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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Clarification of passion fruit juice by microfiltration: Analyses of operating parameters, study of membrane fouling and juice quality 显示文摘 | Ricardo C O Roselene C D Sueli T D B | 2012 | Journal of Food Engineering2012，111，2： | 1 |
| 3 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 4 | Global carbon isotopic events associated with mass extinction and glaciation in the late Ordovician显示文摘 | James D Marshall Patrick J Brenchley Paul Mason George A Wolff Ricardo A Astini Linda Hints T?nu Meidla | 1997 | Palaeogeography Palaeoclimatology Palaeoecology1997，，1： | 1 |
| 5 | Data for similar forms of a food were grouped arid aggregated to match the food显示文摘 | FULEKI T RICARDO D A SILVA J M | 1997 | J Agric Food Chem1997，45，： | 1 |
| 6 | Geology and geochemistry of the Bameys Canyon gold deposit,Utah显示文摘 | Ricardo D Presnell W Parry T | 1996 | Economic Geology1996，91，： | 1 |
| 7 | Modeling of gas-liquid mass transfer in a stirred tank bioreactor agitated by a Rushton turbine or a new pitched blade impeller显示文摘 | Ricardo G A D Ralf T | 2014 | Bioprocess Biosyst Eng2014，37，： | 1 |
| 8 | Catechin and procyanlbin compostion of seeds from gape cultivars grow in ontario显示文摘 | FULEKI T RICARDO D A SILVA J M | 1997 | J Agric Food Chem1997，45，： | 1 |
| 9 | Macrophages in renal development, injury, and repair显示文摘 | WILLIAMS T M LITYLE M H RICARDO S D | 2010 | Sernin Nephrol2010，30，3： | 1 |
| 10 | SNR enhancement of intensity noise-limited FOGs显示文摘 | JAMES B | 2000 | Journal of Lightwave Technology2000，18，12： | 1 |
| 11 | Catechin and procyanlbin compostion of seeds from grape cuhivars grow in ontario 显示文摘 | Fuleki T Ricardo D A Silva J M | 1997 | J Agric Food Chem1997，45，： | 1 |
| 12 | Linear-phase perfect reconstruction filter bank : Lattice structure, design, and application in image coding 显示文摘 | TRAC D T RICARDO L Q | 2000 | IEEE Transactions on Signal Processing2000，48，： | 1 |
| 13 | SNR enhancement of intensity noise-limited FOGs显示文摘 | Renato C R Ricardo T D James B | 2000 | Journal of Lightwave Technology2000，12，： | 1 |
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