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| 1 | Stem cell therapy for Parkinson’s disease: safety and modeling显示文摘For decades,clinicians have developed medications and therapies to alleviate the symptoms of Parkinson’s disease,but no treatment currently can slow or even stop the progression of this localized neurodegeneration.Fortunately,sparked by the genetic revolution,stem cell reprogramming research and the advancing capabilities of personalization in medicine enable forward-thinking to unprecedented patient-specific modeling and cell therapies for Parkinson’s disease using induced pluripotent stem cells(iPSCs).In addition to modeling Parkinson’s disease more accurately than chemically-induced animal models,patient-specific stem cell lines can be created,elucidating the effects of genetic susceptibility and sub-populations’differing responses to in vitro treatments.Sourcing cell therapy with iPSC lines provides ethical advantages because these stem cell lines do not require the sacrifice of human zygotes and genetically-specific drug trails can be tested in vitro without lasting damage to patients.In hopes of finally slowing the progression of Parkinson’s disease or re-establishing function,iPSC lines can ultimately be corrected with gene therapy and used as cell sources for neural transplantation for Parkinson’s disease.With relatively localized neural degeneration,similar to spinal column injury,Parkinson’s disease presents a better candidacy for cell therapy when compared to other diffuse degeneration found in Alzheimer’s or Huntington’s Disease.Neurosurgical implantation of pluripotent cells poses the risk of an innate immune response and tumorigenesis.Precautions,therefore,must be taken to ensure cell line quality before transplantation.While cell quality can be quantified using a number of assays,a yielding a high percentage of therapeutically relevant dopaminergic neurons,minimal de novo genetic mutations,and standard chromosomal structure is of the utmost importance.Current techniques focus on iPSCs because they can be matched with donors using human leukocyte antigens,thereby reducing the severity and risk of immune rejection.In August of 2018,researchers in Kyoto,Japan embarked on the first human clinical trial using iPSC cell therapy transplantation for patients with moderate Parkinson’s disease.Transplantation of many cell sources has already proven to reduce Parkinson’s disease symptoms in mouse and primate models.Here we discuss the history and implications for cell therapy for Parkinson’s disease,as well as the necessary safety standards needed for using iPSC transplantation to slow or halt the progression of Parkinson’s disease. | Theo Stoddard-Bennett Renee Reijo Pera | 2020 | Neural Regeneration Research2020，15，1： | 5 |
| 2 | Electromagnetic irradiation exposure and its bioindication–An overview显示文摘Man made electromagnetic irradiation and fields cover now the globe due to the recent extensive propagation of mobile telephony.The increased load affects animals and also plants.Especially birds have been studied.Humans are also sensitive.They are good bioindicators as epidemiological methods are available.Humans can also report symptoms which cannot be directly measured with presently available technologies.The nonionizing irradiation can as the ionizing one break the DNA,damage proteins,even increase the blood brain barrier permeability,disturb the night rest,cause fatigue and hormonal disturbances.An increase of the tumours of human head has been described in correlation with the long term mobile phone use and on that side more exposed.The regulations covering mobile telephony are already about two decades old and need re-evaluation.The multitude of irradiation and the interaction of the different wavelength exposures,i.e.,frequency sensitivity is poorly known at present.We should not forget the comparative studies of different species especially those which rely in their lives on electromagnetic orientation physiology.Some countries have issued warnings on the exposures of children.The producers of mobile technology have recently warned the users not to keep those devices in active stage in skin contact. | Osmo Hnninen Paavo Huttunen Reijo Ekman | 2011 | Journal of Environmental Sciences2011，23，9： | 3 |
| 3 | Everyday life information seeking: Approaching information seeking in the context of “way of life”显示文摘 | Reijo Savolainen | 1995 | Library and Information Science Research1995，，3： | 2 |
| 4 | Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene显示文摘 | ee TY alo P t al | | Nat Genet0，0，4： | 1 |
| 5 | Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats显示文摘 | Simo S. A. Miettinen Jarkko Jaatinen Alpo Pelttari Reijo Lappalainen Jukka M?nkk?nen Petri K. Venesmaa Heikki P. J. Kr?ger | 2009 | Journal of Orthopaedic Science2009，，4： | 1 |
| 6 | Human embryonic stem cell genes OCT4,NANOG,STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 7 | Male infertility,genetic analysis of the human Y chromosome and genetic analysis of DNA repair显示文摘 | Renee A Reijo P | 2002 | MCE2002，186，： | 1 |
| 8 | Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA- binding protein gene 显示文摘 | REIJO R LEE T Y SALO P | 1995 | Nature Genetics1995，10，4： | 1 |
| 9 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are ex pressed in both seminoma and breast carcinoma 显示文摘 | Ezeh U I Turek P J Reijo R A | 2005 | Cancer2005，104，10： | 1 |
| 10 | Considerations regarding the definition of a geochemical baseline of elements in the surficial materials in areas differing in basic geology显示文摘 | Reijo Salminen Virgilija Gregorauskien? | 2000 | Applied Geochemistry2000，，5： | 1 |
| 11 | Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-bingding protein gene显示文摘 | Lee TY Salo P | 1995 | Nat Gener1995，10，： | 1 |
| 12 | Male infertility ,genetic analysis of thehuman Y chromosome and genetic analysis of DNA repair显示文摘 | Mark SK Renee A Reijo P | 2002 | MCE2002，186，： | 1 |
| 13 | Treatment of Bleeding Pseudoaneurysms in Patients with Chronic Pancreatitis显示文摘 | Marianne Udd MD Ari K. Lepp?niemi MD PhD Siamak Bidel MD Pekka Keto MD PhD Wolf-Dieter Roth MD PhD Reijo K. Haapiainen MD PhD | 2007 | World Journal of Surgery2007，，3： | 1 |
| 14 | Human embryonic stem cells gene OCT4,NANOG,STELLAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 15 | Human embryonic stem cell genes OCT4,NANOG,STEILAR,and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 16 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma显示文摘 | Ezeh UI Turek PJ Reijo RA | 2005 | Cancer2005，104，10： | 1 |
| 17 | Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome显示文摘 | Tsuchiya K Reijo R Page DC | 1995 | Am J Hum Genet1995，57，： | 1 |
| 18 | Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene 显示文摘 | Reijo R Lee T Salo P | 1995 | Nat Genet1995，10，2： | 1 |
| 19 | Process-based view of product data management显示文摘 | Olli Pitkaenen Reijo Sulonen | 1996 | Computers in Industry1996，31，3： | 1 |
| 20 | Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 arc expressed in both seminoma and breast carcinoma 显示文摘 | Ezeh U I Turek P J Reijo R A | 2005 | Cancer2005，104，10： | 1 |
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