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| 1 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 2 | Sludge dewatering and stabilization in drying reed beds:characterization of three full-scale systems in Catolonia,Spain显示文摘 | ENRICA U ESTHER L ANNA P | 2009 | Bioresource Technology2009，100，17： | 1 |
| 3 | Drafting the Genetic Privacy Act: Science, Policy and Practical Considerations显示文摘 | Annas G J Glantz L H Roche P A | 1995 | The Journal of Law Medicine and Ethics1995，23，4： | 1 |
| 4 | Reconstructing long time series of burned areas in arid grasslands of southern russia by satellite re- mote sensing显示文摘 | Maxim D Peter P Anna L | 2010 | Remote Sensing of Environment2010，114，8： | 1 |
| 5 | Determination of or- ganophosphorous flame reretardants in fish tissues by ma- trix solid- phase dispersion and gas chromatography 显示文摘 | Luca C Anna L P Conny O | 2010 | Anal Bioanal Chem2010，397，3： | 1 |
| 6 | Structure and correlations of the flux line lattice in crystalline Nb through the peak effect显示文摘 | Gammel P L Yaron U Ramirez A P Bishop D J Chang A M Ruel R Pfeiffer L N Bucher E D'Anna G Huse D A Mortensen K Eskildsen M R Kes P H | | 0，，： | 1 |
| 7 | Micropropagation of Eurycoma longifolia Jack via Formation of Somatic Embryogenesis显示文摘 | Sobri H Rusli I Anna L P K | 2005 | Asian Journal of Plant Sciences2005，4，47： | 1 |
| 8 | Multiple shoots formation of an important tropical medicinal plant, Eurycoma longifoliaJack显示文摘 | Hussein S Rusli I Anna L P K | 2005 | Plant Biotechnol2005，22，： | 1 |
| 9 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 10 | Effeet of eider maturation on the chemical and sensory characteristics of fresh eider spirits显示文摘 | Roberto R M Anna P L Juan J M A | 2010 | Food Research International2010，43，： | 1 |
| 11 | Phenolic and antioxidant composition of by-products from the cider industry:apple pomace显示文摘 | García Y D Belén S V Anna P L | 2009 | Food Chem2009，117，： | 1 |
| 12 | Towards understanding of physiological changes in cell culture of recalcitrant woody plant,Eurycoma longifolia, in response to carbon and nitrogen sources显示文摘 | Francis C P Anna P K Siew L H | 2011 | Journal of Medicinal Plants Research2011，5，14： | 1 |
| 13 | Cosmeceutical peptides显示文摘 | Mary P L Anna L | | 0，，05： | 1 |
| 14 | Changes of rheologieal properties of apple tissue undergoing convective drying显示文摘 | LEWICKI P P ANNA L | 2000 | Drying Technology2000，18，3： | 1 |
| 15 | Women business owners in traditional and non - traditional indus-tries显示文摘 | Anna A L Chandler G N Jansen E Mero N P | 2000 | Journal of Business Venturing2000，15，3： | 1 |
| 16 | Determina lion of organophosl?horous flame retardants in fisb lis sues by matrix solid phase dispersion and gas chroma tography显示文摘 | LUCA C ANNA L P CONNY O | 2010 | Anal Bioanal Chem2010，397，3： | 1 |
| 17 | Phenolic and antioxidant compo- sition of by-products from the cider industryt Apple pomace 显示文摘 | Garcia Y D Bel6n S V Anna P L | 2009 | Food Chem2009，117，： | 1 |
| 18 | Impact of rapid on‐site evaluation on the adequacy of endoscopic‐ultrasound guided fine‐needle aspiration of solid pancreatic lesions: A systematic review and meta‐analysis显示文摘 | Anna P Matynia Robert L Schmidt Gonzalo Barraza Lester J Layfield Ali A Siddiqui Douglas G Adler | 2014 | J Gastroenterol Hepatol2014，，4： | 1 |
| 19 | Vascular smooth muscle cell dysfunction in patients with migraine显示文摘 | R Napoli V Guardasole E Zarra M Matarazzo C D?Anna F Saccà F Affuso A Cittadini P B. Carrieri L Saccà | 2009 | Neurology2009，，24： | 1 |
| 20 | Determination of or- ganophosphorous flame retardants in fish tissues by ma- trix solid-phase dispersion and gas chromatography显示文摘 | Luca C Anna L P Conny O | 2010 | Anal Bioanal Chem2010，397，3： | 1 |
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