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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | Review of inverse analysis for indirect measurement of impact force显示文摘 | Inoue H Harrigan J J Reid S R | 2001 | Applied Mechanics Review2001，54，6： | 2 |
| 5 | Investigation into the biological stability of collagen/chondroitin-6-sulphate gels and their contraction by fibroblasts and keratinocytes: the effect of crosslinking agents and diamines显示文摘 | Osborne C S Reid W H Grant M H | 1999 | Biomaterials1999，20，3： | 1 |
| 6 | Indentation penetration and perforation of composite laminates and sandwich panels under quasi-static and projectile loading显示文摘 | Wen H M Reddy T Y Reid S R | 1998 | Key Eng Mater1998，，1： | 1 |
| 7 | Context Effects in Subjective Mental Workload Ratings 显示文摘 | Colle H A Reid G B | 1998 | Human Factors1998，40，4： | 1 |
| 8 | Low-quality employment concentration and crime: an examination of metropolitan labor markets显示文摘 | Weiss H E Reid L W | 2005 | Sociological Perspectives2005，48，2： | 1 |
| 9 | Local impact effects of hard missiles on concrete targets 显示文摘 | LI Q M REID S R WEN H M | 2005 | Int J Impact Eng2005，32，： | 1 |
| 10 | Environmental influences on bamboo Bashania fangiana growth and implications for giant panda conservation 显示文摘 | Reid D G Taylor A H Hu J C | 1991 | Journal of Applied Ecology1991，28，： | 1 |
| 11 | Water vapor transmission rates in burns and chronic leg ulcers:influence of wound dressings and comparison with in vitro evaluation显示文摘 | Wu P Nelson E A Reid W H | 1996 | BiomateriaIs1996，17，14： | 1 |
| 12 | Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan显示文摘 | Dixon IM Ju H Reid NL | 1997 | J Mol Cell Cardiol1997，29，7： | 1 |
| 13 | Penetration and perforation of composite sandwich panels by hemispherical and conical projectiles显示文摘 | Reddy T Y Wen H M Reid S R | 1998 | Trans ASME J Pres Ves Tech1998，120，2： | 1 |
| 14 | Gender-specific association of sleep duration with blood pressure in rural Chinese adults显示文摘 | Wang H Zee r Reid K | 2011 | Sleep Med2011，12，7： | 1 |
| 15 | Microbio- ta restoration: natural and supplemented recovery of human microbial communities显示文摘 | REID G YOUNES J A VAN DER MEI H C | 2011 | Nat Rev Microbiol2011，9，1： | 1 |
| 16 | Deformation and failure of clamped beams under low speed impact loading 显示文摘 | Wen H M Reddy T Y Reid S R | 1995 | Int J Impact Eng1995，16，3： | 1 |
| 17 | Effect of time of harvest of budded virus on the selection of baculovirus F P mutants in cell culture显示文摘 | Lua L H Reid S | 2003 | Biotechnol Prog2003，19，： | 1 |
| 18 | Development of a TaqMan PCR assay with internal amplification control lbr the detection of African swine fever virus 显示文摘 | King D P Reid S M Hutching G H | 2003 | J Virol Methods2003，107，： | 1 |
| 19 | Deepwater drilling made more efficient and cost effective: using the microflux control method and an ultralow-invasion fluid to open the mud weight window显示文摘 | SANTOS H REID H MCCASKILL J | 2007 | SPE Drilling & Completion2007，22，18： | 1 |
| 20 | LYVE-l-positive maerophages are present in normal murine eyes显示文摘 | XU H CHEN M REID D M | 2007 | Invest Ophthalmol Vis Sci2007，48，： | 1 |
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