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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Stromal expression of SPARC in pancreatic adenocarcinoma显示文摘 | Cindy Neuzillet Annemila? Tijeras-Raballand Jér?me Cros Sandrine Faivre Pascal Hammel Eric Raymond | 2013 | Cancer and Metastasis Reviews (-)2013，，3： | 4 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | Myocardial infarction and normal coronary arteriography:a 10 year clinical and risk analysis of 74 patients显示文摘 | Raymond R Lynch J Underwood D | 1988 | J Am Coll Cardiol1988，11，3： | 1 |
| 5 | Tolerance,effectiveness,and acceptability of sulfate free elect rolyte lavage solution for colon cleaning before colonoscopy显示文摘 | Raymond J M Beyssac R Capdenat E | 1996 | Endoscopy1996，28，7： | 1 |
| 6 | LumpedModel Analysis of Microcircuit Vulnerability显示文摘 | J P Raymond W W Chang R E Budris | | 0，，06： | 1 |
| 7 | In situ synthesis of ferrites in cellulosics显示文摘 | Raymond L Revol J F Marchessault R | 1994 | Chemitry of Materials1994，6，： | 1 |
| 8 | An educational framework to support gerontological nursing education at the baccalaureate level显示文摘 | Plowfield L A Raymond J E Hayes E R | 2006 | J Prof Nuts2006，22，2： | 1 |
| 9 | In situ synthesis of ferrites in ionic and neutral cellulose gels显示文摘 | Raymond L Revol J F Marchessault R | 1995 | Poly-mer1995，36，26： | 1 |
| 10 | Expression of Draft1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development显示文摘 | Raymond C S Kettlewell J R Hirsch B | 1999 | Dev Biol1999，215，2： | 1 |
| 11 | Nuerical analysis of thermal response with a groundwater flow and heat transfer model显示文摘 | Raymond J Therrien R Gossen L | 2011 | Renewable Energy2011，36，1： | 1 |
| 12 | Differential scanning calorimetry of meat proteins as affected by processing treatment显示文摘 | QUINN J R RAYMOND D P HARWALKER V R | 1980 | Journal of Food Science1980，45，5： | 1 |
| 13 | In situ synthesis of ferrites in ionic and neutral cellulose gels显示文摘 | L Raymond J P Revol R H Marchossault | 1995 | Polymer1995，36，26： | 1 |
| 14 | Synthesis and properties of fatty imidazolines and their N-(2-aminoethyl) derivatives显示文摘 | Raymond G B J R James W H | 1983 | Journal of the American ChemicalSociety1983，80，4： | 1 |
| 15 | 查看详情显示文摘 | Schuch R Garibian A Nygaard P Raymond S Araik G Hans H S Patrick J P Per N | | 0，，： | 1 |
| 16 | Hydrological discharges and motion of fels and Black-Rapids Glaciers, Alaska, USA-Implications for the structure of their drainage systems 显示文摘 | Raymond C F Benedict R J Harrison W D | 1995 | Journal of Glaciology1995，41，138： | 1 |
| 17 | Natural outbreak of viral encephalopathy and retinopathy in juvenile sea bass Dicentrarchus labrax: study by nested reverse transcriptase-polymerase chain reaction 显示文摘 | Thiery R Raymond J C Castric J | 1999 | Virus Research1999，63，： | 1 |
| 18 | Triaxial tests on dolomite railroad ballast显示文摘 | Raymond G P Davies J R | 1978 | Journal of Soil Mechanics and Foundation Division American Society of Civil Engineering1978，104，6： | 1 |
| 19 | Temperaturedependent expression of turtle Dmrtl prior to sexual differentiation 显示文摘 | Kettlewell J R Raymond C S Zarkower D | 2000 | Genesis2000，26，： | 1 |
| 20 | Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension 显示文摘 | Raymond R J Hinderliter AL Wills PW | 2002 | J Am Coil Cardiol2002，39，7： | 1 |
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