|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 2 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 3 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 4 | A Portable Algorithm to Retrieve Bottom Depth of Optically Shallow Waters from Top-Of-Atmosphere Measurements显示文摘Bottom depth(H)of optically shallow waters can be retrieved from multiband imagery,where remote sensing reflectance(R_(rs))are commonly used as the input.Because of the difficulties of removing the atmospheric effects in coastal areas,quite often,there are no valid R_(rs) from satellites for the retrieval of H.More importantly,the empirical algorithms for H are hardly portable to new measurements.In this study,using data from Landsat-8 and ICESat-2 as examples,we present an approach to retrieve H directly from the top-of-atmosphere(TOA)data.It not only bypasses the requirement to correct the effects of aerosols but also shows promising portability to areas not included in algorithm development.Specifically,we use Rayleigh-corrected TOA reflectance(ρ_(rc))in the 443–2300nm range as input,along with a multilayer perceptron(MLP^(ρ_(rc))_(H)),for the retrieval of H.More than 78,000 matchup points ofρ_(rc)and H(0–25 m)were used to train MLP^(ρ_(rc))_(H),which resulted in a Mean Absolute Percentage Difference(MARD)of 8.8%and a coefficient of determination(R^(2))of 0.96.This MLP^(ρ_(rc))_(H)was further applied to Landsat-8 data of six regions not included in the training phase,generating MARD and R^(2)values of 8.3%and 0.98,respectively.In contrast,a conventional two-band ratio algorithm with R_(rs) as the input generated MARD and R^(2)values of 31.6%and 0.68 and significantly fewer H retrievals due to failures in atmospheric correction.These results indicate a breakthrough of algorithm portability of MLP^(ρ_(rc))_(H)in sensing H of optically shallow waters. | Wendian Lai Zhongping Lee Junwei Wang Yongchao Wang Rodrigo Garcia Huaguo Zhang | 2022 | Journal of Remote Sensing2022，，1： | 2 |
| 5 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 6 | Prognostic significance of lymphangiogenesis in pharyngolaryn- geal carcinoma patients显示文摘 | Dario Garcia - Carracedo Juan Pablo Rodrigo Aurora Astudillo | 2010 | BMC Cancer2010，10，： | 1 |
| 7 | EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck显示文摘 | Rodrigo LIP Garcia LA Ramos S | 2000 | Clinical Cancer Research2000，6，8： | 1 |
| 8 | EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck 显示文摘 | Rodrigo J P Garcia L A Ramos S | 2000 | Clin Cancer Res2000，6，8： | 1 |
| 9 | Head and neck paragangliomas:revision of 89 cases in 73 patients显示文摘 | Sevilla Garcia MA Liorente Pendas JL Rodrigo Tapia JP | 2007 | Acta Otorrinolaringol Esp2007，58，3： | 1 |
| 10 | Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland 显示文摘 | Rodrigo Antonio Peliciari Garcia Solange Castro Afeche | 2008 | Life Sci2008，，82： | 1 |
| 11 | DNA extraction using Chelex resin for oneogenic amplification analysis in head and neck tumours 显示文摘 | Garcia Gonzalez L A Rodrigo Tapia J P Sanehez Lazo P | 2004 | Acta Otorrinolaringol Esp2004，55，3： | 1 |
| 12 | Factors involved in the effects oflosartan on endothelial dysfunction induced by aging in SHR显示文摘 | Maeso R Rodrigo E Munoz - Garcia R | 1998 | Kindney Int1998，，： | 1 |
| 13 | Factors involved in the effects of Losartan on endothelial dysfunction induced by aging in SHR 显示文摘 | Rodrigo E Munoz Garcia R | 1998 | Kidney Int1998，，： | 1 |
| 14 | System of dynamic neutralization in the lumbar spine : experience on 94 cases 显示文摘 | Bordes - Monmeneu M Bordes - Garcia V Rodrigo - Baeza F | 2005 | Neurocirugia (Astur)2005，16，6： | 1 |
| 15 | Dual effect of l cyclodextrin (/]-CD) on the inhibition of apple polyphenol oxidase by 4-hexylresorcinol (HR) and methyl jas monate (MJ) 显示文摘 | Alvarez-Parrilla E De La Rosa L A Rodrigo Garcia J | 2007 | Food Chemistry2007，101，4： | 1 |
| 16 | Diagnostic value of adenosine deaminase isoenzymes in ascitic fluid显示文摘 | Eloy Fernández Sara Garcia Faustino Gutiérrez Guillermo Ocio Luis Rodrigo Sabino Riestra | 1999 | The American Journal of Gastroenterology1999，，12： | 1 |
| 17 | Channel plasmon polaritons : modal shape, dispersion, and losses显示文摘 | Moreno E Garcia Vidal F J Rodrigo S G | 2006 | Opt Lett2006，31，： | 1 |
| 18 | EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck 显示文摘 | Rodrigo JP Garcia LA Ramos S | 2000 | Clinical Cancer Research2000，6，8： | 1 |
| 19 | The influence on corporate entrepreneurship of technological variables显示文摘 | Martin R Rodrigo Garcia M Victorj Garcia S Encarnacion | | 0，，07： | 1 |
| 20 | Factors involved in the effects of Losartan on endothelial dysfunction induced by aging in SHR显示文摘 | Maeso R RodrigoE Munoz Garcia R | 1998 | Kidney Int1998，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员