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| 1 | Management and outcome of hepatocellular adenoma with massive bleeding at presentation显示文摘AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma(HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage(grade Ⅱ or Ⅲ) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging(MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short-and long-term complications and patient and lesion follow-up. RESULTS All patients were female(n = 23). Treatment in the acute phase consisted of embolization(n = 9, 39.1%), conservative therapy(n = 13, 56.5%), andother intervention(n = 1, 4.3%). Median hemoglobin level decreased significantly more on days 0-3 in the intervention group than in the patients initially treated conservatively(0.9 mmol/L vs 2.4 mmol/L respectively, P = 0.006). In total, 4 patients suffered severe shortterm complications, which included hypovolemic shock, acute liver failure and abscess formation. After a median follow-up of 36 mo, tumor regression in nonsurgically treated patients occurred with a median reduction of 76 mm down to 25 mm. Four patients underwent secondary(elective) treatment(i.e., tumor resection) to address HCA size of > 5 cm and/or desire for future pregnancy. One case of rebleeding was documented(4.3%). None of the patients experienced long-term complication(mean follow-up time: 36 mo). CONCLUSION With a 4.3% risk of rebleeding, secondary(elective) treatment of HCA after massive hemorrhage may only be considered in patients with persistent HCA > 5 cm. | Anne J Klompenhouwer Robert A de Man Maarten GJ Thomeer Jan NM Ijzermans | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Eicosapentanoic acid inhibits hypoxia - reoxygenation - induced injury by attenuating upregulation of MMP - 1 in adult rat myocytes显示文摘 | Chert H Li D Roberts GJ | 2003 | Cardiovasc Res2003，59，： | 1 |
| 3 | Recent advances in the molecular genetics of primary gliomas 显示文摘 | Kitange GJ Templeton Kristen LBA Jenkins Robert B | 2003 | Curr Opini Oncol2003，15，： | 1 |
| 4 | Mitochondrial function and oxygen supply in normal and in chronically ischemic muscle: a combined ^31p magnetic resonance spectroscopy and near infrared spectroscopy study in vivo显示文摘 | Kemp GJ Roberts N Bimson WE | 2001 | J Vasc Surg2001，34，6： | 1 |
| 5 | Experimentally- derived functional form for a population-averaged high-temporal- resolution arterial input function for dynamic contrast-enhanced MRI显示文摘 | Parker GJ Roberts C Macdonald A | 2006 | Magn Reson Med2006，56，： | 1 |
| 6 | The radiographic localization of impacted maxillary canines:a comparison of methods 显示文摘 | Mason C Papadakou P Roberts GJ | 2001 | Eur J Orthod2001，23，1： | 1 |
| 7 | Long - term out- comes of nephroureterectomy versus endoscopic management for upper tract urothelial carcinoma 显示文摘 | Gadzinski A J Roberts WW Faerber GJ | 2010 | The Journal of urology2010，183，6： | 1 |
| 8 | Short root anomaly显示文摘 | Edwards DM Roberts GJ | 1990 | Br Dent J1990，169，9： | 1 |
| 9 | Effect of mutant IkappaB on cytokine-induced activation of NF-KappaB in cultured human RPE cells显示文摘 | Yang P McKay BS Allen JB Roberts WL Jaffe GJ | 2003 | Invest Ophthalmol Vis Sci2003，44，3： | 1 |
| 10 | Oral sedation for dental treatment in young children in a hospital setting显示文摘 | Lourenco-Matharu L Roberts GJ | | 0，，07： | 1 |
| 11 | Effect of human milk on plaque pH in situ and enamel dissolution in compared with bovine milk, lactose, and human milk 显示文摘 | Rugg-Gunn AJ Roberts GJ Wright WG | 1985 | Caries Res1985，19，4： | 1 |
| 12 | Extended Hypermetabolic Response of the Liver in Severely Burned Pediatric Patients显示文摘 | Marc GJ Robert EB David N | 2004 | Arch Surg2004，139，： | 1 |
| 13 | Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study 显示文摘 | Hawkins TL Roberts JM Mangos GJ | 2012 | BJOG2012，119，4： | 1 |
| 14 | Improving chemoradiotherapy in rectal cancer显示文摘 | | 2001 | Oncologist2001，6，4： | 1 |
| 15 | Use of calcium hydroxide for apical barrierformation and healing in non-vital immature permanent teeth: a re- view显示文摘 | Sheehy EC Roberts GJ | 1997 | Br Dent J1997，183，7： | 1 |
| 16 | Effect of human milk on plaque pH in situ and enamel dissolution in compared with bovine milk, lactose, and human milk 显示文摘 | Roberts GJ Wright WG | 1985 | Caries Res1985，19，： | 1 |
| 17 | The radiographic localization of impacted maxillary canines: a comparison of methods显示文摘 | Mason C Papadakou P Roberts GJ | 2001 | Eur J Orthod2001，23，1： | 1 |
| 18 | The radiographic localization of impacted maxillarg canines: a comparison of methods显示文摘 | Mason C Papadayou P Roberts GJ | 2001 | Eur J Orthod2001，23，： | 1 |
| 19 | Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance显示文摘 | Jean - Louis C Robert GJ Ramon G | 2003 | JAMA2003，290，4： | 1 |
| 20 | Risk factors for inci- dence and severity of white spot lesions during treatment with fixed orthodontic appliances显示文摘 | Chapman J Roberts WE Eckert GJ | 2010 | Am J Orthod Dentofacial Or- thop2010，138，2： | 1 |
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