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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Space science applications of cryogenic detectors显示文摘 | Rando N Lumb D Bavdaz M | 2004 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and As- sociated Equipment2004，522，12： | 1 |
| 3 | Emerging models and paradigms for stem cell ageing显示文摘 | Jones D L Rando T A | 2011 | Nat Cell Biol2011，13，5： | 1 |
| 4 | Periodic lateralized epileptiform discharges (PLEDs) as early indicator of stroke in full-term newborns显示文摘 | Rando T Ricci D Mercuri E | 2000 | Neuropediatri cs2000，31，4： | 1 |
| 5 | Space science applications of cryogenic detectors 显示文摘 | RANDO N LUMB D BAVDAZ M | 2004 | Nuclear Instruments & Methods in Physics Research A2004，522，： | 1 |
| 6 | The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis 显示文摘 | Luo D Renault V M Rando T A | 2005 | Semin Cell Dev Biol2005，16，4： | 1 |
| 7 | Flexible uretemrenoscopy(URS) : technique and results显示文摘 | Cansino Alcaide JR Reinoso Elbers J Lopez Sanchez D Perez Gonzalez S Rodriguez Aguilera Bazan A Rando Tous A Hidalgo Togores L De La Pena Barthel J | 2010 | Arch Esp Urol2010，63，10： | 1 |
| 8 | Overexpression of Deltex2 inhibits mouse muscle cell differentiation显示文摘 | Luo D Rando T A | 2004 | Mol Biol Cell2004，15，： | 1 |
| 9 | Production, purification and characterization of glucose oxidase from a newly isolated strain of PeniciUium pinophilum显示文摘 | RANDO D KOHRING G W GIFFHORN F | 1997 | Applied Microbiology and Biotechnology1997，48，1： | 1 |
| 10 | The regulation of Notch signaling inmuscle stem cell activation and postnatal myogenesis显示文摘 | Luo D Renault VM Rando TA | 2005 | Semin Cell Dev Biol2005，16，45： | 1 |
| 11 | The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis显示文摘 | Luo D Renault VM Rando TA | 2005 | Semin Cell Dev Biol2005，16，45： | 1 |
| 12 | A functional evolu- tionary approach to identify determinants of nucleosome posi- tioning: a unifying model for establishing the genome-wide pattern显示文摘 | HUGHES A L JIN Y RANDO O J et d | 2012 | Molecular Cell2012，48，1： | 1 |
| 13 | Production,purification and characterization of glucose 1245 oxidase from a newly isolated strain of Penicillium pinophilum显示文摘 | RANDO D KOHRING G W GIFFHORN F | 1997 | Appl Microbiol Biotechnol1997，48，1： | 1 |
| 14 | Irreversible inhibition of glutamate decarboxylnse by alpha-(fluoromethyl) glutamic acid显示文摘 | KOU D RANDO R R | 1981 | Biochemistry1981，20，3： | 1 |
| 15 | Production, purification and characterization of glucose 1245 oxidase from a newly isolated strain of Penicillium pinophilum 显示文摘 | Rando D Kohring G W Giffhom F | 1997 | Appl Microbiol Biotechnol1997，48，1： | 1 |
| 16 | Changes in mandibular dimensions during the mediaeval to post-mediaeval transition in London : a pos- sible response to decreased masticatory load 显示文摘 | Rando C Hillson S Antoine D | 2014 | Arch Oral Biol2014，59，1： | 1 |
| 17 | Production, purificationand characterization of glucose oxidase from a newly isolated strain ofPenicillium pinophilum显示文摘 | RANDO D KOHRING G W GIFFHORN F | 1997 | Applied Microbiology and Biotechnology1997，48，1： | 1 |
| 18 | Assessment study of the SPICA telescope assembly 显示文摘 | RANDO N BRUNNER O DOYLE D | 2009 | SPIE2009，7436，74： | 1 |
| 19 | The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis显示文摘 | Luo D Renault VM Rando TA | 2005 | Semin Cell Dev Biol2005，16，45： | 1 |
| 20 | Stability-activity relationship of a family of G-tetrad forming oligonucleotides as potent HIV inhibitors显示文摘 | Jing N Clercq E D RANDO R F | 2000 | J Biol Chem2000，275，5： | 1 |
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