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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 3 | Metabolic surgery and intestinal gene expression:Digestive tract and diabetes evolution considerations显示文摘AIM: To investigate the effects of bariatric surgery on metabolic parameters, incretin hormone secretion, and duodenal and ileal mucosal gene expression.METHODS: Nine patients with type 2 diabetes mellitus(T2DM), chronic serum hyperglycemia for more than2 years, and a body mass index(BMI) of 30-35 kg/m2 underwent metabolic surgery sleeve gastrectomy with transit bipartition between May 2011 and December2011. Blood samples were collected pre and 3, 6 and12 mo postsurgery. Duodenal and ileal mucosa samples were collected pre- and 3 mo postsurgery. Pre- and postoperative blood samples were collected in the fasting state before ingestion of a standard meal(520kcal) and again 30, 60, 90, and 120 min after the mealto determine hemoglobin A1c(HbA1c) levels and the lipid profile, which consisted of triglyceride and total cholesterol levels. Intestinal gene expression of p53 and transforming growth factor(TGF)-β was analyzed using quantitative reverse-transcription PCR. Gastric inhibitory polypeptide(GIP) and glucagon-like peptide-1(GLP-1)were quantified using the enzyme-linked immunoassay method and analyzed pre- and postoperatively.Student's t test or repeated measurements analysis of variance with Bonferroni corrections were performed as appropriate.RESULTS: BMI values decreased by 15.7% within the initial 3 mo after surgery(31.29 ± 0.73 vs 26.398± 0.68, P < 0.05) and then stabilized at 22% at 6mo postoperative, resulting in similar values 12 mo postoperatively(20-25 kg/m2). All of the patients experienced improved T2 DM, with 7 patients(78%)achieving complete remission(HbA1c < 6.5%), and 2patients(22%) achieving improved diabetes(HbA1c< 7.0% with or without the use of oral hypoglycemic agents). At 3 mo postoperatively, fasting plasma glucose had also decreased(59%)(269.55 ±18.24 mg/dL vs 100.77 ± 3.13 mg/dL, P < 0.05)with no further significant changes at 6 or 12 mo postoperatively. In the first month postoperatively,there was a complete withdrawal of hypoglycemic medications in all patients, who were taking at least2 hypoglycemic drugs preoperatively. GLP-1 levels significantly increased after surgery(149.96 ± 31.25 vs220.23 ± 27.55)(P < 0.05), while GIP levels decreased but not significantly. p53 gene expression significantly increased in the duodenal mucosa(P < 0.05, 2.06 fold)whereas the tumor growth factor-β gene expression significantly increased(P < 0.05, 2.52 fold) in the ileal mucosa after surgery.CONCLUSION: Metabolic surgery ameliorated diabetes in all of the patients, accompanied by increased antiproliferative intestinal gene expression in non-excluded segments of the intestine. | Marcos Ricardo da Silva Rodrigues Marco Aurelio Santo Giovani Marino Favero Elaine Cristina Vieira Roberto Ferreira Artoni Viviane Nogaroto Egberto Gaspar de Moura Patricia Lisboa Fabio Quirillo Milleo | 2015 | World Journal of Gastroenterology2015，21，22： | 2 |
| 4 | Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study显示文摘 | Andre Castro Lyra Milena Botelho Pereira Soares Luiz Flavio Maia da Silva Eduardo Lorens Braga Sheilla A. Oliveira Marcos Fraga Fortes Andre Goyanna Pinheiro Silva Daniele Brustolim Bernd Genser Ricardo Ribeiro dos Santos Luiz Guilherme Costa Lyra | 2010 | European Journal of Gastroenterology & Hepatology2010，，1： | 2 |
| 5 | Oxygen free radical scavenger capacity in aqueous models of different procya- nidins from grape seeds显示文摘 | RICARDO DA SILVA J M DARMON N FERNANDEZ Y | 1991 | Journal of Agricultural and Food Chemistry1991，39，9： | 1 |
| 6 | Quantification of catechin and poranthocyanidins in several portuguese grapevine varieties and red wines 显示文摘 | Sun B S Ricardo da Silva J Mv Spranger M | 2001 | Ciencia E Tecnica Vitivinico- la2001，16，1： | 1 |
| 7 | Supercritical fluid extraction of lipids from spent coffee grounds显示文摘 | Ricardo M C Joao F Gomes da Silva M D R | 2009 | Journal of Supercritical Fluids2009，51，： | 1 |
| 8 | Procyanidin dimers and trimers from grape seeds显示文摘 | Rigaud Jacques Cheynier Veronique | 1991 | Phytochemistry1991，30，4： | 1 |
| 9 | Design of europium(III) complexes with high quantum yield显示文摘 | Ricardo O. Freire Fabiana R. Gon?alves e. Silva Marcelo O. Rodrigues Maria E. de. Mesquita Nivan B. da Costa. Jùnior | 2005 | Journal of Molecular Modeling2005，，1： | 1 |
| 10 | Oxygen free radical scavenger capacity in aqueous models of different proanthocyanidins from grape seeds 显示文摘 | Ricardo Da Silva JM Darman N Fernandez Y | 1991 | JAgric Food Chem1991，39，9： | 1 |
| 11 | An integrated methodology for environmental impacts and costs evaluation in industrial processes 显示文摘 | Paulo Ricardo Santos da Silva Femando Goncalves Amaral | 2009 | Joumal of Cleaner Production2009，17，15： | 1 |
| 12 | Catechin and procyanidin composition of seeds from deeds from grape cultivars grown in Ontario显示文摘 | and Ricardo da Silva J M | 1997 | J Agric Food Chem1997，45，： | 1 |
| 13 | Procyanidin Dimers and Trimers from Grape Seeds显示文摘 | Jorge M Ricardo Da Silva Jacques Rigaud | 1991 | Phytochemistry1991，30，： | 1 |
| 14 | Fault detection of open-switch damage in voltage-fed pwm motor drive systems显示文摘 | Ricardo Ltlcio de Araujo Ribeiro Cursino Brandao Jacobina Edison Roberto Cabral da Silva | 2003 | IEEE Transactions on Power Electronics2003，18，2： | 1 |
| 15 | Separation of grape and wine proanthocyanidin according to their degree of polymerization显示文摘 | Sun B S Leandro C Ricardo da Silva J M | 1998 | Journal of Agriculture and Food Chemistry1998，46，： | 1 |
| 16 | Effects of annealing on the physicochemical properties of fermented cassava starch (polvilho azedo ) 显示文摘 | Anida M M Gomes Claudio E Mendes da Silva Nagila M P S Ricardo | 2005 | Carbohydrate Polymers2005，60，1： | 1 |
| 17 | Procyanidin dimers and trimers from grape seeds显示文摘 | RICARDO DA SILVA JORGE M RIGAUD JACQUES CHEYNIER VERONIQUE | 1991 | Phytochemistry1991，30，4： | 1 |
| 18 | Separation ofgrapeandwine p roanthocyanidin ac cording to their degree of polymerization显示文摘 | SUNB S LEANDRO C RICARDO DA SILVA J M etal | 1998 | J Agirc Food Chem1998，46，： | 1 |
| 19 | Critical factors of vanillin assay for catechins and proanthocyanidins 显示文摘 | Sun B Ricardo - da - Silva JM Spranger I | 1998 | J Agric Food Chem1998，46，： | 1 |
| 20 | Biological and chemical attributes of soils under forest species in Northeast Brazil显示文摘Timber forests contribute to the sustainable development of the biomes in tropical regions.The aim of this study was to evaluate the biological and chemical properties of the soil as a consequence of the cover with native and non-native species in the Acarau basin,a transition area from the coast to the Brazilian semi-arid region.Areas planted with four native species(Anadenanthera colubrina,Astronium fraxinifolium,Handroanthus impetiginosus,Colubrina glandulosa)and three exotic species(Acacia mangium,Casuarina equisetifolia,Eucalyptus urophylla)plus a non-forested agricultural area were evaluated for organic carbon contents,and microbial and chemical soil properties.The levels of soil organic carbon were highest in A.colubrina and C.equisetifolia plantations.Low basal soil respiration was observed but the microbial biomass was particularly low in the non-forested area.In the C.equisetifolia,E.urophylla,and H.impetiginosus plantations,elevated soil metabolic quotients were found.The A.colubrina and H.impetiginosus plantations had the highest levels of easily extracted-glomalin related soil protein.Tree species affect concentrations of essential nutrients and the biological quality of the soil in different ways.They can also improve the biological and chemical properties of the soil in the coastal plains of tropical regions. | Olmar Baller Weber Maria Catia Barroso da Silva Cristiane Figueira da Silva Joao Alencar de Sousa Carlos Alberto Kenji Taniguch Deborah dos Santos Garruti Ricardo Espindola Romero | 2020 | Journal of Forestry Research2020，31，5： | 1 |
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