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| 1 | Role of axon resealing in retrograde neuronal death and regeneration after spinal cord injury显示文摘Spinal cord injury leads to persistent behavioral deficits because mammalian central nervous system axons fail to regenerate. A neuron's response to axon injury results from a complex interplay of neuron-intrinsic and environmental factors. The contribution of axotomy to the death of neurons in spinal cord injury is controversial because very remote axotomy is unlikely to result in neuronal death, whereas death of neurons near an injury may reflect environmental factors such as ischemia and inflammation. In lampreys, axotomy due to spinal cord injury results in delayed apoptosis of spinal-projecting neurons in the brain, beyond the extent of these environmental factors. This retrograde apoptosis correlates with delayed resealing of the axon, and can be reversed by inducing rapid membrane resealing with polyethylene glycol. Studies in mammals also suggest that polyethylene glycol may be neuroprotective, although the mechanism(s) remain unclear. This review examines the early, mechanical, responses to axon injury in both mammals and lampreys, and the potential of polyethylene glycol to reduce injury-induced pathology. Identifying the mechanisms underlying a neuron's response to axotomy will potentially reveal new therapeutic targets to enhance regeneration and functional recovery in humans with spinal cord injury. | William Rodemer Michael E.Selzer | 2019 | Neural Regeneration Research2019，14，3： | 4 |
| 2 | Separate DNA elements containing ATF/CREB and IE86 binding sites differentially regulate the human cytomegalovirus UL112-113 promoter at early and late times in the infection显示文摘 | Rodems SM Clark CL Spector DH | 1998 | J Virol1998，72，4： | 1 |
| 3 | Mandibular reconstruction with cancellous bone,hydroxylapatite and titanium mesh显示文摘 | Dumbach J Rodemer H Spitzer WJ | 1994 | J Craniomaxillofac Surg1994，22，3： | 1 |
| 4 | Treatment of complex mandibular fractures using titanium mesh显示文摘 | Schug T Rodemer H Neupert W | 2000 | J Craniomaxillofac Surg2000，28，4： | 1 |
| 5 | Drug-induced prolongation of the QT interval 显示文摘 | Rodem DM | 2004 | New England Journal of Medicine2004，350，10： | 1 |
| 6 | Effect of simvasta- tin on MMPs and TIMPs in human brain endothelial ceils and ex- perimental stroke 显示文摘 | Reuter B Rodemer C Grudzenski S | 2015 | Transl Stroke Res2015，6，2： | 1 |
| 7 | A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases 显示文摘 | Rodems SM Hamman BD Lin C | 2002 | Assay Drug Dev Technol2002，1，11： | 1 |
| 8 | Extracellular signal- regulated kinase activity is sustained early during human cytomegalovirus infection显示文摘 | Spector DH | 1998 | J Virol1998，72，： | 1 |
| 9 | Gonadal development of the chick embryo following microsurgically caused agenesis of the mesonephros and using interspecific quail-chick chimaeras 显示文摘 | Rodemer S Alice I Wartenberg H | 1986 | J Embryol Exp Morphol1986，98，： | 1 |
| 10 | Limits of osseous reconstruction of themandible with autologous spongiosa hydroxyapatite granules and titanium mesh especiallyafter radiotherapy显示文摘 | Dumbach J Rodemer H Spitzer WJ | 1994 | Forstschr-Kiefer-Gesichtschir1994，39，： | 1 |
| 11 | Extracellular Signal-Regulated Kinase Activity Is Sustained Early during Human Cytomegalovirus Infection显示文摘 | Rodems SM Spector DH | 1998 | J Virol1998，72，11： | 1 |
| 12 | DNA-dependent transregulation by IE1 A utographa californica nuclear polyhedrosis virus:IE1 domains required for transactivation and DNA binding显示文摘 | Rodems S M Pullen S S Friesen P D | 1997 | J Virol1997，71，12： | 1 |
| 13 | Temporal profile of matrix metalloproteinases and their Inhibitors in a human endothelial cell culture model of cerebral ischemia 显示文摘 | Reuter B Rodemer C Grudzenski S | 2013 | Cerebrovasc Dis2013，35，6： | 1 |
| 14 | Mandibular reconstruction with cancellous bone,hydroxylapatite and titanium mesh显示文摘 | Dumbach J Rodemer H Spitzer WJ | | 0，，3： | 1 |
| 15 | Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection显示文摘 | Rodems SM Spector DH | 1998 | J Virol1998，72，11： | 1 |
| 16 | Heterogeneity in the regenerative abilities of central nervous system axons within species: why do some neurons regenerate better than others?显示文摘Some neurons,especially in mammalian peripheral nervous system or in lower vertebrate or in vertebrate central nervous system(CNS)regenerate after axotomy,while most mammalian CNS neurons fail to regenerate.There is an emerging consensus that neurons have different intrinsic regenerative capabilities,which theoretically could be manipulated therapeutically to improve regeneration.Population-based comparisons between'good regenerating'and'bad regenerating'neurons in the CNS and peripheral nervous system of most vertebrates yield results that are inconclusive or difficult to interpret.At least in part,this reflects the great diversity of cells in the mammalian CNS.Using mammalian nervous system imposes several methodical limitations.First,the small sizes and large numbers of neurons in the CNS make it very difficult to distinguish regenerating neurons from non-regenerating ones.Second,the lack of identifiable neurons makes it impossible to correlate biochemical changes in a neuron with axonal damage of the same neuron,and therefore,to dissect the molecular mechanisms of regeneration on the level of single neurons.This review will survey the reported responses to axon injury and the determinants of axon regeneration,emphasizing non-mammalian model organisms,which are often under-utilized,but in which the data are especially easy to interpret. | William Rodemer Jianli Hu Michael E.Selzer Michael I.Shifman | 2020 | Neural Regeneration Research2020，15，6： | 0 |
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