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| 1 | Cyclooxygenase-2 and the inflammogenesis of breast cancer显示文摘Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) COX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to COX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of COX-2 and PGE-2 expression induces transcription of CYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic CYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit COX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of COX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of COX-2 and the prostaglandin cascade in the 'inflammogenesis of breast cancer'. | Randall E Harris Bruce C Casto Zachary M Harris | 2014 | World Journal of Clinical Oncology2014，5，4： | 15 |
| 2 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 3 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 4 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 5 | A型肉毒素局部注射治疗慢性腰背痛显示文摘目的探讨A型肉毒素局部注射治疗以腰背肌痉挛型为主的慢性腰背痛的临床疗效。方法对路易斯安娜州立大学疼痛中心9例诊断为神经肌肉综合征和腰骶神经根炎的慢性腰背痛患者给予局部注射A型肉毒素治疗。采用McGill疼痛评分、Oswestry & Roland-Morris失能评分、腰背肌肌肉痉挛评分以及功能运动范围对患者进行疗效评定。临床观察参数采集于病人转诊、第一次门诊和之后的随访治疗中。结果9例患者中,McGill疼痛评分改善7例,Oswestry & Roland-Morris失能评分改善5例,腰背肌肌肉痉挛评分改善7例,腰部运动功能改善4例。结论A型肉毒素局部注射是治疗以腰背肌痉挛为主的慢性腰背痛的有效方法。 | Bill Subin Randall C Cork Frank Zavisca | 2009 | 中国骨科临床与基础研究杂志2009，1，2： | 3 |
| 6 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 7 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 8 | A ^13C NMR Determination of the comonomer sequence distribution in propylene- butene-1 copolymers显示文摘 | James C Randall | 1978 | Macromolecules1978，11，3： | 1 |
| 9 | Bidding games for valuation of aesthetic environmental improvements显示文摘 | RANDALL A IVES B EASTMAN C | 1974 | Journal of Environmental Economics and Management1974，，1： | 1 |
| 10 | 1997 CEO perspectives on the current status and future prospects of the third party logistics industry in the United States显示文摘 | Lieb R C Randall H L | 1999 | Transportation Journal1999，，3： | 1 |
| 11 | Demonstration of hormesis (increase in fatality rate)by penicillin显示文摘 | Randall W A Price C W Welch H | 1947 | American Journal of Public Health and the Nations Health1947，37，4： | 1 |
| 12 | Sacral resection and reconstruction for tumors and tumor-like conditions 显示文摘 | Randall RL Bruckner J Lloyd C | 2005 | Orthopedics2005，28，3： | 1 |
| 13 | Evaluation of integrated fixedfilm activated sludge wastewater treatment processes at high mean cells residence time and low temperatures显示文摘 | Tongchai Sriwiriyarat Randall C W | 2005 | Journal of Environmental Engineering2005，131，11： | 1 |
| 14 | Phase relations and dielectric properties in the Bi2O3-ZnO-Ta2O5 system显示文摘 | YOUN H J SOGABE T RANDALL C A | 2001 | J Am Ceram Soc2001，84，11： | 1 |
| 15 | Assimilable organic carbon (AOC) and biodegradable dissolved organic carbon (BDOC) : complementary measurements 显示文摘 | ESCOBAR I C RANDALL A A | 2001 | Wat Res2001，35，18： | 1 |
| 16 | Observations on swollen head syndrom in broiler and broiler breeder chickens显示文摘 | Pattison M Chettle N Randall C J | 1989 | Vet Rec1989，125，： | 1 |
| 17 | Nitrate versus Oxygen Respiration in the Activated Sludge Process显示文摘 | McClintock S A Sherrard J H Novak J T Randall C W | 1988 | Journal WPCF1988，60，3： | 1 |
| 18 | Bacterial growth in distri- bution systems Effect of assimilable organic carbon and biode- gradable dissolved organic carbon显示文摘 | Escobar I C Randall A A Taylor J S | 2001 | Environmental Science -Technology2001，35，17： | 1 |
| 19 | Amplification of padlock probes for DNA diagnostics by cascade rolling circle amplification or the polymerase chain reaction 显示文摘 | THOMAS D C NARDONE G A RANDALL S K | 1999 | Archives of Pathology & Laboratory Medicine1999，123，12： | 1 |
| 20 | Effects of sulphur supply on the yield, composition and quality of grain from cereals, oil seeds and legumes 显示文摘 | RANDALL P J WRIGLEY C W | 1986 | Advance in Cereal Science1986，8，： | 1 |
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