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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature 显示文摘 | Rappold G Fukami M Niesler B | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 3 | Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporte' 3显示文摘 | Rappold PM Cui M Chesser AS | 2011 | Proc Natl Acad Sci U S A2011，108，20： | 1 |
| 4 | Deletions of the homeobox gene SHOX (short stature homeobox ) are an important cause of growth failure in children with short stature 显示文摘 | Rappold G Fukami M Niesler B | 2002 | J Clin Endocrinol Metab2002，873，： | 1 |
| 5 | Critical role of aquapor- in-4 (AQP4) in astrocytie Ca^2+ signaling events elicited by cerebraledema 显示文摘 | Thrane A S Rappold P M Fujita T | 2011 | Proc Nail Acad Sci USA2011，108，2： | 1 |
| 6 | Integrated shared earth model: 3D pore-pressure prediction and uncertainty analysis显示文摘 | Lopez J L Rappold P M | 2004 | The Leading Edge2004，23，1： | 1 |
| 7 | Astrocytes and therapeutics for Par- kinson' s disease 显示文摘 | Rappold P M Tieu K | 2010 | Neurotherapeutics2010，7，4： | 1 |
| 8 | Gp130-signaling synergizes with FL and TPO for the long-term expansion of cord blood progenitors显示文摘 | Rappold I Watt S M Kusadasi N | 1999 | Leukemia1999，13，12： | 1 |
| 9 | Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3显示文摘 | RAPPOLD P M CUI M CHESSER A S | 2011 | Proc Natl Acad Sci USA2011，108，20： | 1 |
| 10 | Comparative plateletproteome analysis reveals an increase of monoamine oxidase-Bprotein expression in Alzheimer,s disease but not in non-dementedParkinson,s disease patients显示文摘 | Zellner M Baureder M Rappold E | 2012 | J Proteomics2012，75，： | 1 |
| 11 | Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3显示文摘 | Rappold PM Cui M Chesser AS | 2011 | Proe Natl Aead Sei USA2011，108，20： | 1 |
| 12 | Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature显示文摘 | Rappold G A Fukami M Niesler B | 2002 | Journal of Clinical Endocrinology and Metabolism2002，87，3： | 1 |
| 13 | Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation trans- porter-3显示文摘 | Rappold PM Cui M Chesser AS | 2011 | Proc Natl Acad Sci USA2011，108，20： | 1 |
| 14 | P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain 显示文摘 | Rappold P M Lynd-Balta E Joseph S A | 2006 | Brain Res2006，1089，1： | 1 |
| 15 | Temporal trends and spatial distribution of PCDD, PCDF, and PCB in pine and spruce shoots 显示文摘 | Rappolder M Schroter-Kermani C Schadel S Waller U Komer W | 2007 | Chemosphere2007，67，： | 1 |
| 16 | Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema 显示文摘 | Thrane A S Rappold P M Fujita T | 2011 | Proc Natl Acad Sei U S A2011，108，2： | 1 |
| 17 | Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3 显示文摘 | Rappold PM Cui M Chesser AS | 2011 | Proc Natl Acad Sci U S A2011，108，20： | 1 |
| 18 | Cardio- vascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null hu- man volunteers显示文摘 | TONG H RAPPOLD A G CAUGHEY M | 2014 | Inhal Toxicol2014，26，6： | 1 |
| 19 | Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature 显示文摘 | Rappold G A Fukami M Niesler B | 2002 | J Clin Endocrinol Metab2002，87，3： | 1 |
| 20 | Paraqaat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3 显示文摘 | RAPPOLD P M CUI M CHESSER A S | 2011 | Proc Natl Acad Sci U S A2011，108，20： | 1 |
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