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| 1 | Bacterial biota in reflux esophagitis and Barrett's esophagus显示文摘AIM: To identify the bacterial flora in conditions such as Barrett's esophagus and reflux esophagitis to determine if they are similar to normal esophageal flora.METHODS: Using broad-range 16S rDNA PCR,esophageal biopsies were examined from 24 patients [9with normal esophageal mucosa, 12 with gastroesophageal reflux disease (GERD), and 3 with Barrett's esophagus].Two separate broad-range PCR reactions were performed for each patient, and the resulting products were cloned.In one patient with Barrett's esophagus, g9 PCR clones were analyzed.RESULTS: Two separate clones were recovered from each patient (total = 48), representing 24 different species, with 14 species homologous to known bacteria,5 homologous to unidentified bacteria, and 5 were not homologous (<97% identity) to any known bacterial 16S rDNA sequences. Seventeen species were found in the reflux esophagitis patients, 5 in the Barrett's esophagus patients, and 10 in normal esophagus patients.Further analysis concentrating on a single biopsy from an individual with Barrett's esophagus revealed the presence of 21. distinct bacterial species. Members of four phyla were represented, including Bacteroidetes,Firmicutes, Proteobacteria, and Actinobacteria.Microscopic examination of each biopsy demonstrated bacteria in intimate association with the distal esophageal epithelium, suggesting that the presence of these bacteria is not transitory.CONCLUSION: These findings provide evidence for a complex, residential bacterial population in esophageal reflux-related disorders. While much of this biota is present in the normal esophagus, more detailed comparisons may help identify potential disease associations. | Zhiheng Pei Liying Yang Richard M Peek Jr Steven M Levine David T Pride Martin J Blaser | 2005 | World Journal of Gastroenterology2005，11，46： | 11 |
| 2 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 3 | Helicobacter pylori and gastrointestinal adenocarcinomas显示文摘 | Peek R M Jr blaser M J | 2002 | Nat Res Cancer2002，2，1： | 1 |
| 4 | The interaction between caveolin-t and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk 显示文摘 | Arpaia E Blaser H Quintela-Fandino M | 2012 | Oncogene2012，31，7： | 1 |
| 5 | Beta-galactoside- binding protein secreted by activated T cells inhibits antigen- induced proliferation of T cells显示文摘 | Blaser C Kaufinann M Muller C | 1998 | Eur J Immunnl1998，25，8： | 1 |
| 6 | Industrial-strength security for ZigBee: the case forpublic-key cryptography显示文摘 | Blaser M | 2005 | Embedded Computing Design2005，3，3： | 1 |
| 7 | Enantioselective catalysis in fine chemicals products显示文摘 | Blaser H U Spindlder F Studer M | 2001 | Applied Catalysis2001，，： | 1 |
| 8 | Recombinant expression and antigenic properties of a 32-kilodalton extracellular alkaline protease, representing a possible virulence factor from Aspergillus fumigatus显示文摘 | Menz G Blaser R | 1994 | Infect Immun1994，62，6： | 1 |
| 9 | Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori显示文摘 | Céu Figueiredo Wim G.V Quint Ricardo Sanna Erwin Sablon John P Donahue Qing Xu Geraldine G Miller Richard M Peek Martin J Blaser Leen-Jan van Doorn | 2000 | Gene2000，，1： | 1 |
| 10 | 4-hydroxyphenylacetate decarboxylases: properties of a novel subclass of glycyl radical enzyme systems显示文摘 | Yu L Blaser M Andre/P I | 2006 | Biochemistry2006，45，31： | 1 |
| 11 | Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis显示文摘 | Lund E Sheets M D Blaser I S | 2011 | Genes&Development2011，25，11： | 1 |
| 12 | Proteases and their inhibitors are indicative in gestational disease 显示文摘 | KOLBEN M LOPENS A BLASER J | 1996 | Eur J Obstet Gyneeol Reprod Biol1996，68，12： | 1 |
| 13 | T regulatory cells in allergy : novelconcepts in the pathogenesis, prevention, and treatment of allergicdiseases显示文摘 | Akdis M Blaser K Akdis CA | 2005 | J Allergy Clin Immunol2005，116，5： | 1 |
| 14 | Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey显示文摘 | Cho I Blaser M J Francois F | 2005 | Am J Epidemiol2005，162，6： | 1 |
| 15 | Discovery research:the scientific challenge of finding new antibiotics显示文摘 | Livermore D M Blaser M Carrs O | 2011 | Journal of Antimicrobial Chemotherapy2011，66，9： | 1 |
| 16 | Helicobacter pylori and gastrointestinal adenocarcinomas显示文摘 | Peek R M Jr Blaser M J | 2002 | Nat Rev Cancer2002，2，1： | 1 |
| 17 | Differential Diagaosis of Intracranial Cystic Lesions at Head US:Correlation with CT and MR Imaging显示文摘 | Epelman M Dancman A Blaser SI | 2006 | RadioGraphics2006，26，1： | 1 |
| 18 | Helicobacter pylori and the pathogenesis of gastroduodenal inflammation 显示文摘 | Blaser M J | 1990 | Journal of Infectious Diseases1990，161，4： | 1 |
| 19 | 查看详情显示文摘 | Herold H Indolese A.F Studer M Jalett H.P Siegrist U. Blaser H | | 0，，： | 1 |
| 20 | T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic disease 显示文摘 | Akdis M Blaser K Akdis CA | 2005 | J Allergy Clin Immunol2005，116，： | 1 |
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