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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Influence of sex on lung cancer histology, stage, and survival in a midwestern United Statestumor registry 显示文摘 | Ringer G Smith JM Engel AM | 2005 | Clin Lung Cancer2005，7，3： | 1 |
| 3 | Arsenic trioxide inhibits human cancer eell growth and tumor development in mice by bloeking Hedgehog/GLI pathway显示文摘 | Beauehamp EM Ringer L Bulut G | 2011 | J Clin Invest2011，121，1： | 1 |
| 4 | Privatized ad- ministration o{ the national laboratories~developments in the government-owned, contractor-operated approach显示文摘 | RAINEY H G RINGER B KINGSLEY G | 2004 | Public Per{ormance Management Review2004，28，2： | 1 |
| 5 | Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking hedgehog/gli pathway显示文摘 | Beauchamp EM Ringer L Bulut G | 2011 | J Clin Invest2011，121，1： | 1 |
| 6 | Introducing a strain-hardening capability to improve the ductility of bulk metallic glasses via severe plastic deformation 显示文摘 | WANG Y B QU D D WANG W H CAO Y LIAO X Z KAWASAKI M RINGER S P SHAN Z W LANGDON T G SHEN J | 2012 | Acta Mater2012，60，： | 1 |
| 7 | Intrapartum tempera- ture elevation, epidural use, and adverse outcome in term infants 显示文摘 | Greenwell EA Wyshak G Ringer SA | 2012 | Pediatrics2012，129，2： | 1 |
| 8 | Arsenic tri- oxide inhibits human cancer cell growth and tumor de-velopment in mice by blocking Hedgehog/GLI pathway 显示文摘 | Beauchamp EM Ringer L Bulut G | 2011 | J Clin Invest2011，121，： | 1 |
| 9 | The effect of dislocation density on the interactions between dislocations and twin boundaries in nanocrystalline materials显示文摘 | NI S WANG Y B LIAO X Z FIGUEIREDOB R B LI H Q RINGER S P LANGDON T G ZHU Y T | 2012 | Acta Materialia2012，60，： | 1 |
| 10 | Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/Gli pathway 显示文摘 | BEAUCHAMP EM RINGER L BULUT G | 2011 | J Clin Invest2011，121，1： | 1 |
| 11 | Nanostructure of aluminium alloy 2024: Segregation, clustering and precipitation processes 显示文摘 | SHA G MARCEAU R K W GAO X MUDDLE B C RINGER S P | 2011 | Acta Materialia2011，59，16： | 1 |
| 12 | Influence of sex on lung cancer histology, stage, and survival in a midwestern United States tumor registry 显示文摘 | Ringer G Smith JM Engel AM | 2005 | CIin Lung Cancer2005，7，3： | 1 |
| 13 | Solute clustering,segregation and microstructure in high strength low alloy Al-Cu-Mg alloys显示文摘 | Quan G C Sakurai T | 1998 | Mater Sci Eng A1998，250，： | 1 |
| 14 | Prospective randomised trial of povidone-iodine,alcohol,and chlorhexidine for prevention of infection associated with central venous and arterial catheters显示文摘 | Maki D G Ringer M Alvarado C J | 1991 | Lancet1991，338，8763： | 1 |
| 15 | Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway 显示文摘 | Beauchamp EM Ringer L Bulut G | 2011 | J Clin Invest2011，121，1： | 1 |
| 16 | Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway显示文摘 | Beauchamp EM Ringer L Bulut G | 2011 | J Clin Invest2011，121，1： | 1 |
| 17 | The effect of dislocation density on the interactions between dislocations and twin boundaries in nanocrystalline materials 显示文摘 | NI S WANG Y B LIAO X Z FIGUEIREDO R B LI H Q RINGER S P LANGDON T G ZHU Y T | 2012 | Acta Mater2012，60，： | 1 |
| 18 | Identificationof the material properties of Al 2024 alloy by means of inverseanalysis and indentation tests 显示文摘 | Moy C K S Bocciarelli M Ringer S P Ranzi G | 2011 | Materials Science andEngineering A2011，529，25： | 1 |
| 19 | Isotropic interaction potentials for He-HCl and He-HBr from differential scattering cross section measurements显示文摘 | Held W D Piper E Ringer G | 1980 | Chem Phys Lett1980，75，： | 1 |
| 20 | Sclute clustering,segregation and microstructure in high strength low alloy Al-Cu-Mg alloys显示文摘 | Ringer S P Quan G C Sakurai T | 1998 | Mater Sci Eng1998，250，： | 1 |
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