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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power显示文摘 | Isabel C F R Ferreira Maria-Jo(a)o R P Queiroz Miguel Vilas-Boas | | 0，，： | 1 |
| 3 | 显示文摘 | Karim F Isabelle C Jean PP | 1998 | Cancer1998，82，6： | 1 |
| 4 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 5 | Changes in endocarmabinoid transmission in the basal ganglia in a rat model of Huntington's disease显示文摘 | Isabel L Filomena F Maribel C | 2001 | Neuroreport2001，12，10： | 1 |
| 6 | Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory en-sheathing glia 显示文摘 | RAMON-CUETO ISABEL C FERNANDO F | 2000 | Neuron2000，25，： | 1 |
| 7 | Effects of the combination of hydrophobic polypeptides,iso-αacids,and malto-oligosaccharides on beer foam stability显示文摘 | Isabel M P L V O F Erreira Kaa Tia Jorge Luciana C Nogueira | 2005 | J Agric Food Chem2005，53，12： | 1 |
| 8 | Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal:Individual cap and stipe activity显示文摘 | Isabel C F R Ferreira Paula Baptista Miguel Vilas-Boas | 2007 | Food chemistry2007，100，： | 1 |
| 9 | Bacterial cel- lulose membranes as transdermal delivery systems for di- clofenac: In vitro dissolution and permeation studies 显示文摘 | Nuno H C S S Artur F R Isabel F A | 2014 | Carbohydr Polym2014，106，： | 1 |
| 10 | Modelling 02 and CO2 Exchange for Development of Perforation-medi- ated Atmosphere Packaging显示文摘 | SUSANA C F FERNANDA A R ISABEL B M | 2000 | Journal of Food Engineer- ing2000，43，： | 1 |
| 11 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 12 | Vibrational spectroscopy:a clinical tool for cancer diagnostics显示文摘 | KENDALL C ISABELLE M BAZANT-HEGEMARK F | 2009 | Analyst2009，134，6： | 1 |
| 13 | Synthesis and antioxidant activity evaluation of new 7-aryl or 7- heteroarylamino-2,3-dimethylbenzo thiophenes ob- tained by Buchwald - Hartwig C - N cross-coupling 显示文摘 | Maria J R Isabel C F Ricardo C | 2007 | Bioorh Med Chem2007，15，： | 1 |
| 14 | Calcium and magnesium binding to human centrin 3 and interaction with target peptides 显示文摘 | Jos A C Fabiana T Isabelle D Claudia F Yves B Patricia D Constantin T C | 2005 | Biochemistry2005，44，： | 1 |
| 15 | Antioxidant activities of the extracts from chestnut flower, leaf, skins and fruit显示文摘 | JOAO C M BARREIRA ISABEL C F R FERREIRA M BEATRIZ P P OLIVEIRA | 2008 | FoodChemistry2008，107，： | 1 |
| 16 | Phenolic acids determination by HPLC-DAD-ESI/MS in sixteen different portuguese wild mushrooms species 显示文摘 | Lillian Barros Montserrat Duet]as Isabel C F R Ferreira eta/ | 2009 | Food & Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association2009，47，6： | 1 |
| 17 | Nutritional, fatty acid and triacylglycerol profiles of Castanea sativa Mill, cultivars: a compositional and chemometric approach显示文摘 | JOAO C M SUSANA C ISABEL C F R | 2009 | Journal of Agricultural and Food Chemistry2009，57，7： | 1 |
| 18 | Dormancy cycling in Arabidopsis seeds is controlled by seasonally distinct hormone signa- ling pathways显示文摘 | Steven F Isabel D S Heather C | 2011 | Proceedings of the National Academy of Sciences2011，108，20： | 1 |
| 19 | Antioxidant activities of the extracts from chestnut flower, leaf, skins and fruit显示文摘 | BARREIRA C ISABEL C F BEATRIZ P O | 2008 | Food Chemistry2008，107，： | 1 |
| 20 | Direct solid sample analysis with graphite furnace atomic absorption spectrometry-A fast and reliable screening procedure for the determination of inorganic arsenic in fish and seafood显示文摘 | ARIANE V ZMOZINSKI T ISABEL C F | 2015 | Talanta2015，134，1： | 1 |
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