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| 1 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，37： | 2 |
| 2 | Fusiform aneurysm model in rabbit carotid artery 显示文摘 | Reinald N Fournier B Naveau A | 2010 | J Vase Res2010，47，： | 1 |
| 3 | Pathological aspects of lipid peroxidation显示文摘 | Anne Negre-Salvayre Nathalie Auge Victoria Ayala Huveyda Basaga Jordi Boada Rainer Brenke Sarah Chapple Guy Cohen Janos Feher Tilman Grune Gabriella Lengyel Giovanni E. Mann Reinald Pamplona Giuseppe Poli Manuel Portero-Otin Yael Riahi Robert Salvayre Shl | 2010 | Free Radical Research2010，，10： | 1 |
| 4 | Suppression of hepatitis B virus enhancer 1 and 2 by hepatitis C virus core protein显示文摘 | Christian G Schüttler Nicola Fiedler Katja Schmidt Reinald Repp Wolfram H Gerlich Stephan Schaefer | 2002 | Journal of Hepatology2002，，6： | 1 |
| 5 | Upper body movements in children with hemiplegic cerebral palsy walking with and without an ankle–foot orthosis显示文摘 | Katrin Schweizer Reinald Brunner Jacqueline Romkes | 2014 | Clinical Biomechanics2014，，： | 1 |
| 6 | A new set of nickelacyclic carboxylates ('nickelalactones') containing pyridine as supporting ligand:Synthesis,structures and application in C-C and C-S linkage reactions显示文摘 | Jens Langer Reinald Fischer Helmar G(o)rls | 2004 | Journal of Organometallic Chemistry2004，689，： | 1 |
| 7 | Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats显示文摘 | Tore Grimstad Bodil Bj? rndal Daniel Cacabelos Ole Gunnar Aasprong Emiel A.M. Janssen Roald Omdal Asbj? rn Svardal Trygve Hausken Pavol Bohov Manuel Portero-Otin Reinald Pamplona Rolf K. Berge | 2012 | Scandinavian Journal of Gastroenterology2012，，1： | 1 |
| 8 | Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain显示文摘 | Reinald Pamplonaa Manel Portero-Otin | 2004 | Exp Gerontol2004，39，： | 1 |
| 9 | A key step in the formation of acrylic acid from CO2 and ethylene:The transformation of a nickelalactone into a nickel-acrylate complex显示文摘 | Reinald Fischer Jens Langer Astrid Malassa | 2006 | Chem Commun2006，，： | 1 |
| 10 | Fusiform aneurysm model in rabbit carotid artery 显示文摘 | Reinald N Fournier B Naveau A | 2010 | J Vasc Res2010，47，： | 1 |
| 11 | Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals显示文摘 | Ian G. Cowell Rebecca Aucott Shantha K. Mahadevaiah Paul S. Burgoyne Neville Huskisson Silvia Bongiorni Giorgio Prantera Laura Fanti Sergio Pimpinelli Rong Wu David M. Gilbert Wei Shi Reinald Fundele Harris Morrison Peter Jeppesen Prim B. Singh | 2002 | Chromosoma2002，，1： | 1 |
| 12 | Fusiform aneurysmmodel in rabbit carotid artery 显示文摘 | Reinald N Fournier B Naveau A | 2010 | J Vase Res2010，47，1： | 1 |
| 13 | Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress显示文摘 | Alba Naudi Mariona Jove Victoria Ayala Anna Cassanye Jose Serrano Hugo Gonzalo Jordi Boada Joan Prat Manuel Portero-Otin Reinald Pamplona Robert A. Harris | 2012 | Experimental Diabetes Research2012，，： | 1 |
| 14 | Cytokinin Activity Induced by Thidiazuron显示文摘 | John Calvin Thomas Frank Reinald Katteran | 1986 | Plant Physiol1986，，81： | 1 |
| 15 | Gingival fibroblasts inhibit MMP-I and MMP-3 activities in an ex-vivo artery model显示文摘 | Naveau A Reinald N Fournier B etal | 2007 | Cormeet Tissue Res2007，48，6： | 1 |
| 16 | Cytokinin activity induced by thidiazuron显示文摘 | John Calvin Thomas Frank Reinald Katterman | 1986 | Plant Physiology1986，81，： | 1 |
| 17 | A new set of nickelacyclic carboxylates ('nickelalactones') containing pyridine as supporting ligand: synthesis, structures and application in C-C- and C-S- linkage reactions 显示文摘 | Jens Langer Reinald Fischer Helmar G6rls | 2004 | Journal of Organometallic Chemistry2004，689，： | 1 |
| 18 | Lack of correlation between placenta and offspring size in mouse interspecific crosses显示文摘 | H. Kurz Ulrich Zechner Annie Orth Reinald Fundele | 1999 | Anatomy and Embryology1999，，3： | 1 |
| 19 | Cell senescence,loss of splicing,and lipid metabolism in TDP-43-related neurodegenerative processes显示文摘In recent work,we have shown that cell senescence of mouse fibroblasts in vitro associates with a build-up of cryptic exons in selected mRNAs,whose level is usually controlled by the activity of TAR DNA binding protein of 43 kDa(Tdp-43)(Torres et al.,2022).In vivo,we also found traits of cell senescence in the motor neuron disease model achieved by overexpressing SOD-G93A,the SOD1 gene(harboring a single amino acid substitution of glycine to alanine at codon 93). | Pascual Torres Reinald Pamplona Manuel Portero-Otin | 2023 | Neural Regeneration Research2023，18，8： | 0 |
| 20 | 基于LC-Q-TOF的多组织代谢组学:一种确认受富含多元酚食物影响小鼠新的代谢通路的探索工具显示文摘现在有关膳食对机体影响的代谢组学研究仅仅是研究膳食对血样和尿样的影响,而忽略了其他生物样本,例如盲肠内容物,就等于遗漏了消化系统的作用和忽略了肠道微生物菌群在代谢中的重要作用和其在生物利用率方面的影响。许多研究已经证明多组织样本代谢组学在评估营养物质在机体内的代谢影响方面的重要性。然而这些研究都是以核磁共振技术为分析手段的,由于核磁共振技术的低灵敏度,限制了可检测代谢产物的数量。 | Mariona Jove Jose C.E.Serrano Nadia Ortega Victoria Ayala Neus Angles Jordi Reguant Jose R.Morello Maria Paz Romero Maria Jose Motilva Joan Prat Reinald Pamplona Manuel Portero-Otin 王茂清 | 2012 | 营养健康新观察2012，0，1： | 0 |
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