle fatigue-like behavior via improving muscle quality and mitochondria function,increasing glycogen content and ATP production,reducing lactic acid content and LDH activity,and inhibiting p-AMPK,IL-6 and TNF-αexpression in skeletal muscle.Co-administration of GA also retarded the 5-FU-induced central fatigue-like behavior accompanied by down-regulating the expression of IL-6,iNOS and COX2 in the hippocampus through inhibiting TLR4/Myd88/NF-κB pathway.These results suggest that GA could attenuate 5-FU-induced peripheral and central fatigue in tumor-bearing mice,which provides evidence for GA as a potential drug for treatment of CRF in clinic. | Abudumijiti Abulizi Ling Hu Ang Ma Fang-yu Shao Hui-ze Zhu Si-mei Lin Guang-ying Shao Yue Xu Jian-hua Ran Jing Li Hong Zhou Dong-mei Lin Lian-fu Wang Min Li Bao-xue Yang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 5 |
| 3 | Eddy covariance measurements of water vapor and energy flux over a lake in the Badain Jaran Desert,China显示文摘Exploring the surface energy exchange between atmosphere and water bodies is essential to gain a quantitative understanding of regional climate change, especially for the lakes in the desert. In this study, measurements of energy flux and water vapor were performed over a lake in the Badain Jaran Desert, China from March 2012 to March 2013. The studied lake had about a 2-month frozen period(December and January) and a 10-month open-water period(February–November). Latent heat flux(LE) and sensible heat flux(Hs) acquired using the eddy covariance technique were argued by measurements of longwave and shortwave radiation. Both fluxes of longwave and shortwave radiation showed seasonal dynamics and daily fluctuations during the study period. The reflected solar radiation was much higher in winter than in other seasons. LE exhibited diurnal and seasonal variations. On a daily scale, LE was low in the morning and peaked in the afternoon. From spring(April) to winter(January), the diurnal amplitude of LE decreased slowly. LE was the dominant heat flux throughout the year and consumed most of the energy from the lake. Generally speaking, LE was mostly affected by changes in the ambient wind speed, while Hs was primarily affected by the product of water-air temperature difference and wind speed. The diurnal LE and Hs were negatively correlated in the open-water period. The variations in Hs and LE over the lake were differed from those on the nearby land surface. The mean evaporation rate on the lake was about 4.0 mm/d over the entire year, and the cumulative annual evaporation rate was 1445 mm/a. The cumulative annual evaporation was 10 times larger than the cumulative annual precipitation. Furthermore, the average evaporation rates over the frozen period and open-water period were approximately 0.6 and 5.0 mm/d, respectively. These results can be used to analyze the water balance and quantify the source of lake water in the Badain Jaran Desert. | SUN Jie HU Wenfeng WANG Nai'ang ZHAO Liqiang AN Ran NING Kai ZHANG Xunhe | 2018 | Journal of Arid Land2018，10，4： | 3 |
| 4 | Real-time GNSS precise point positioning with smartphones for vehicle navigation显示文摘The availability of raw Global Navigation Satellite System(GNSS)measurements from Android smart devices gives new possibilities for precise positioning solutions,e.g.,Precise Point Positioning(PPP).However,the accuracy of the PPP with smart devices currently is a few meters due to the poor quality of the raw GNSS measurements in a kinematic scenario and in urban environments,particularly when the smart devices are placed inside vehicles.To promote the application of GNSS PPP for land vehicle navigation with smart devices,this contribution studies the real-time PPP with smartphones.For data quality analysis and positioning performance validation,two vehicle-based kinematic positioning tests were carried out using two Huawei Mate30 smartphones and two Huawei P40 smartphones with different installation modes:the vehicle-roof mode with smartphones mounted on the top roof outside the vehicle,and the dashboard mode with smartphones stabilized on the dashboard inside the vehicle.To realize high accuracy positioning,we proposed a real-time smartphone PPP method with the data processing strategies adapted for smart devices.Positioning results show that the real-time PPP can achieve the horizontal positioning accuracy of about 1–1.5 m in terms of root-mean-square and better than 2.5 m at the 95th percentile for the vehicle-based kinematic positioning with the experimental smartphones mounted on the dashboard inside the vehicle,which is the real scenario in vehicle navigation. | Zishen Li Liang Wang Ningbo Wang Ran Li Ang Liu | 2022 | Satellite Navigation2022，3，3： | 2 |
| 5 | Germanium isotope effect induced guest rattling and cage distortion in clathrates显示文摘Intermetallic clathrates are materials characterized by a large cage structure where guest atoms can move anharmonically,providing these materials exotic thermoelectric properties.Unfortunately,the dynamical and atomic nature of the rattling phonons,and their interactions with the electronic structure,are not fully understood.Here,we report that a germanium isotope effect can trigger an inherent guest rattling and cage distortion in clathrate Ba8Ga16Ge30(BGG).Raman-scattering spectroscopy and advanced electron microscopy demonstrate that the atomic germanium isotope effect induces an offcentre rattling at the 6d sites as well as a tetrakaidecahedron deformation which is anisotropic for ntype BGG but isotropic for p-type BGG.The present findings indicate that the large n-type germanium isotope effect arises from the strong electron-phonon coupling,which opens up a novel avenue for manipulating dynamical motions of phonons via atomic isotope engineering. | Ran Ang Zhengshang Wang Shang-Fei Wu Pierre Richard Zhenzhong Yang Lin Gu Gang Mu Jingtao Xu Ning Liu Jun Tang | 2018 | Journal of Materiomics2018，4，4： | 1 |
| 6 | The Research of CDEGS in Defect Diagnosis for Grounding Grid显示文摘 | Ang Ren Qing Quan Li Ran Liu | 2014 | Applied Mechanics and Materials2014，492，： | 1 |
| 7 | Annealing engineering induced high thermoelectric performance in Yb-filled CoSb_(3) skutterudites显示文摘The great pressure of energy shortage has made CoSb_(3) materials with excellent mechanical stability in the mid-temperature region favored for the integration of thermoelectric devices.However,their ex-cessive lattice thermal conductivity and poor Seebeck coefficient lead to low energy conversion effi-ciency.Filling Yb into the lattice void to optimize the band structure and regulate the chemical po-tential is an indispensable means for improving the thermoelectric properties of CoSb_(3)-based materials,while the phase structure and thermoelectric properties vary with the preparation process.This motivates the current work to focus on the influence of annealing temperature on the microstructure and thermoelectric properties of Yb-filled CoSb_(3).Experimental analysis and theoretical model eluci-dated that an increase in annealing temperature can optimize the Yb filling fraction,which simulta-neously manipulates the band structure as well as chemical potential,resulting in an excellent electrical property.Furthermore,the phase and microstructure characterization clarify that the annealing temperature can effectively affect the grain size.The complex grain boundary induced by grain refinement,more filled Yb atoms and precipitates strongly scatter wide-frequency phonons,significantly suppressing the lattice thermal conductivity.As a result,a superior dimensionless figure of merit(ZT)value of~1.33 at 823 K and an average ZTave of~0.9(323-823 K)were achieved in the Ybo.4Co4Sb12 sample annealed at 923 K,and the calculated conversion efficiency could reach~13%.This work pro-vides a unique paradigm to improve thermoelectrics in the filled CoSb_(3)-based skutterudites by annealing engineering. | Haoran Feng Qian Deng Yan Zhong Xuri Rao Yadong Wang Jianglong Zhu Fujie Zhang Ran Ang | 2023 | Journal of Materials Science & Technology2023，，19： | 0 |
| 8 | Boosting thermoelectrics by alloying Cu_(2)Se in SnTe-CdTe compounds显示文摘The discovery of band convergence has opened an effective avenue for significantly enhancing thermoelectric performance of SnTe,while alloying CdTe in SnTe is evidenced efficient for improving the valley degeneracy.However,the thermoelectric transport properties are limited due to the low solubility of CdTe in SnTe(~3%).Inspired by the improvement of dimensionless figure of merit zT in Cu or Se-doped SnTe,investigating the effect of Cu_(2)Se on the electronic and phonon transport properties of SnTe-CdTe alloys is highly desired.Traditionally,improving the quality factor can trigger an increase of the potential of a compound for higher zT,which is of importance for design of thermoelectric materials.Here,alloyed 3%Cu_(2)Se in SnTe-3%CdTe system enables an increased peak zT,which is attributed by the optimization of electronic performance(~21μW cm^(-1)K^(-2)at 800 K),as well as the decreased lattice thermal conductivity owing to the enhanced mass and strain fluctuations.More importantly,alloying Cu_(2)Se not only improves the quality factor from~0.25 to~0.45,resulting in a higher maximum potential zT,but also effectively preserves the Fermi energy in a relative optimized level.The current findings demonstrate the role of Cu_(2)Se for manipulating thermoelectrics in SnTe. | Zhiyu Chen Juan Li Jing Tang Fujie Zhang Yan Zhong Hangtian Liu Ran Ang | 2021 | Journal of Materials Science & Technology2021，，30： | 0 |
| 9 | δ-Calculus:A New Approach to Quantifying Location Privacy显示文摘With the rapid development of mobile wireless Internet and high-precision localization devices,location-based services(LBS)bring more convenience for people over recent years.In LBS,if the original location data are directly provided,serious privacy problems raise.As a response to these problems,a large number of location-privacy protection mechanisms(LPPMs)(including formal LPPMs,FLPPMs,etc.)and their evaluation metrics have been proposed to prevent personal location information from being leakage and quantify privacy leakage.However,existing schemes independently consider FLPPMs and evaluation metrics,without synergizing them into a unifying framework.In this paper,a unified model is proposed to synergize FLPPMs and evaluation metrics.In detail,the probabilistic process calculus(calledδ-calculus)is proposed to characterize obfuscation schemes(which is a LPPM)and integrateα-entropy toδ-calculus to evaluate its privacy leakage.Further,we use two calculus moving and probabilistic choice to model nodes’mobility and compute its probability distribution of nodes’locations,and a renaming function to model privacy leakage.By formally defining the attacker’s ability and extending relative entropy,an evaluation algorithm is proposed to quantify the leakage of location privacy.Finally,a series of examples are designed to demonstrate the efficiency of our proposed approach. | Lihua Yin Ran Li Jingquan Ding Xiao Li Yunchuan Guo Huibing Zhang Ang Li | 2020 | Computers, Materials & Continua2020，，6： | 0 |
| 10 | 1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia显示文摘Autosomal dominant polycystic kidney disease(ADPKD)is the most common inherited kidney disease.Cyst development in ADPKD involves abnormal epithelial cell proliferation,which is affected by the primary cilia-mediated signal transduction in the epithelial cells.Thus,primary cilium has been considered as a therapeutic target for ADPKD.Since ADPKD exhibits many pathological features similar to solid tumors,we investigated whether targeting primary cilia using anti-tumor agents could alleviate the development of ADPKD.Twenty-four natural compounds with anti-tumor activity were screened in MDCK cyst model,and 1-Indanone displayed notable inhibition on renal cyst growth without cytotoxicity.This compound also inhibited cyst development in embryonic kidney cyst model.In neonatal kidney-specific Pkd1 knockout mice,1-Indanone remarkably slowed down kidney enlargement and cyst expansion.Furthermore,we demonstrated that 1-Indanone inhibited the abnormal elongation of cystic epithelial cilia by promoting tubulin polymerization and significantly down-regulating expression of anterograde transport motor protein KIF3A and IFT88.Moreover,we found that 1-Indanone significantly down-regulated ciliary coordinated Wnt/β-catenin,Hedgehog signaling pathways.These results demonstrate that 1-Indanone inhibits cystic cell proliferation by reducing abnormally prolonged cilia length in cystic epithelial cells,suggesting that 1-Indanone may hold therapeutic potential to retard cyst development in ADPKD. | Xiao-wei Li Jian-hua Ran Hong Zhou Jin-zhao He Zhi-wei Qiu Shu-yuan Wang Meng-na Wu Shuai Zhu Yong-pan An Ang Ma Min Li Ya-zhu Quan Nan-nan Li Chao-qun Ren Bao-xue Yang | 2023 | Acta Pharmacologica Sinica2023，44，2： | 0 |
| 11 | SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy显示文摘Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus.Interleukin-18,an inflammasomeinduced cytokine,has emerged as a novel mediator of cardiopulmonary pathologies but its regulation via SARS-CoV-2 signaling remains unknown.Based on a screening panel,IL-18 was identified amongst 19 cytokines to stratify mortality and hospitalization burden in patients hospitalized with COVID-19.Supporting clinical data,administration of SARS-CoV-2 Spike 1(S1)glycoprotein or receptor-binding domain(RBD)proteins into human angiotensin-converting enzyme 2(hACE2)transgenic mice induced cardiac fibrosis and dysfunction associated with higher NF-κB phosphorylation(pNF-κB)and cardiopulmonary-derived IL-18 and NLRP3 expression.IL-18 inhibition via IL-18BP resulted in decreased cardiac pNF-κB and improved cardiac fibrosis and dysfunction in S1-or RBD-exposed hACE2 mice.Through in vivo and in vitro work,both S1 and RBD proteins induced NLRP3 inflammasome and IL-18 expression by inhibiting mitophagy and increasing mitochondrial reactive oxygenation species.Enhancing mitophagy prevented Spike protein-mediated IL-18 expression.Moreover,IL-18 inhibition reduced Spike protein-mediated pNF-κB and EC permeability.Overall,the link between reduced mitophagy and inflammasome activation represents a novel mechanism during COVID-19 pathogenesis and suggests IL-18 and mitophagy as potential therapeutic targets. | Shuxin Liang Changlei Bao Zi Yang Shiyun Liu Yanan Sun Weitao Cao Ting Wang Tae-Hwi Schwantes-An John S.Choy Samisubbu Naidu Ang Luo Wenguang Yin Stephen M.Black Jian Wang Pixin Ran Ankit A.Desai Haiyang Tang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 12 | We Chinese People显示文摘This series takes inspiration from the true stories of'The Most Beautiful Fighters'as its creative foundation.The books capture children's love of'listening to stories'and invite many cutting-edge children's literature writers and illustrators.Through different genres and creative methods,it uses the language,perspective,and depth of understanding of children to transform the socialist core values into the core keywords of growth and cleverly integrate them into the stories. | Zheng Ange Ran Shaodan | 2024 | China Book International2024，，1： | 0 |
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