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| 1 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 2 | Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocininduced diabetic rats显示文摘Objective: To evaluate the antidiabetic and antioxidant ef ects of aqueous ethanolic extract of Caesalpinia ferrea(C. ferrea) leaf in normal and streptozotocin(STZ) induced diabetic rats.Methods: Male Sprague-Dawley rats divided into 6 groups of 6 rats each were assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ(65 mg/kg body weight). C. ferrea extract at the doses of 250 and 500 mg/kg body weight was orally administered to both diabetic and non-diabetic animals for a period of 30 days. After completion of experimental duration serum, liver and pancreas were used for evaluating biochemical and histopathological changes.Results: Oral administration of C. ferrea leaf extract significantly reduced elevated serum glucose, α-amylase, liver function levels and signii cantly increased serum insulin, total protein and body weight as well as improved lipid proi le due to diabetes. Furthermore, the treatment resulted in a marked increase in glutathione peroxidase, superoxide dismutase, catalase and reduced glutathione, and diminished levels of lipid peroxidation in liver and pancreas of diabetic rats. Histopathological studies demonstrated the reduction in the pancreas and liver damage and coni rmed the biochemical i ndings.Conclusions: From the present study, it can be concluded that the C. ferrea leaf extract ef ectively improved hyperglycaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. Hence, it can be used in the management of diabetes mellitus. | Sherien Kamal Hassan Nermin Mohammed El-Sammad Amria Mamdouh Mousa Maha Hashim Mohammed Abd el Razik Hussein Farrag Amani Nassir Eldin Hashim Victoria Werner Ulrike Lindequist Mahmoud Abd El-Moein Nawwar | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 3 |
| 3 | Detection and diagnosis of faults in induction motor using an improved artificial ant cluste- ring technique显示文摘 | SOUALHI A CLERC G RAZIK H | 2013 | IEEE Transactions on Industrial Electronics2013，60，9： | 1 |
| 4 | Early prediction of response to recombinate human erythripoietin in patients with the anemia of renal failure by serum transferring receptor and fib rinogen显示文摘 | Beguin Y Loo M Raziks | 1993 | Blood1993，82，： | 1 |
| 5 | Physicians’ Perceptions of Risks and Practices in Venous Thromboembolism Prophylaxis in Inflammatory Bowel Disease显示文摘 | Justina J. Sam Charles N. Bernstein Roshan Razik Reka Thanabalan Geoffrey C. Nguyen | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 6 | Use of a standard reference material for precise lattice parameter determination of materials of hexagonal crystal structure显示文摘 | N. A. Razik | 1987 | Journal of Materials Science Letters1987，，12： | 1 |
| 7 | Molecular interplay between ion channels and the regulation of apoptosis显示文摘 | Razik MA Cidlowski JA | 2002 | Biol Res2002，35，2： | 1 |
| 8 | Dangerousness and management of delusional misidentification syndrome显示文摘 | Aziz MA Razik GN Donn JE | 2005 | Psychopathology2005，38，2： | 1 |
| 9 | 5α, 8α-Epidioxysterols from the gorgonian Eunieell cavolini and the ascidian Trididemnum inarmatum : i- solation and evaluation of their antiproliferative activity 显示文摘 | Ioannou E Abdel Razik A F Zervou M Christofidis D Alexi X Vagias C | 2009 | Steroids2009，74，： | 1 |
| 10 | On-line efficiency opti- mization of a synchronous reluctance motor 显示文摘 | Lubin T Razik H Rezzoug A | 2007 | Electric Power Systems Research2007，77，56： | 1 |
| 11 | Synthesis of some pyrazolines and pyrimidines derived from polymethoxy chalcones as anticancer and antimicrobial agents显示文摘 | Rostom S A F Badr M H Razik H A | | 0，，： | 1 |
| 12 | Comparison between finite-element analysis and winding function theory for inductances and torque calculation of a synchronous reluctance machine显示文摘 | Lubin T Hamiti T Razik H | 2007 | IEEE Transactions on Magnetics2007，43，8： | 1 |
| 13 | On the modeling and design of dual-stator windings to minimize circulating harmonic currents for VSI fed AC machines 显示文摘 | HADIOUCHE D RAZIK H REZZOUG A | 2004 | IEEE Transactions on IndustrialApplications2004，40，50： | 1 |
| 14 | 5a, 8a-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: Isolation and evaluation of their antiproliferative activity显示文摘 | Ioannou E Abdel- Razik AF Zervou M | 2009 | Steroids2009，74，1： | 1 |
| 15 | Time to internal fixation of femoral neck fractures in patients under sixty years—does this matter in the development of osteonecrosis of femoral head?显示文摘 | Fathima Razik Anastasia-Stefania Alexopoulos Bassel El-Osta Michelle J. Connolly Ashley Brown Soueid Hassan Kasetti Ravikumar | 2012 | International Orthopaedics2012，，10： | 1 |
| 16 | Analytical approach of the stator current frequency harmonics computation for detection of induction machine rotor faults 显示文摘 | Henao H Razik H Capolino G A | 2005 | IEEE Trans Ind Applicat2005，，41： | 1 |
| 17 | An investigation of manganese partitioning during the austenitic-pearlite transformation using analytical electron microscopy显示文摘 | Razik N A Lorimer G W Ridley N | 1974 | Acta Metallurgica1974，22，10： | 1 |
| 18 | Emotion enhanced retention of cognitive skill learning显示文摘 | Steidl S Razik F Anderson AK | 2011 | Emotion2011，11，1： | 1 |
| 19 | Rotor cage fault detection in induction motor using global modulation index on the instantaneous power spectrum,in Proceedingof Symposum Diagnostics Electric Machines显示文摘 | DIDIER G RAZIK H CASPARY O | 2003 | Power Electronics and Drives(SDEMPED)2003，，： | 1 |
| 20 | Analytical approach of the stator current frequency harmonics computation for detection of induction machine rotor faults 显示文摘 | Henao H Razik H Capolino G A | 2005 | IEEE Transactions on Industry Applications2005，41，3： | 1 |
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