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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 3 |
| 3 | NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD. | Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 4 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 5 | On parameter identifiability of MIMO radar 显示文摘 | Li J Stoica P Xu L Z Roberts W | 2007 | IEEE Signal Processing Letters2007，14，12： | 1 |
| 6 | Changes in stoichiometric Si, N and P ratios of Mississippi River water diverted through coastal wetlands to the Gulf of Mexico 显示文摘 | Robert R L John W D Dubravko J | 2004 | Estuarine Coastal and Shelf Science2004，60，1： | 1 |
| 7 | Determination of polystyrene-carbon dioxide- decahydronaphthalene solution properties by high pressure dynamic light scattering显示文摘 | Dong L B Carbonell R G Roberts G W | 2009 | Polymer2009，50，24： | 1 |
| 8 | The Effect of a Translucent Post on Resin Composite:Depth of Cure显示文摘 | Roberts H W Leonard D L Vandew alle K S | | 0，，07： | 1 |
| 9 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 10 | Distal femoral allograft for massive proximal femoral deficiency显示文摘 | Robert L B Michaei W W Paul M | 2008 | Acta Orthop Scand2008，7，： | 1 |
| 11 | Cellular concentrations and uniformity of cell-type accumulation of two LEA proteins in cotton embryos显示文摘 | Roberts J K Desimone N A Lingle W L | 1993 | Plant Cell1993，5，7： | 1 |
| 12 | Dialkylimidazo- lium Chloroaluminate Melts: A New Class of Room-Temper- ature Ionic Liquids for Electrochemistry, Spectroscopy, and Synthesis 显示文摘 | John S W Joseph A L Robert A W | 1982 | Inorg Chem1982，21，： | 1 |
| 13 | Personality deve-lopment:stability and change显示文摘 | CASPI A ROBERTS B W SHINER R L | 2005 | Annu Rev Psychol2005，56，： | 1 |
| 14 | Integrating a global positioning system and accelerometers to monitor the deflection of bridges显示文摘 | ROBERTS G W MENG X L DODSON A H | 2004 | Journalof Surveying Engineering2004，130，5： | 1 |
| 15 | Porcine uterine retinol-binding proteins are identical gene products to the serum retinol-binding protein显示文摘 | Stallings-Mann M L Trout W E Roberts R M | 1993 | Biol Reprod1993，48，5： | 1 |
| 16 | Determinants of bovine thermal response to heat and solar radiation exposures in a field environment显示文摘 | Scharf B Michael J L Robert L W | 2011 | International Journal of Biometeorology2011，55，4： | 1 |
| 17 | Acinetobacter infection显示文摘 | MUNOZ PRICE L S ROBERT A W | 2008 | N Engl J Med2008，358，12： | 1 |
| 18 | Assessing Dependence : Some Experimental Results 显示文摘 | Robert T Clemen Gregory W Fischer Robert L Winkler | 2000 | Management Science2000，46，8： | 1 |
| 19 | pH Homeostasis in lactic acid Bacteria显示文摘 | Robert W H Nancy L N | 1993 | J Dairy sci1993，76，08： | 1 |
| 20 | Association of unconventional myosin15 mutations withhuman nonsyndromic deafness DFNB3显示文摘 | 10,Aihui W Yong L Robert AF | 1998 | Science1998，280，： | 1 |
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