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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001显示文摘AIM: To evaluate how proximal colon polyps interpreted as hyperplastic polyps in 2001 would be interpreted by expert pathologists in 2007. METHODS: Forty consecutive proximal colon polyps ≥ 5 mm in size, removed in 2001, and originally interpreted as hyperplastic polyps by general pathologists at Indiana University, were reviewed in 2007 by 3 GI pathologists. RESULTS: The gastrointestinal (GI) pathologists interpreted 85%, 43% and 30% of the polyps as sessile serrated polyps (sessile serrated adenomas). The overall Kappa was 0.16. When diagnoses were compared in pairs, Kappa values were 0.38 and 0.25 (fair agreement) and 0.14 (slight agreement). CONCLUSION: Many polyps interpreted as hyperplastic in 2001 were considered sessile serrated lesions by GI pathologists in 2007, but there is substantial inter-observer variation amongst GI pathologists. | Omer Khalid Sofyan Radaideh Oscar W Cummings Michael J O'Brien John R Goldblum Douglas K Rex | 2009 | World Journal of Gastroenterology2009，15，30： | 3 |
| 4 | Environmental influences on regional deep-sea species diversity显示文摘 | Levin L A Etter R J Rex M A | 2001 | Annual Review of Ecology and Systematics2001，32，： | 1 |
| 5 | The rate of progress and destructiveness of canker stain of planetrees 显示文摘 | WALTER J M Rex E G Schreiber R | 1952 | Phytopathology1952，42，： | 1 |
| 6 | The Aer-O-Scope: Proof of the concept of a pneumatic, skill-independent, self-propelling, self-navigating colonoscope in a pig model显示文摘 | Pfeffer J Grinshpon R Rex D | 2006 | Endoscopy2006，38，2： | 1 |
| 7 | Combating antimicrobial resistance: policy recommendations to save lives 显示文摘 | Infectious Diseases Society of America (IDSA) Spellberg B Blaser M Guidos RJ Boucher HW Bradley JS Eisenstein BI Gerding D Lynfield R Relier LB Rex J Schwartz D Septimus E Tenover FC Gilbert DN | 2011 | Clin Infect Dis2011，52，5： | 1 |
| 8 | Oxygen isotope abundance in quartz from Pacific pelagic sediments显示文摘 | CLAYTON R N REX R W SYERS J K | 1972 | Journal of Geophysical Research1972，77，21： | 1 |
| 9 | Cloning and characterization of a Candida albicans maltase gene involved in sucrose utilization显示文摘 | Antotia G Peter R W Rex J H | 1992 | Journal of Bacteriology1992，174，： | 1 |
| 10 | The trailing end point phenotype in antifungal susceptibility testing is PH-dependent 显示文摘 | MARR K A RUSTAD T R REX J H | 1999 | Antimicrob Agents Chemother1999，43，： | 1 |
| 11 | Quartz Isolation from Rocks,Sediments,and Soils for Determination of Oxygen Isotopic Composition显示文摘 | Syers J K Chapman S L Rex R W | 1986 | Geochimica et Cosmochimica Acta1986，32，： | 1 |
| 12 | Oxygen isotope abundance in quartz from Pacific pelagic sediments显示文摘 | Clayton R N Rex R W Syers J K | | 0，，21： | 1 |
| 13 | Analysis of endocrine disruptors, pharmaceuticals, and personal care products in water using liquid chromatography/tandem mass spectrometry 显示文摘 | Vanderford B J Pearson R A Rexing D J | 2003 | Anal Chem2003，75，22： | 1 |
| 14 | Serrated lesions of the colorectum: re-view and recommendations from an expert panel 显示文摘 | Rex D K Ahnen D J Baron J A Batts K P Burke C A Burt R W | 2012 | Am J Gastroenterol?2012，107，： | 1 |
| 15 | Quartz isolation from rocks, sediments, and soils for determination of oxygen isotopic composition 显示文摘 | Syers J K Chapman S L Jackson M L Rex R W Clayton R N | 1968 | Geochimica et Cosmochimica Acta1968，32，9： | 1 |
| 16 | Detection of amphotericin B-resistant Candida isolates in a broth-based system显示文摘 | Rex J H Cooper C R Jr Merz W G | 1995 | Antimicrob Agents Chemother1995，39，4： | 1 |
| 17 | Soil carbon dioxide and methane fluxes from long-term tillage systems in continuous corn and corn-soybean rotations显示文摘 | Rex A O Tony J V Doug R | 2007 | Soil & Tillage Research2007，95，12： | 1 |
| 18 | Heat stress and seasonal effects on reproduction in the dairy cow a review显示文摘 | Fabio D R Rex J S | 2003 | Theriogenology2003，60，： | 1 |
| 19 | Oxygen isotope abundance in quartz from Pacific pelagic sediments显示文摘 | CLAYTON R N REX R W SYERS J K | 1972 | Journal of Geophysical Research1972，77，21： | 1 |
| 20 | Oxygen isotope abundance in quartz from Pacific pelagic sediments显示文摘 | Clayton R N Rex R W Syers J K | 1972 | Journal of GeoPhysical Research1972，77，21： | 1 |
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