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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Efficacy of some biodegradable films as pre-harvest covering material for guava显示文摘 | Bilck A P Roberto S R Eiras Grossmann M V | 2011 | Scientia Horticulturae2011，130，1： | 1 |
| 3 | Application of purge and trap extraction and gas chromatography for determination of minor esters in cider显示文摘 | ROBERTO R M NOEM P G ANA G H | 2005 | Journal of chromatography A2005，1069，2： | 1 |
| 4 | A comparative study of the glucose,white blood cell count,interleukin-6,and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes 显示文摘 | Roberto R Yoon B H Moshe M el al | 1993 | Am J Obstet Gynecol1993，169，： | 1 |
| 5 | Appli- cation of conventional solid-phase extraction for multimycotoxin analysis in beers by ultra- high-performance liquid chromatography-tandem mass spectrometry 显示文摘 | Roberto R G Jose L M Aguilera M M | 2009 | Journal of Agricultural and Food Chemistry2009，57，20： | 1 |
| 6 | Thermogravimetric studies on the effect of support in sorbent-materials applied to flue gas desulfurization 显示文摘 | ROBERTO F ARTURO R CINTHYA P YULIANA M XOCHITL M LAURA G | 2008 | Fuel2008，87，： | 1 |
| 7 | Wax formation in the pyrolysis of polyolefins in a conical spouted bed reactor 显示文摘 | Roberto A R Olazar M San Jose M J | 2002 | Energy &Fuels2002，16，： | 1 |
| 8 | Preparation of (2R,3R)-Ethyl 1-1-Benzhydryl-3-(4-bromophenyl)aziridine 2-Carboxylate显示文摘 | AMAN A D ROBERTO M R WILLIAM D W | 2011 | Org Synth2011，88，： | 1 |
| 9 | 查看详情显示文摘 | María L G P Patricia P B Roberto R G José L M V Antonia G F | | 0，，27： | 1 |
| 10 | Predictive modeling of mi- crohabitats for endemic birds in south Chilean temperate forests using Maximum entropy ( Maxent ) 显示文摘 | Roberto M Zamora R Ram6n J | 2011 | Eeol Inform2011，6，： | 1 |
| 11 | Effeet of eider maturation on the chemical and sensory characteristics of fresh eider spirits显示文摘 | Roberto R M Anna P L Juan J M A | 2010 | Food Research International2010，43，： | 1 |
| 12 | Adsorption of fluoride from water solution on bone char显示文摘 | NAHUM A M C ROBERTO L R RAUL O P | 2007 | Industrial Engineering Chemistry Research2007，46，26： | 1 |
| 13 | Estimating Shocks and Impulse Response Functions 显示文摘 | Wickens Michael R Roberto M | 2001 | Journal of Applied Econometrics2001，，16： | 1 |
| 14 | Predictive modeling of microhabitats for endemic birds in Soueh Chilean temperate forests using Maximum enlropy(Maxent) 显示文摘 | Roberto M Zamora R Ramon J | 2011 | Ecological Informatics2011，6，： | 1 |
| 15 | Spanish-Latin American Multicenter Study of Attitudes Toward Organ Donation Among Personnel From Hospital Healthcare Centers显示文摘 | Antonio Ríos Ana López-Navas Marco Antonio Ayala-García María José Sebastián Anselmo Abdo-Cuza Jeannina Alán Laura Martínez-Alarcón Ector Jaime Ramírez Gerardo Mu?oz Juliette Suárez-López Roberto Castellanos Ricardo Ramírez Beatriz González Miguel Angel M | 2013 | Cirugía Espa?ola (English Edition)2013，，： | 1 |
| 16 | In vitro cytotoxic effect of wheat gliadin-derived peptides on the Caco-2 intestinal cell line is associated with intracellular oxidative imbalance:implications for coeliac disease显示文摘 | Roberto R Elena M Massimo D V | 1999 | Biochimica et Biophysica Acta1999，1453，： | 1 |
| 17 | Mechanisms of cardiovas cular changes in an experimental model of syndrome X and pharmacological intervention on the renin-angiotensin-system显示文摘 | Montserrat C Norma R | 2004 | Current Vascular Pharmacology2004，2，： | 1 |
| 18 | Batch xylitol production by Candida guilliermondii FTI20037from sugarcane bagasse hemicellulosic hydrolyzate at controlled pH values显示文摘 | R C L B Rodrigues M G A Felipe I C Roberto | 2003 | Bioprocess Biosyst Eng2003，26，： | 1 |
| 19 | A comparative study of the glucose,white blood cell count,interleukin 26,and Gram stain in the detection lf microbial invasion in patients with preterm premature rupture of membranes显示文摘 | Roberto R Yoon Bh Moshe M | 1993 | Am J Obstet Gynecol1993，169，： | 1 |
| 20 | The gas diffusion layer in polymer electrolyte membrane fuel cells: a process model of the two phase flow 显示文摘 | Roberto L N Richard H R Michael M Kai S | 2011 | International Journal of Hydrogen Energy2011，36，16： | 1 |
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