| 1 | Changes in circulating inflammatory cells and the relationship to secondary brain injury in patients with craniocerebral injury显示文摘BACKGROUND:Recent studies have indicated that reactive encephalitis plays an important role in secondary tissue damage after craniocerebral injury. OBJECTIVE: To observe changes in white blood cells (WBC) and polymorphonuclear neutrophils (PMN) in peripheral blood, and to determine their role in secondary brain insult in patients with craniocerebral injury. DESIGN, TIME AND SETTING: A case-control study at the Department of Neurosurgery of the Affiliated Hospital North Sichuan University of Medical Sciences between August 2007 and May 2008. PARTICIPANTS: Sixty-three patients, admitted within 24 hours after craniocerebral injury and who received no surgery, were included in the study. The cohort consisted of 41 males and 22 females, aged 9–72 years, with an average age of 42 years. Ten healthy volunteers, selected from the Department of Neurosurgery, were designated as the control group. METHODS: WBC and PMN from the peripheral blood were measured 0, 24, 48, 72, and 168 hours after admission to hospital. The Glasgow coma scale, area of cerebral hemorrhage, and degree of brain edema were simultaneously determined. The Glasgow outcome scale was evaluated six months after injury. The relationship between changes in WBC and PMN were analyzed. Sixty-three patients were divided into 0, 24, 48, 72, and 168 hours groups, with admission time to hospital as the determining factor. As controls, WBC and PMN of peripheral blood were also detected in 10 healthy volunteers. MAIN OUTCOME MEASURES: The main outcome measures were WBC and PMN counts in the peripheral blood at 0, 24, 48, 72, and 168 hours after admission to hospital, the mutual relationship between GCS, WBC and PMN, and changes in brain hemorrhage volume and edema size. RESULTS: WBC peaked at 24 hours after injury, and PMN peaked at 48 hours after injury (P < 0.01). These measures negatively correlated to the Glasgow coma scale (r = -0.657, -0.541, respectively, P < 0.05). In patients with Glasgow coma sale < 8, WBC and PMN were significantly higher than in the patients with GCS ≥ 8 (P < 0.05). Cerebral hemorrhage reached a peak at 24 hours after injury, and the degree of brain edema was maximal at 168 hours after injury. WBC and PMN counts were positively correlated to cerebral hemorrhage volume and brain edema size (P < 0.05). CONCLUSION: WBC and PMN counts significantly increased after craniocerebral injury and exhibited a correlation with the GCS score, volume of hemorrhage and edema, and Glasgow outcome scale. | Xiaoping Tang Tao Zhang Yuanchuan Wang Hua Peng Ling Feng Jian Qi Wenguo Tang Zhangyang Gou Dingyong Yu Renguo Luo | 2008 | Neural Regeneration Research2008，3，8： | 1 |
| 2 | Changes in platelet parameters and secondary brain injury in acute craniocerebral trauma显示文摘Changes in platelet parameters are important in secondary brain injury in acute craniocerebral trauma.We selected 163 patients with craniocerebral trauma who were admitted within 24 hours with nonoperative therapy.Platelet parameters of 40 healthy subjects served as controls.Platelet number was decreased,while mean platelet volume and platelet distribution width values were increased,at 1 and 3 days after injury.Platelet number was lower and mean platelet volume and platelet distribution width were larger in patients with traumatic cerebral infarction and those in Glasgow Coma Scale score < 8 group.Platelet number was negatively correlated to volume of cerebral edema,but positively correlated to Glasgow Outcome Scale score.These data indicate that changes in platelet parameters may be utilized to indicate the state of central nervous system injury and patient prognosis. | Xiaoping Tang Chao You Hua Peng Tao Zhang Wenguo Tang Jian Qi Renguo Luo Yuanchuan Wang Ling Feng Zhangyang Gou Junwei Duan Shun Li | 2011 | Neural Regeneration Research2011，6，20： | 0 |
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