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| 1 | Kinematic analysis and experiment of planetary five-bar planting mechanism for zero-speed transplanting on mulch film显示文摘A novel seedling transplanting mechanism with planetary five-bar was developed in order to solve some problems when transplanting seedlings on mulch film,such as a large cave diameter,a low proportion of upright seedlings,and inconsistent planting depths,which seriously restrict the development of transplanting equipment used in dryland agriculture.The planetary five-bar structure of transplanting mechanism was designed based on analysis of the seedling transplanter on mulch film.The kinematics model of the transplanting mechanism was established and the optimal parameters of the transplanting mechanism were obtained by satisfying the motion trajectory conditions.Subsequently,the virtual prototype of transplanting mechanism was developed,and the simulation of motion trajectory was illustrated.Finally,the physical prototype of the transplanting mechanism was assembled and tested with the high-speed photography.The simulation results indicated that the desired“spindle”trajectory for the duckbill can be obtained,of which the height was 350 mm,and the diameter of the planting cave was 32 mm.The experimental results showed that the diameter of the planting cave was less than 70 mm,the seedling perpendicularity qualification rate reached 96%,the film injury rate was less than 0.5%,and the hanging membrane phenomenon was avoided.Therefore,the proposed transplanting mechanism can meet the requirements for a mulch-film transplanting machine. | Liu Jiaodi Cao Weibin Tian Dongyang Tang Haiyang Zhao Hongzheng | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 20 |
| 2 | Research on the strategy of angles-only relative navigation for autonomous rendezvous显示文摘This paper considers the problem of angles-only relative navigation for autonomous rendezvous. Methods for determining degree of observability (DOO) and latent range information of orbital maneuver are proposed for analyzing and enhancing the precision of relative position and velocity estimation. The equations of angles-only relative navigation are set forth on the condition that optical camera is the only viable sensor for relative measurement, and expressions for the DOO of relative navigation are obtained by using the Newton iterative method. The latent range information of orbital maneuver is analyzed, which is employed to enhance the DOO of angles-only relative navigation. Simulation result shows that DOO is effective to describe the observability level of relative position and velocity, and the latent range information is useful in enhancing the DOO of the angles-only relative navigation. | LI JiuRen LI HaiYang TANG GuoJin LUO YaZhong | 2011 | Science China(Technological Sciences)2011，54，7： | 13 |
| 3 | A pair of light signaling factors FHY3 and FAR1 regulates plant immunity by modulating chlorophyll biosynthesis显示文摘Light and chloroplast function is known to affect the plant immune response; however, the underlying mechanism remains elusive. We previously demonstrated that two light signaling factors, FAR-RED ELONGATED HYPOCOTYL 3(FHY3)and FAR-RED IMPAIRED RESPONSE 1(FAR1), regulate chlorophyll biosynthesis and seedling growth via controlling HEMB1 expression in Arabidopsis thaliana. In this study, we reveal that FHY3 and FAR1 are involved in modulating plant immunity. We showed that the fhy3 far1 double null mutant displayed high levels of reactive oxygen species and salicylic acid(SA) and increased resistance to Pseudomonas syringae pathogen infection. Microarray analysis revealed that a large proportion of pathogen-related genes, particularly genes encoding nucleotide-binding and leucine-rich repeat domain resistant proteins, are highly induced in fhy3 far1. Genetic studies indicated that the defects of fhy3 far1 can be largely rescued by reducing SA signaling or blocking SA accumulation, and by overexpression of HEMB1, which encodes a 5-aminolevulinic acid dehydratase in the chlorophyll biosynthetic pathway.Furthermore, we found that transgenic plants with reduced expression of HEMB1 exhibit a phenotype similar to fhy3 far1.Taken together, this study demonstrates an important role of FHY3 and FAR1 in regulating plant immunity, through integrating chlorophyll biosynthesis and the SA signaling pathway. | Wanqing Wang Weijiang Tang Tingting Ma De Niu Jing Bo Jin Haiyang Wang Rongcheng Lin | 2016 | Journal of Integrative Plant Biology2016，58，1： | 8 |
| 4 | Confined van der Waals Epitaxial Growth of Two-Dimensional Large Single-Crystal In_(2)Se_(3) for Flexible Broadband Photodetectors显示文摘The controllable growth of two-dimensional(2D)semiconductors with large domain sizes and high quality is much needed in order to reduce the detrimental efect of grain boundaries on device performance but has proven to be challenging.Here,we analyze the precursor concentration on the substrate surface which signifcantly infuences nucleation density in a vapor deposition growth process and design a confned micro-reactor to grow 2D In_(2)Se_(3) with large domain sizes and high quality.Te uniqueness of this confned micro-reactor is that its size is∼102-103 times smaller than that of a conventional reactor.Such a remarkably small reactor causes a very low precursor concentration on the substrate surface,which reduces nucleation density and leads to the growth of 2D In_(2)Se_(3) grains with sizes larger than 200�m.Our experimental results show large domain sizes of the 2D In_(2)Se_(3) with high crystallinity.Te fexible broadband photodetectors based on the as-grown In_(2)Se_(3) show rise and decay times of 140 ms and 25 ms,efcient response(5.6 A/W),excellent detectivity(7×10^(10) Jones),high external quantum efciency(251%),good fexibility,and high stability.Tis study,in principle,provides an efective strategy for the controllable growth of high quality 2D materials with few grain boundaries. | Lei Tang Changjiu Teng Yuting Luo Usman Khan Haiyang Pan Zhengyang Cai Yue Zhao Bilu Liu Hui-Ming Cheng | 2019 | Research2019，，1： | 7 |
| 5 | Optimal multi-objective trajectory design based on close-looped control for autonomous rendezvous显示文摘This paper considers the problem of optimal multi-objective trajectory design for autonomous rendezvous.Total velocity cost and relative state robustness of close-looped control are selected as the objective functions.Based on relative dynamics equations,the state equations and measurement equations for angles-only relative navigation between spacecrafts are set forth.According to the method of linear covariance analysis,the close-looped control covariance of the true relative state from the reference relative state is analyzed,and the objective functions of relative state robustness are formulated.Considering the total velocity cost and the relative state robustness,the multi-objective optimization algorithm of NSGA-II is employed to solve this multi-impulsive rendezvous problem.Lastly,the validity of the objective functions and the covariance results are demonstrated through 100 times Monte Carlo simulation. | LI JiuRen LI HaiYang TANG GuoJin | 2011 | Science China(Technological Sciences)2011，54，11： | 6 |
| 6 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 7 | Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus显示文摘Borna disease virus 1(BoDV-1)is neurotropic prototype of Bornaviruses causing neurological diseases and maintaining persistent infection in brain cells of mammalian species.Long non-coding RNA(lncRNA)is transcript of more than 200 nucleotides without proteincoding function regulating various biological processes as proliferation,apoptosis,cell migration and viral infection.However,regulatory of lncRNAs in BoDV-1 infection remains unknown.To identify differential expression profiles and predict functions of lncRNA in BoDV-1 infection,microarray data showed that 3528 lncRNAs and 2661 lncRNAs were differentially expressed in Strain V and Hu-H1 BoDV-infected groups compared with control groups,respectively.Gene Ontology(GO)and pathway analysis suggested that differential lncRNAs may be involved in regulation of metabolic,biological regulation,cellular process,endocytosis,viral infections and cell adhesion processes,cancer in both BoDV-infected strains.ENSMUST00000128469 was found down-regulated in both BoDV-infected groups compared with control groups consistent with microarray(p<0.05).ceRNA analysis indicated possible interaction networks as ENSMUST00000128469/miR-22-5p,miR-206-3p,miR-302b-5p,miR-302c-3p,miR-1a-3p/Igf1.Igf1 was found up-regulated in both BoDV-infected groups compared with control groups(p<0.05).Possible functions of predicted target mRNAs and miRNAs of ENSMUST00000128469 were involved in cell proliferation,transcriptional misregulation and proteoglycan pathways enriched in cancer.lncRNA may be involved in regulation of Hu-H1 inhibited cell proliferation and promoted apoptosis through NF-kB,JNK/MAPK signaling,BCL2 and CDK6/E2F1 pathways different from Strain V.Possible interaction networks as ENSMUST00000128469/miR-22-5p,miR-206-3p,miR-302b-5p,miR-302c-3p,miR-1a-3p/Igf1 may involve in regulation of cell proliferation,apoptosis,and cancer. | Lin Sun Yujie Guo Peng He Xiaoyan Xu Xiong Zhang Haiyang Wang Tian Tang Wei Zhou Ping Xu Peng Xie | 2019 | Genes & Diseases2019，6，2： | 5 |
| 8 | Human control model in teleoperation rendezvous显示文摘This paper proposes a human control model in teleoperation rendezvous on the basis of human information processing(perception, judgment, inference, decision and response). A predictive display model is introduced to provide the human operator with predictive information of relative motion. By use of this information, the longitudinal and lateral control models for the operator are presented based on phase plane control method and fuzzy control method, and human handling qualities are analyzed. The integration of these two models represents the human control model. Such a model can be used to simulate the control process of the human operator, which teleoperates the rendezvous with the aid of predictive display. Experiments with human in the loop are carried out based on the semi-Physical simulation system to verify this human control model. The results show that this human control model can emulate human operators' performance effectively,and provides an excellent way for the analysis, evaluation and design of the teleoperation rendezvous system. | ZHANG Bo LI HaiYang TANG GuoJin | 2014 | Science China(Information Sciences)2014，57，11： | 3 |
| 9 | Deformation analysis of transversely isotropic coal-rock mass with porous and cracks显示文摘Coal-rock as a typical sedimentary rock has obvious stratification,namely it has transversely isotropic feature.Meanwhile,deformation leads to coal-rock mass having the characteristics of different porous and crack structures as well as local anisotropy.Equivalent axial and circumferential strain' formulas of the pure coal-rock mass specimen with a single crack were derived through the establishment of equivalent mechanical model of standard cylindrical coal-rock specimen,and have been widely used to a variety of media combined different structures containing multiple cracks.The complete stress strain curve of a real coal-rock specimen was obtained by the CTC test.Additionally,according to the comparison with the theoretical value,the theoretical mechanical model could well explain the deformation characteristics of coal-rock mass and verify its validity.Further,following features were analyzed:strain normalized coefficient and elastic modulus(Poisson's ratio) in vertical and parallel direction to the stratification,stratification angle,porosity,pore radius,normal and tangential stiffness of crack,and the relationship of different crack width with different tangential stiffness of crack.Through the analysis above,it substantiate this claim that the theoretical model with better reliability reflects the transversely isotropic nature of the coal-rock and the local anisotropy caused by the porous and cracks. | Xue Dongjie Zhou Hongwei Kong Lin Tang Xianli Zhao Tian Yi Haiyang Zhao Yufeng | 2012 | International Journal of Mining Science and Technology2012，22，6： | 3 |
| 10 | Recent progress in gold nanoparticle-based biosensing and cellular imaging显示文摘Gold nanoparticles(Au NPs) have been extensively used in optical biosensing and bioimaging due to the unique optical properties. Biological applications including biosensing and cellular imaging based on optical properties of Au NPs will be reviewed in the paper. The content will focus on detection principles, advantages and challenges of these approaches as well as recent advances in this field. | Haiyang Peng Hao Tang Jianhui Jiang | 2016 | Science China Chemistry2016，59，7： | 3 |
| 11 | Mantle anisotropy across the southwestern boundary of the Ordos block,North China显示文摘Located at the northeastern margin of the Tibetan plateau,the Ordos block is a stable tectonic unit in North China.With its active boundary fault zones,the Ordos block played an important role in the eastward extrusion mechanism of the Tibetan plateau.Peking University deployed a linear array of 15 portable broadband seismometers across the western Weihe graben during September 2005 to August 2006 and later a 2-D seismic array(Southwest Ordos Array) of 14 portable broadband seismometers during 2007-2008 at its southwestern boundary.Analyses of shear wave splitting of SKS and SKKS phases at these stations show that the fast directions trend ~110° with an average delay time of 0.9 s in the southwestern margin of the Ordos block.The agreement between the lithosphere deformation indicated by GPS data and Quaternary fault slip-rate observations and the mantle flow represented by shear wave splitting implies that accordant deformation patterns from lithosphere to asthenosphere in relation to the eastward extrusion of the Tibetan plateau could extend at least to 200 km depth.Spatial distribution of splitting polarization directions indicates that the mantle flow driven by the Tibetan plateau is blocked by the Ordos block and locally restricted in a narrow channel along the Qinling-Dabie fault zones between the Ordos block and Sichuan basin. | Yongcai Tang Yongshun John Chen Yuanyuan V. Fu Haiyang Wang Shiyong Zhou Eric Sandvol Jieyuan Ning Yongge Feng Mian Liu | 2010 | Earthquake Science2010，23，6： | 2 |
| 12 | Rice SPL10 positively regulates trichome development through expression of HL6 and auxin-related genes显示文摘Trichomes function in plant defenses against biotic and abiotic stresses;examination of glabrous lines,which lack trichomes,has revealed key aspects of trichome development and function.Tests of allelism in 51 glabrous rice(Oryza sativa)accessions collected worldwide identified OsSPL10 and OsWOX3B as regulators of trichome development in rice.Here,we report that OsSPL10 acts as a transcriptional regulator controlling trichome development.Haplotype and transient expression analyses revealed that variation in the approximately 700-bp OsSPL10 promoter region is the primary cause of the glabrous phenotype in the indica cultivar WD-17993.Disruption of OsSPL10 by genome editing decreased leaf trichome density and length in the NIL-HL6 background.Plants with genotype OsSPL10^(WD-17993)/HL6 generated by crossing WD-17993 with NIL-HL6 also had fewer trichomes in the glumes.HAIRY LEAF6(HL6)encodes another transcription factor that regulates trichome initiation and elongation,and OsSPL10 directly binds to the HL6 promoter to regulate its expression.Moreover,the transcript levels of auxin-related genes,such as OsYUCCA5 and OsPIN-FORMED1b,were altered in OsSPL10 overexpression and RNAi transgenic lines.Feeding tests using locusts(Locusta migratoria)demonstrated that non-glandular trichomes affect feeding by this herbivore.Our findings provide a molecular framework for trichome development and an ecological perspective on trichome functions. | Jinjie Li Bo Tang Yingxiu Li Chenguang Li Minjie Guo Haiyang Chen Shichen Han Jin Li Qijin Lou Wenqiang Sun Peng Wang Haifeng Guo Wei Ye Zhanying Zhang Hongliang Zhang Sibin Yu Long Zhang Zichao Li | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 13 | SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells显示文摘Exposure to the spike protein or receptor-binding domain(S-RBD)of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy.In this study,angiotensin-converting enzyme 2 humanized inbred(hACE2 Tg)mice and cultured pulmonary vascular endothelial cells were used to investigate how spike protein/S-RBD impacts pulmonary vascular endothelium.Results show that S-RBD leads to acute-to-prolonged induction of the intracellular free calcium concentration([Ca^(2+)]i)via acute activation of TRPV4,and prolonged upregulation of mechanosensitive channel Piezo1 and store-operated calcium channel(SOCC)key component Orai1 in cultured human pulmonary arterial endothelial cells(PAECs).In mechanism,S-RBD interacts with ACE2 to induce formation of clusters involving Orai1,Piezo1 and TRPC1,facilitate the channel activation of Piezo1 and SOCC,and lead to elevated apoptosis.These effects are blocked by Kobophenol A,which inhibits the binding between S-RBD and ACE2,or intracellular calcium chelator,BAPTA-AM.Blockade of Piezo1 and SOCC by GsMTx4 effectively protects the S-RBDinduced pulmonary microvascular endothelial damage in hACE2 Tg mice via normalizing the elevated[Ca^(2+)]i.Comparing to prototypic strain,Omicron variants(BA.5.2 and XBB)of S-RBD induces significantly less severe cell apoptosis.Transcriptomic analysis indicates that prototypic S-RBD confers more severe acute impacts than Delta or Lambda S-RBD.In summary,this study provides compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering[Ca^(2+)]i through upregulation of Piezo1 and Orai1.Targeted inhibition of ACE2-Piezo1/SOCC-[Ca^(2+)]i axis proves a powerful strategy to treat S-RBD-induced pulmonary vascular diseases. | Kai Yang Shiyun Liu Han Yan Wenju Lu Xiaoqian Shan Haixia Chen Changlei Bao Huazhuo Feng Jing Liao Shuxin Liang Lei Xu Haiyang Tang Jason X-J.Yuan Nanshan Zhong Jian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 2 |
| 14 | Service composition based on discrete particle swarm optimization in military organization cloud cooperation显示文摘This paper addresses the problem of service composition in military organization cloud cooperation(MOCC). Military service providers(MSP) cooperate together to provide military resources for military service users(MSU). A group of atom services, each of which has its level of quality of service(QoS), can be combined together into a certain structure to form a composite service. Since there are a large number of atom services having the same function, the atom service is selected to participate in the composite service so as to fulfill users' will. In this paper a method based on discrete particle swarm optimization(DPSO) is proposed to tackle this problem. The method aims at selecting atom services from service repositories to constitute the composite service, satisfying the MSU's requirement on QoS. Since the QoS criteria include location-aware criteria and location-independent criteria, this method aims to get the composite service with the highest location-aware criteria and the best-match location-independent criteria. Simulations show that the DPSO has a better performance compared with the standard particle swarm optimization(PSO) and genetic algorithm(GA). | An Zhang Haiyang Sun Zhili Tang Yuan Yuan | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 2 |
| 15 | Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008显示文摘 | Haiyang Yu Wei Chen Hongwei Chang Renshu Tang Jun Zhao Lin Gan Boyu Liu Jason Chen Mingli Wang | 2010 | Virus Genes2010，，1： | 1 |
| 16 | Comparative proteomic analysis of plasma from bipolar depression and depressive disorder: identification of proteins associated with immune regulatory显示文摘 | Jin Chen (1) (2) (3) ChengLong Huang (2) (3) (5) YiRen Song (1) (2) (3) HaiYang Shi (1) (2) (3) Dong Wu (2) (3) (5) YongTao Yang (2) (3) (4) ChengLong Rao (2) (3) (7) Li Liao (2) (3) (5) You Wu (2) (3) (6) JianYong Tang (2) (3) (5) Ke Cheng (1) (2) (3) Jian Zhou (2) (3) Peng Xie (1) (2) (3) | 2015 | Protein & Cell2015，6，12： | 1 |
| 17 | Immunoinhibitory effect of soluble HLA-G1 on the cytotoxicity of NK92 cells显示文摘HLA-G (human leukocyte antigen-G) is a non-classical HLA class I molecule, playing an important immuno-modulatory role in maintaining maternal immune tolerance of the semiallogenic fetus and organ transplantation. In this study, the cDNA sequence of extracellular domain of HLA-G1 was subcloned into the pET28a vector and a soluble 35 kD fusion protein (His-sHLA-G1) with six histine residues was obtained. In the 4 h 51Cr-release assay the fusion protein obviously inhibited the cytotoxicity of NK92 cells in a dose-dependent manner. These results indicated that sHLA-G1, as an activated immunoinhibitor, may provide an effective approach to overcoming the immune rejection of transplantation. | TIAN Xinghui, LI Zhiwei, LIU Yabing, WANG Yun, TANG Haiyang and FENG Meifu(The National Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China) | 2003 | Progress in Natural Science:Materials International2003，13，3： | 1 |
| 18 | Applications of mesenchymal stem cells labeled with Tat peptide conjugated quantum dots to cell tracking in mouse body显示文摘 | Lei Yun Tang Haiyang Yao Li-de | 2008 | Bioconjugate Chemistry2008，19，2： | 1 |
| 19 | The influence of air supply inlet location on the spatial-temporal distribution of bioaerosol in isolation ward under three mixed ventilation modes显示文摘The outbreak of COVID-19 and the spread of infectious pathogens through bioaerosols have once again aroused widespread concern worldwide.Isolation ward is an important place to prevent the spread of infectious bioaerosols.However,infection of health care workers(HCWs)in the isolation ward often occurs,so it is ur-gent to carry out relevant research to reduce the cross-infection between HCWs and patients.In this paper,the temporal and spatial distribution characteristics of bioaerosols under three mixed ventilation modes in a single ward were studied,namely,upper supply side return air of Case 1 and side supply and side return ventilation are Case 2 and Case 3 respectively.The results show that the removal efficiency of bioaerosol in the ventilation mode of Case 3,in which directional airflow is formed from the air supply inlet to the release source and then to the exhaust outlet,is 46.6%and 67.7%higher than that of Case 1 and Case 2,respectively.In addition,ventilation methods based on mixed theory do not guarantee good air quality in the breathing zone(1.3 m to 1.7 m)of HCWs,which may increase the inhalation risk for HCWs.It is hoped that our results can provide some useful suggestions for optimizing the airflow layout of the isolation ward,reducing the risk of cross-infection,and virus elimination. | Zhijian Liu Tianci Wang Yongxin Wang Haiyang Liu Guoqing Cao Song Tang | 2023 | Energy and Built Environment2023，4，4： | 1 |
| 20 | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function显示文摘 | Ya Guo Quan Xu Daniele Canzio Jia Shou Jinhuan Li David U. Gorkin Inkyung Jung Haiyang Wu Yanan Zhai Yuanxiao Tang Yichao Lu Yonghu Wu Zhilian Jia Wei Li Michael Q. Zhang Bing Ren Adrian R. Krainer Tom Maniatis Qiang Wu | 2015 | Cell2015，，： | 1 |
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