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| 1 | Efficacy, risk factors and complications of endoscopic polypectomy: Ten year experience at a single center显示文摘AIM: To examine the efficacy and complications of colonoscopic resection of colorectal polypoid lesions. METHODS: We retrospectively reviewed 1354 polypectomies performed on 1038 patients over a ten- year period. One hundred and sixty of these were performed for large polyps, those measuring ≥ 20 mm. Size, shape, location, histology, the technique of polypectomy used, complications, drugs assumption and associated intestinal or extra intestinal diseases were analyzed. For statistical analysis, the Pearson χ2 test, NPC test and a Binary Logistic Regression were used. RESULTS: The mean patient age was 65.9 ± 12.4 years, with 671 men and 367 women. The mean size of polyps removed was 9.45 ± 9.56 mm while the size of large polyps was 31.5 ± 10.8 mm. There were 388 pedunculated and 966 sessile polyps and the most common location was the sigmoid colon (41.3%). The most frequent histology was tubular adenoma (55.9%) while for the large polyps was villous (92/160 -57.5%). Coexistent malignancy was observed in 28 polyps (2.1%) and of these, 20 were large polyps. There were 17 procedural bleeding (1.3%) and one perforation. The statistical analysis showed that cancer is correlated to polyp size (P < 0.0001); sessile shape (P < 0.0001) and bleeding are correlated to cardiac disease (P = 0.034), tubular adenoma (P = 0.016) and polyp size.CONCLUSION: The endoscopic resection is a simple and safe procedure for removing colon rectal neoplastic lesions and should be considered the treatment of choice for large colorectal polyps. The polyp size is an important risk factor for malignancy and for bleeding. | Pierluigi Consolo Carmelo Luigiano Giuseppe Strangio Maria Grazia Scaffidi Giuseppa Giacobbe Giovanna Di Giuseppe Agata Zirilli Luigi Familiari | 2008 | World Journal of Gastroenterology2008，14，15： | 33 |
| 2 | Virtual reality simulation in endoscopy training:Current evidence and future directions显示文摘Virtual reality simulation is becoming the standard when beginning endoscopic training. It offers various benefits including learning in a low-stakes environment, improvement of patient safety and optimization of valuable endoscopy time. This is a review of the evidence surrounding virtual reality simulation and its efficacy in teaching endoscopic techniques. There have been 21 randomized controlled trials(RCTs) that have investigated virtual reality simulation as a teaching tool in endoscopy. 10 RCTs studied virtual reality in colonoscopy, 3 in flexible sigmoidoscopy, 5 in esophagogastroduodenoscopy, and 3 in endoscopic retrograde cholangiopancreatography. RCTs reported many outcomes including distance advanced in colonoscopy, comprehensive assessment of technical and non-technical skills, and patient comfort. Generally, these RCTs reveal that trainees with virtual reality simulation based learning improve in all of these areas in the beginning of the learning process. Virtual reality simulation was not effective as a replacement of conventional teaching methods. Additionally, feedback was shown to be an essential part of the learning process. Overall, virtual reality endoscopic simulation is emerging as a necessary augment to conventional learning given the ever increasing importance of patient safety and increasingly valuable endoscopy time; although work is still needed to study the nuances surrounding its integration into curriculum. | Tahrin Mahmood Michael Anthony Scaffidi Rishad Khan Samir ChANDra Grover | 2018 | World Journal of Gastroenterology2018，24，48： | 10 |
| 3 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 4 | Karrikin and Cyanohydrin Smoke Signals Provide Clues to New Endogenous Plant Signaling Compounds显示文摘表明混合物的二种新类型由于他们刺激种子萌芽的能力在野火烟被发现了。第一发现了是 karrikins,它与植物荷尔蒙的 strigolactone 类分享某结构的类似,并且两个都通过普通 F 盒子蛋白质发信号。然而, karrikins 和 strigolactones 通过不那样不同的发信号的小径操作,各由特定的 / hydrolase 蛋白质区分了。基因分析建议植物包含通过 karrikin 小径明确地发信号的内长的混合物。在烟发现的另外的活跃混合物是在水解作用之上释放刺激萌芽的氰化物的氰醇。氰醇在植物广泛地发生并且在内长的氰化物发信号对另外的有机体,而是一个另外的角色在防卫有一个角色现在应该也被考虑。 | Gavin R. Flematti Mark T. Waters Adrian Scaffidi David J. Merritt Emilio L. Ghisalberti' Kingsley W.Dixon Steven M. Smith | 2013 | Molecular Plant2013，6，1： | 3 |
| 5 | Simulation in endoscopy:Practical educational strategies to improve learning显示文摘In gastrointestinal endoscopy, simulation-based training can help endoscopists acquire new skills and accelerate the learning curve. Simulation creates an ideal environment for trainees, where they can practice specific skills, perform cases at their own pace, and make mistakes with no risk to patients. Educators also benefit from the use of simulators, as they can structure training according to learner needs and focus solely on the trainee. Not all simulation-based training,however, is effective. To maximize benefits from this instructional modality,educators must be conscious of learners' needs, the potential benefits of training,and associated costs. Simulation should be integrated into training in a manner that is grounded in educational theory and empirical data. In this review, we focus on four best practices in simulation-based education: deliberate practice with mastery learning, feedback and debriefing, contextual learning, and innovative educational strategies. For each topic, we provide definitions,supporting evidence, and practical tips for implementation. | Rishad Khan Michael A Scaffidi Samir C Grover Nikko Gimpaya Catharine M Walsh | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，3： | 3 |
| 6 | Depression, Anxiety and Anger in Subtypes of Irritable Bowel Syndrome Patients显示文摘 | Maria Rosaria A. Muscatello Antonio Bruno Gianluca Pandolfo Umberto Micò Simona Stilo Mariagrazia Scaffidi Pierluigi Consolo Andrea Tortora Socrate Pallio Giuseppa Giacobbe Luigi Familiari Rocco Zoccali | 2010 | Journal of Clinical Psychology in Medical Settings2010，，1： | 2 |
| 7 | Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion显示文摘 | Bonaldi T Talamo F Scaffidi P | | 0，，20： | 1 |
| 8 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation显示文摘 | Scaffidi P Misteli T Bianchi ME | 2002 | Nature2002，418，6894： | 1 |
| 9 | Two CD95 (APO21/Fas) signaling pathways显示文摘 | Scaffidi C Fulda S Srinivasan A | 1998 | EMBO J1998，17，： | 1 |
| 10 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation显示文摘 | Scaffidi Pet | 2002 | Nature2002，418，： | 1 |
| 11 | Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion显示文摘 | Bonaldi T Talamo F Scaffidi P | 2003 | EMBO J2003，22，20： | 1 |
| 12 | New EMBO members'review: the double life of HMGB 1 chromatin protein: architectural factor and extraceUular signal 显示文摘 | Muller S Scaffidi P Degryse B | 2001 | EMBO J2001，20，16： | 1 |
| 13 | Monocytic cells hypemcetylate chmmatin protein HMGB1 to redirect it towards secretion显示文摘 | Bonaldi T Talamo F Scaffidi P | 2003 | EMBOJ2003，22，20： | 1 |
| 14 | The high mobilitygroup(HMG) boxes of the nuclear protein HMG1 inducechemotaxis and cytoskeleton reorganization in rat smooth musclecells显示文摘 | Degryse B Bonaldi T Scaffidi P | 2001 | J Cell Biol2001，152，6： | 1 |
| 15 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 16 | Emission enhancement mechanisms in dual-pulse LIBS 显示文摘 | SCAFFIDI J M ANGEL S CREMERS D A | 2006 | Analytical Chemistry2006，78，1： | 1 |
| 17 | New EMBO members′ review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal显示文摘 | Muller S Scaffidi P Degryse B | 2001 | EMBO J2001，20，16： | 1 |
| 18 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation显示文摘 | Scaffidi P Misteli T Bianchi M E | 2002 | Nature2002，418，： | 1 |
| 19 | The high mobility group (HMG) boxes of the nuclear protein HMGl induce chemotaxis and eytoskeleton reorganization in rat smooth muscle cells显示文摘 | Degryse B Bonaldi T Scaffidi P | 2001 | J Cell Biol2001，152，6： | 1 |
| 20 | Magnetic resonance cholangio-pancreatography versus endoscopic retrograde cholangio-pancreatography in the diagnosis of comimon bile duct stones:a prospective comparative study显示文摘 | Scaffidi MG Luigiano C Consolo P | 2009 | Minerva Med2009，100，5： | 1 |
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