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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 3 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 4 | 一株耐盐植物内生真菌的筛选与鉴定显示文摘[目的]研究盐田原生态系统中的耐盐植物内生真菌。[方法]对38株从海南省莺歌海盐场和东方盐场分离的菌株进行耐盐生长测试。[结果]发现了1株在8%Na Cl浓度下生长较好的真菌,并根据其形态特征,ITS扩增序列聚类进化树分析,显示其分类地位为黑酵母菌(Hortaea werneckii)。经过高效液相色谱分析其代谢产物,发现该真菌在0、2%、4%、8%Na Cl浓度下的发酵产物均有所不同。[结论]盐田生境中存在特殊的植物内生真菌区系,其中黑酵母菌Hortaea werneckii具有一定代表性,有深入研究的价值。 | 孙海彦 尹慧祥 陈惠琴 王琪 Marilyn Roossinck Regina S Redman Rusty Rodriguez 包晓东 | 2018 | 安徽农业科学2018，46，19： | 2 |
| 5 | Current strategies {or articular cartilage repair显示文摘 | REDMAN S N OLDFIELD S F ARCHER C W | 2005 | European Cells b- Materials2005，9，： | 1 |
| 6 | Uhrastructure and morphogenesis of white spot syndrome baculovirus (WSSV) 显示文摘 | Durand S Lightner D V Redman R M | 1997 | Dis Aquat Org1997，29，： | 1 |
| 7 | Relationships of nurses assessment of organizational culture,job satisfaction and patient satisfaction with nursing care显示文摘 | Tzeng HM Ketefian S Redman RW | 2002 | International Journal of Nursing Studies2002，39，11： | 1 |
| 8 | Relationship of Nurses assessment of organizational culture job satisfaction and patient satisfaction with Nursing care 显示文摘 | Tzeng HM Ketefain S Redman RW | 2002 | International Journal of nursing studies2002，39，11： | 1 |
| 9 | The role of fungal symbioses in the adaptation of plant to high stress environments显示文摘 | RODRIGUEZ R J REDMAN R S HENSON J M | 2004 | Mitigat Adaptat Strateg Glob Change2004，9，3： | 1 |
| 10 | Qualitative and quantitative studies on the relative virus load of tails and heads of shrimp acutely infected with WSSV显示文摘 | Durand S V Redman R M | 2003 | Aquaculture2003，216，14： | 1 |
| 11 | Current strategies for articular car- tilage repair显示文摘 | Redman S N Oldifeld S F | 2005 | Eur Cell Mater2005，9，： | 1 |
| 12 | Biochemical analysis of plant protection afforded by a nonpathogenic endophytic mutant of Col- letotrlchum magna 显示文摘 | Redman R S Freeman S Clifton D R | 1999 | Plant Physiology1999，119，2： | 1 |
| 13 | Fungal symbiosis:from mutualism to parasitism,who control the outcome,host or invader显示文摘 | Dunigan D D Rodriguez R J | 2001 | New Phytologist2001，151，3： | 1 |
| 14 | On approaches to the functional res- toration of salivary glands damaged by radiation ther- apy for head and neck cancer, with a review of related aspects of salivary gland morphology and development 显示文摘 | REDMAN R S | 2008 | Biotech Histochem2008，83，： | 1 |
| 15 | Measring soil water content with ground penetrating radar: A review 显示文摘 | Huisman J A Hubbard S S Redman J D | 2003 | Vadose Zone J2003，，2： | 1 |
| 16 | Thermotolerance generated by plant/fungal symbiosis显示文摘 | Sheehan K B Stout R G | 2002 | Science2002，298，5598： | 1 |
| 17 | The surface of articular cartilage contains a progenitor cell population显示文摘 | Dowthwaite G Bishop J Redman S | 2004 | J Cell Sci2004，117，： | 1 |
| 18 | Role of cell surface lipopolysac- eharides in Escherichia coli K12 adhesion and transport显示文摘 | Walker S L Redman J A Elimelech M | 2004 | Langmuir2004，20，18： | 1 |
| 19 | Thermotolerance generated by plant/fungal symbiosis 显示文摘 | Redman R S Sheehan K B Stout R G | 2002 | Science2002，298，： | 1 |
| 20 | Relationship of nurses' assessment of organizational culture, job satisfaction, and patient satisfaction with nursing care显示文摘 | Tzeng HM Ketefian S Redman RW | 2002 | Int J Nuts Stud2002，，： | 1 |
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