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| 1 | Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms显示文摘Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow diverters.Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications afterwards.We sought to determine the safety of tirofiban and DAPT in these cases.Methods We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow diversion.The tirofiban-DAPT protocol used is described.Data regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and analysed.results One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 electively.Minor and major haemorrhagic events were recognised in 20%(30/148)aneurysms.Only 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 EVD-related.The average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were symptomatic.Most haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was documented.Concomitant administration of heparin did not increase haemorrhagic events.Conclusion The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was safe.Tirofiban and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications. | Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan | 2019 | Stroke & Vascular Neurology2019，4，1： | 17 |
| 2 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 3 | The impact of cy- clic wettingand drying on the swelling behaviour of stabilized expansive soils 显示文摘 | Roa S M Reddy B V V Muttharam M | 2001 | Engineering Geology2001，60，： | 1 |
| 4 | A novel mathematical method based on urea kinetic modeling for computing the dialysis dose 显示文摘 | Prado M Roa L Palma A | 2004 | Comput Methods Programs Biomed2004，74，： | 1 |
| 5 | p53 tumor sup-pressor gene protein expression in early and advanced gallbladdercarcinoma显示文摘 | Roa I Villaseca M Araya J | 1997 | Histolpathology1997，31，3： | 1 |
| 6 | Venlafaxine extended- release in patients older than 80 years with depressive syndrome显示文摘 | Baea E Roa M Gareia-Calvo C | 2006 | Int J Geriatr Psychiatry2006，21，4： | 1 |
| 7 | Evaluations of water activity measurements with a dew point electronic humidity meter显示文摘 | Roa V Tapia de Daza M S | 1991 | Lebensmittel Wissenschaft und Technologie1991，24，： | 1 |
| 8 | Preneoplastic lesions and gallbladder cancer: an estimate of the period require for progression 显示文摘 | Roa I Araya J Villaseca M et a l | 1996 | Gastroenterology1996，111，7： | 1 |
| 9 | Long-term effect of bifidobacteria and neosurgar on precursor Iesions of colonic cancer in GF mice 显示文摘 | KOO M and ROA A V | 1991 | Nutr Cancer1991，16，： | 1 |
| 10 | Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome 显示文摘 | Roa Barrios M Arata-Bellabarba G Valeri L | 2009 | Endocrinol Nutr2009，56，： | 1 |
| 11 | Antihypertensive combi- nation therapy in primary care offices~ results of a cross-sectional survey in Switzerland显示文摘 | Roas S Bernhart F Schwarz M | 2014 | Int J Gen Med2014，7，： | 1 |
| 12 | Expression of KiSS-1in rat oviduct:possible involvement in prevention of ectopic implantation?显示文摘 | Gaytán M Castellano J M Roa J | 2007 | Cell Tissue Res2007，329，3： | 1 |
| 13 | Assessment of synthetic zeolite NaA-X as sorbing barrier for strontium in a radioactive disposal facility显示文摘 | Rahman ROA Ibrahim HA l-Ianafy M | 2010 | Chem Eng J2010，157，1： | 1 |
| 14 | Detección del shunt intrapulmonar en pacientes con cirrosis hepática mediante doppler transcraneal con contraste. Estudio de prevalencia, caracterización del patrón y validez diagnóstica显示文摘 | José María Ramírez Moreno María Victoria Millán Nú?ez Marta Rodríguez Carrasco David Ceberino Olena Romaskevych-Kryvulya Ana Belén Constantino Silva Pedro Mu?oz-Vega Carmen García-Corrales Ana Guiberteau-Sánchez Ana Roa Montero Patricia Márquez-Lozano Isi | 2015 | Gastroenterologia y Hepatologia2015，，8： | 1 |
| 15 | p53 tumour suppressor gene protein expression in early and advanced gallbladder carcinoma显示文摘 | Roa I Villaseca M Araya J | 1997 | J Histopathology1997，31，3： | 1 |
| 16 | Kisspeptins and the control of gonadotropin secre- tion in male and female rodents 显示文摘 | ROA J CASTELLANO J M NAVARRO V M | 2009 | Peptides2009，30，1： | 1 |
| 17 | Expression of KiSS-1 in rat ovary:putative local regulator of ovulation?显示文摘 | Castellano J M Gaytan M Roa J | 2006 | Endocrinology2006，147，10： | 1 |
| 18 | Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio,insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome显示文摘 | Roa Barrios M Arata-Bellabarba G | 2009 | Endocrinol Nutr2009，56，2： | 1 |
| 19 | Direct stim- ulatory effect of ghrelin on pituitary release of LH through a nitric ox- ide-dependent mechanism that is modulated by estregen显示文摘 | Fenaandez-Femandez R Tena-Sempere M Roa J | 2007 | Repro- duction2007，133，6： | 1 |
| 20 | Synthesis of a CrCoAPO-5 (AFI) molecular sieve and its activity in cyclohexane oxidation in the liquid phase显示文摘 | Anthony F M James K B Roa A L | 2001 | Catal Lett2001，75，34： | 1 |
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