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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Supercritical fluid extraction of lipids from spent coffee grounds显示文摘 | Ricardo M C Joao F Gomes da Silva M D R | 2009 | Journal of Supercritical Fluids2009，51，： | 1 |
| 3 | Mathematical modeling and experimental results of a sandwich-type amperometric biosensor 显示文摘 | RICARDO R M BARUZZI A M GARAY F | 2012 | Sensors and Actuators B - Chemical2012，162，1： | 1 |
| 4 | Young age is an independent prognostic factor for survival of sporadic renal cell carcinoma显示文摘 | Ricardo F S Charles J R Lydia T M | 2004 | J Urol2004，171，61： | 1 |
| 5 | Breast cancer stem eell mark- ers CD44, CD24 and ALDH1 :expression distribution within intrinsic molecular subtype显示文摘 | Ricardo S Vieira A F Gerhard R | 2011 | J Clin Pathol2011，64，11： | 1 |
| 6 | Cadmium stress in sugar cane callus cultures: Effect on antioxidant enzymes显示文摘 | Ricardo F F Renato R F Guilherme J G P | 2002 | Plant Cell Tissue and Organ Culture2002，71，： | 1 |
| 7 | Breast cancer stem cell markers CD44, CD24 and ALDHI: expression distribution within intrinsic molecular subtype显示文摘 | Ricardo S Vieira A F Gerhard R | 2011 | J Clin Pathol2011，64，11： | 1 |
| 8 | Protein degradation in C3 and C4 plants with particular reference to ribulose bisphosphate carboxylase and glycolate oxidase显示文摘 | MARIA G E RICARDO B F ARTUR R T | 1998 | Journal of Experimental Botany1998，49，： | 1 |
| 9 | Synthesis and antioxidant activity evaluation of new 7-aryl or 7- heteroarylamino-2,3-dimethylbenzo thiophenes ob- tained by Buchwald - Hartwig C - N cross-coupling 显示文摘 | Maria J R Isabel C F Ricardo C | 2007 | Bioorh Med Chem2007，15，： | 1 |
| 10 | Focussed microwave-assisted sample preparation:Total phenol determination in petroleum refinery effluents by flow injection spectrophotometry显示文摘 | Quaresmaa M C B Cassellab R J Carvalhoc M F B Ricardo E Santelli R E | 2004 | Microchemical Journal2004，78，： | 1 |
| 11 | Eversion thromboendovenectomy in organized portal vein thrombosis during liver transplantation显示文摘 | Ricardo R Juan (A)F Quiteria H | 2004 | Clin Transplant2004，18，1： | 1 |
| 12 | Cicadapeptins I and II:New Aib-Containing Peptides from the Entomopathogenic Fungus Cordyceps heteropoda显示文摘 | Stuart B K Ricardo F R Melissa M W | 2005 | Natural Product Reports2005，68，： | 1 |
| 13 | Active control of broad structural vibration using the LMS adaptive algorithm显示文摘 | Jeffrey S V Ricardo A B Chris R F | 1993 | Journal of Sound and Vibration1993，166，2： | 1 |
| 14 | Tumor hypoxia: the role of HIF 显示文摘 | Avelino F Ricardo R Rui M | 2009 | Actas Urol Esp2009，3，9： | 1 |
| 15 | The bactericidal activities of HMR 3004 HMR-3647 and erythromycin against gram-positive bacillin and development of resistance显示文摘 | Ricardo F R Raquel C | 1999 | Antimicrob Agents Chemother1999，43，2： | 1 |
| 16 | Adaptive synchronization of high-order chaotic systems:a feedback with low-order parametrization显示文摘 | RICARDO F JOSE A R GUILLERMO F A | 2000 | PHYSICA D2000，139，： | 1 |
| 17 | Synchronization of a class of strictly different chaotic oscillators显示文摘 | RICARDO F JOSE A R | 1997 | Physics Letters A1997，236，4： | 1 |
| 18 | Apoptosis is a major pathway responsible for the resolution of type Ⅱ pneumocyt in acute lung injury显示文摘 | Ricardo H Bardales R Bobert F | 1996 | American J Pathol1996，149，3： | 1 |
| 19 | Implementation of a molecular system for traceability of beef based on micro satellite markers显示文摘 | Ricardo F D Boris S D Renato C R | 2008 | Chilean Journal of Agricultural Research2008，68，4： | 1 |
| 20 | Objecdted-Oriented Finite Eelement Analysis显示文摘 | Bruce W R F Ricardo O F Siegfried F S | 1990 | Computers & Structers1990，34，3： | 1 |
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