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| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Constructing polycompetitor cDNAs for quantitative PCR显示文摘 | Reiner S L S Zheng and D B Corry | 1993 | Immunol Methods1993，165，： | 1 |
| 3 | Redifferentiation therapy with retinoids: therapeutic option for advanced follicular and papillary carcinoma显示文摘 | Koehrle J Reiners C | 1998 | Wold J Surg1998，22，： | 1 |
| 4 | Enhancement of response times to bi - and tri - modal sensory stimuli during active movements显示文摘 | Hecht D Reiner M Kami A | 2008 | Exp Brain Res2008，185，： | 1 |
| 5 | The neural substrate for the pupillary light reflex in the pigeon (Columba livia)显示文摘 | Gamlin P D Reiner A Erichsen J T | 1984 | J Comp Neurol1984，226，： | 1 |
| 6 | Parenting Sensitivity, Parental Depression and Child Health: The Mediational Retie of Parental Self- Efficacy显示文摘 | Teti D O'Connell M Reiner C | 1999 | Early Development and Parenting1999，5，4： | 1 |
| 7 | Apoptosis and autophagy after mitochondrial or endoplasmic reticulum photodamage 显示文摘 | Kessel D Reiners JJ Jr | 2007 | Pbotoshem Photobiol2007，83，5： | 1 |
| 8 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 9 | Mechanical properties of SiO2 and Si3N4 coatings: a BAM/ NIST co-operative project 显示文摘 | BECK U SMITH D T REINERS G | 1998 | Thin Solid Films1998，332，12： | 1 |
| 10 | Differential loss of striatal projection neurons in Huntington's disease 显示文摘 | Reiner A Albin R L Anderson K D | 1988 | Proc Natl Aead Sei USA1988，85，15： | 1 |
| 11 | Plant diversity ina chronosequence at Glacier Bay, Alaska显示文摘 | Reiners W A Worley I A Lawrence D B | 1971 | Ecology1971，52，1： | 1 |
| 12 | Determination of N-nitrosodime-thylamine by isotope dilution,high-resolution mass spectrometry显示文摘 | TAGUCHI V Y JENKINS S W D WANG D T PALMENTIER J P F P REINER E J | 1994 | Can J Appl Spectrosc1994，39，3： | 1 |
| 13 | Redifferentiation therapy with retinoids: therapeutic option for advanced follicular and papillary thyroid carcinoma显示文摘 | Simon D Koehrle J Reiners C | 1998 | World J Surg1998，22，： | 1 |
| 14 | 9-cis retinoic Ac- id protects against methamphetamine-induced neurotoxic- ity in nigrostriatal dopamine neurons 显示文摘 | REINER D J YU S J SHEN H | 2014 | Neurotox Res2014，25，3： | 1 |
| 15 | Ovarian toxicity from sirolimus显示文摘 | Braun M Young J Reiner CS Poster D Wüthrich RP Serra AL | 2012 | N Engl J Med2012，366，11： | 1 |
| 16 | Long-term health benefits of physical activity-a systematic review of longitudinal studies 显示文摘 | REINER M NIERMANN C JEKAUC D | 2013 | BMC Public Health2013，，13： | 1 |
| 17 | Saccharomyces cerevisiae, a model to study sterol uptake and transport in eukaryotes显示文摘 | REINER S MICOLOD D SCHNEITER R | 2005 | Biochemical Society Transactions2005，33，5： | 1 |
| 18 | Tile drivers of Chinese CO2 emissions from 1980 to 2030 显示文摘 | Guan D Hubacek K Weber C L Peters G P Reiner D M | 2008 | Global Environmental Change2008，18，4： | 1 |
| 19 | Rw differentiation therapy with yetinoids:therapeutic option for advanced follicular and papillary thyroid carcinoma显示文摘 | Simon D Kcehrle J Reiners C | 1998 | World J Sur1998，22，6： | 1 |
| 20 | Oxidation of arsenate (Ⅲ) with manganese oxides in water treatment显示文摘 | WOLFGANG D REINER S MARTIN J | 1995 | Water Research1995，29，1： | 1 |
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