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| 1 | Robot-assisted radical cystectomy and intracorporeal orthotopic neobladder: 1-year functional outcomes显示文摘Complete intracorporeal urinar y diversion(ICUD)with an orthotopic neobladder is an emerging procedure.The objective of this article was to assess retrospectively the urodynamic and continence results after robot-assisted radical cystectomy(RARC)and ICUD with a modified orthotopic Studer neobladder.After a median follow-up time of 11 months,all patients were socially continent(≤1 pad)at daytime.Median Pouch capacity was 404 ml with a median postvoid residual volume of 0 ml.All patients stated that they would choose the same type of urinary diversion again.RARC and ICUD with orthotopic neobladder provides promising functional and urodynamic results with high patient satisfaction. | Fabian Obrecht Nadim Abo Youssef Orlando Burkhardt Christoph Schregel Marco Randazzo Christian Padevit Peter Wiklund Hubert John | 2020 | Asian Journal of Andrology2020,22,2: | 4 |
| 2 | Novel biomarkers of acute kidney injury: Evaluation and evidence in urologic surgery显示文摘Patients undergoing urologic surgery are at risk of acute kidney injury(AKI) and consequently longterm deterioration in renal function. AKI is further associated with significantly higher odds of perioperative complications, prolonged hospital stay, higher mortality and costs. Therefore, better awareness and detection of AKI, as well as identification of AKI determinants in the urological surgery setting is warranted to pre-empt and mitigate further deterioration of renal function in patients at special risk. New consensus criteria provide precise definitions of diagnosis and description of the severity of AKI. However, they rely on serum creatinine(SCr), which is known to be an inaccurate marker of early changes in renal function. Therefore, several new urinary and serum biomarkers promise to address the gap associated with the use of SCr. Novel biomarkers may complement SCr measurement or most likely improve the diagnostic accuracy of AKI when used in combinations. However, novel biomarkers have to prove their clinical applicability, accuracy, and cost effectiveness prior to implementation into clinical practice. Most preferably, novel biomarkers should help to positively improve a patient's long-term renal functional outcomes. The purpose of this review is to discuss currently available biomarkers and to review their clinical evidence within urologic surgery settings. | Marianne Schmid Deepansh Dalela Rana Tahbaz Jessica Langetepe Marco Randazzo Roland Dahlem Margit Fisch Quoc-Dien Trinh Felix K-H Chun | 2015 | World Journal of Nephrology2015,4,2: | 3 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018,17,4: | 2 |
| 4 | 中国汽车行业的跨公司协同项目管理显示文摘基于对中国当前汽车行业项目环境的分析,认为专业化项目管理对跨公司协作的控制极为重要,提出了实施跨公司协同项目管理的重要性和必要性,并分析了取得跨公司协同项目管理成功的关键因素和应注意的问题。 | Antonio Randazzo 蔡惠 | 2008 | 项目管理技术2008,,3: | 2 |
| 5 | A four-channel,low-power CMOS charge preamplifier for silicon detectors with medium value of capacitance显示文摘 | RANDAZZO N RUSSO G V PRESTI D L | 1997 | IEEE Transactions on Nuclear Science1997,44,1: | 1 |
| 6 | Evaluation of the vascular targeting agent combretastatin A-4 prodrug on retinal neovascularization in the galaetose-fed dog 显示文摘 | Kador PF Blessing K Randazzo J | 2007 | J Ocul Pharmacol Ther2007,23,2: | 1 |
| 7 | Pecorino Crotonese cheese: Study of bacterial population and flavour compounds显示文摘 | C.L. Randazzo I. Pitino A. Ribbera C. Caggia | 2009 | Food Microbiology2009,,3: | 1 |
| 8 | Diversity,dynamics,and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | Randazzo C L Torriani S Antoon D L | 2002 | Appl Environ Microbiol2002,68,4: | 1 |
| 9 | Direction of arrival estimation based on support vector regression: Experimental validation and comparison with MUSIC 显示文摘 | Randazzo A Abou-Khousa M A Pastorino M | 2007 | IEEE Antennas and Wireless Propagation Letters2007,6,37: | 1 |
| 10 | Role of surfactants in optimizing fluoreue assimilation and intermediate formation by rhodochrous VKMB-2469 显示文摘 | KOLOMYTSEVA M P RANDAZZO D BASKUNOV B P | 2009 | Bioresource Technology2009,100,: | 1 |
| 11 | Arf GAPs: multifunctional proteins thatregulate membrane traffic and actin remodelling 显示文摘 | Randazzo P A Hirsch D S | 2004 | Cell Signal2004,16,4: | 1 |
| 12 | Diversity,dynamies, and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis 显示文摘 | Randazzo CL Torriani S Akkermans AD | 2002 | Appl Enivron Microbiol2002,68,4: | 1 |
| 13 | Tiagabine is associated with sustained attention during sleep restriction: Evidence for the value of slow-wave sleep enhancement 显示文摘 | Walsh JK Randazzo AC Stone K | 2006 | Sleep2006,29,4: | 1 |
| 14 | Diversity,dynamics,and activity of bacterial communities during production of anartisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | RANDAZZO C L TORRIANI S AKKERMANS A D L at el | 2002 | ApplEnviron Microbiol2002,68,4: | 1 |
| 15 | Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms显示文摘 | Iyer SS Randazzo BP Tzanis EL | 2011 | Value Health2011,14,1: | 1 |
| 16 | Lamotrigine adjunctive therapy in painful phenomena in MS: preliminary observations显示文摘 | zuddas A Randazzo AR | 1999 | Neurology1999,53,: | 1 |
| 17 | Artisanal and experi-mental Pecorino Siciliano cheese:microbial dynamics during manufac-ture assessed by culturing and PCR-DGGE analyses显示文摘 | RANDAZZO C L VAUGHAN E E CAGGIA C | 2006 | Int J FoodMicrobiol2006,109,12: | 1 |
| 18 | GEFH1 binds ASAP1 and regu-lates podosome formation显示文摘 | Shiba Y Randazzo PA | 2011 | Biochem Biophys Res Com-mun2011,406,4: | 1 |
| 19 | Pecorino Crotonesecheese: Study of bacterial population and flavour compounds 显示文摘 | RANDAZZO CL PITINO I RIBBERA A | 2010 | FoodMicrobiol2010,27,3: | 1 |
| 20 | Fluoroquinolone - induced liver injury:three new cases and a review of the literature显示文摘 | Licata A Randazzo C Morreale I | 2012 | Euro- pean Journal of Clinical Pharmacology2012,68,5: | 1 |