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| 1 | Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L.in growing pigs by transcriptomics, metabolomics and lipidomics显示文摘Background:The hypothesis was tested that insect meal(IM)as protein source influences intermediary metabolism of growing pigs.To test this,30 male,5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights(BW)and fed isonitrogenous diets either without(CON)or with 5%IM(IM5)or 10%IM(IM10)from Tenebrio molitor L.for 4 weeks and key metabolic tissues(liver,muscle,plasma)were analyzed using omics-techniques.Results:Most performance parameters did not differ across the groups,whereas ileal digestibilities of most amino acids were 6.7 to 15.6%-units lower in IM10 than in CON(P<0.05).Transcriptomics of liver and skeletal muscle revealed a total of 166 and 198,respectively,transcripts differentially expressed between IM10 and CON(P<0.05).Plasma metabolomics revealed higher concentrations of alanine,citrulline,glutamate,proline,serine,tyrosine and valine and a lower concentration of asparagine in IM10 than in CON(P<0.05).Only one out of fourteen quantifiable amino acid metabolites,namely methionine sulfoxide(MetS),in plasma was elevated by 45%and 71%in IM5 and IM10,respectively,compared to CON(P<0.05).Plasma concentrations of both,major carnitine/acylcarnitine species and bile acids were not different across groups.Lipidomics of liver and plasma demonstrated no differences in the concentrations of triacylglycerols,cholesterol and the main phospholipids,lysophospholipids and sphingolipids between groups.The percentages of all individual phosphatidylcholine(PC)and phosphatidylethanolamine(PE)species in the liver showed no differences between groups,except those with 6 double bonds(PC 38:6,PC 40:6,PE 38:6,PE 40:6),which were markedly lower in IM10 than in CON(P<0.05).In line with this,the percentage of C22:6n-3 in hepatic total lipids was lower in IM10 than in the other groups(P<0.05).Conclusions:Comprehensive analyzes of the transcriptome,lipidome and metabolome of key metabolic tissues indicate that partial or complete replacement of a conventional protein source by IM in the diet has only a weak impact on the intermediary metabolism of growing pigs.Thus,it is concluded that IM from Tenebrio molitor L.can be used as a dietary source of protein in pigs without causing adverse effects on metabolism. | Sandra Meyer Denise K.Gessner Maria S.Braune Theresa Friedhoff Erika Most Marcus Höring Gerhard Liebisch Holger Zorn Klaus Eder Robert Ringseis | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 4 |
| 2 | Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron显示文摘 | Wen G Ringseis R Eder K | 2010 | Biochem Pharmacol2010，79，5： | 1 |
| 3 | Cognitive diversity and con-sensus in group decision making:the roles of inputs,process,and outcomes显示文摘 | Mohammed S Ringseis E | 2001 | Organizational Behavior andHuman Decision Process2001，85，2： | 1 |
| 4 | Influence of a rumen- protected conjugated linoleic acid mixture on carcass traits andmeat quality in young Simmental heifers显示文摘 | Schlegel G Ringseis R Shibani M | 2012 | Journal of Animal Science2012，90，5： | 1 |
| 5 | Dietary oxidized fat activates the oxidative stress-responsive transcription factors NF-kB and Nrf2 in intestinal mucosa of mice显示文摘 | Varady J Eder K Ringseis R | | 0，，08： | 1 |
| 6 | Peptides and hydrolysates from casein and soy protein modulate the release of vasoactive substances from human aortic endothelial cells显示文摘 | Ringseis R Matthes B Lehmann V | 2005 | Biochim et Biophysica Acta2005，1721，： | 1 |
| 7 | Cognitive Diversity and Consensus in Group Decision Making: The Role of Inputs, Processes, and Outcomes显示文摘 | Susan Mohammed Erika Ringseis | 2001 | Organizational Behavior and Human Decision Processes2001，，2： | 1 |
| 8 | Supplementation with l -carnitine downregulates genes of the ubiquitin proteasome system in the skeletal muscle and liver of piglets显示文摘 | J. Keller R. Ringseis A. Koc I. Lukas H. Kluge K. Eder | 2011 | animal2011，，1： | 1 |
| 9 | Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity : evidence fix>m in vivo and in vitro Studies with carnitine supplementation and carni-tine deficiency显示文摘 | Robert Ringseis Janine Keller Klaus Eder | 2012 | European Journal of Nutrition2012，51，1： | 1 |
| 10 | Peptides and hydrolysates from casein and soy protein modulate the release of vasoactive substances from human aortic endothelial cells显示文摘 | Ringseis R Matthes B Lehmann V Becker K Schfps R | 2005 | Biochimica ET Biophysica Acta2005，17，21： | 1 |
| 11 | Cognitive diversity and consensus in group decision making: the role of inputs, processes, and outcomes 显示文摘 | Mohammed S Ringseis E | 2001 | Organizational Behavior and Human Decision Processes2001，85，： | 1 |
| 12 | The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trime- thylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor α显示文摘 | Wen G Ringseis R Rauer C | 2012 | Biochimica et Biophysica Acta (BBA)-Gene Regula- tory Mechanisms2012，1819，5： | 1 |
| 13 | Genes involved in ear- nitine synthesis and carnitine uptake are up-regulated in the liver of sows during lactation显示文摘 | Rosenbaum S Ringseis R Most E et a/ | 2013 | Acta Vet Scand2013，55，： | 1 |
| 14 | Regulation of genes in- volved in carnitine homeostasis by PPARa across dif- ferent species (rat, mouse, pig, cattle, chicken, and hu- man) 显示文摘 | Ringseis R Wen G Eder K | 2012 | PPAR Research2012，2012，： | 1 |
| 15 | Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species显示文摘 | Ringseis R Wege N Wen G | 2009 | The Jour- nal of Nutritional Biochemistry2009，20，11： | 1 |
| 16 | Genes in- volved in carnitine synthesis and carnitine uptake are up-regulated in the liver of sows during lactation显示文摘 | Rosenbaum S Ringseis R Most E | 2013 | Acta Veterinaria Scandinavica2013，55，1： | 1 |
| 17 | Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metallopro-teinases-2 and -9 in PMA-differentiated THP-1 macrophages显示文摘 | Ringseis R Schulz N Saal D | 2008 | J Nutr Biochem2008，19，9： | 1 |
| 18 | Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers显示文摘 | Ringseis R Rosenbaum S Gessner D K | 2013 | The Journal of Nutrition2013，143，2： | 1 |
| 19 | Supplementation with L-carnitine downregulates genes of the ubiquitin proteasome system in the skeletal muscle and liver of piglets显示文摘 | Keller J Ringseis R Koe A | 2012 | Animal2012，6，1： | 1 |
| 20 | Cognitive Diversity and Consensus in Group Decision Making:The Role of Inputs,Processes,and Outcomes显示文摘 | Mohammed S Ringseis E | 2001 | Organizational Behavior and Human Decision Processes2001，85，2： | 1 |
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