|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | In vitro reconstitution of an abscisic acid signalling pathway显示文摘 | FUJII H CHINNUSAMY V RODRIGUES A RUBIO S AATONI R PARK S Y CUTLER S R SHEEN J ROTRIGUES P L ZHU J K | 2009 | Nature2009，462，： | 1 |
| 3 | Spatial and temporal variation of phytoplankton in two subtropical Brazilian reservoirs 显示文摘 | BORGES P A F TRAIN S RODRIGUES L C | 2008 | Hydrobiologia2008，607，： | 1 |
| 4 | Effects of Deficit Irrigation Strategies on Cluster Microclimate for Improving Fruit Composition of Moscatel field-grown Grapevines显示文摘 | Dos Santos T P Lopes C M Rodrigues M L | 2007 | Scientia Horticuhurae2007，112，3： | 1 |
| 5 | Determination of E-2-nonenal by high-performance liquid chromatography with UV detection assay for the evaluation of beer ageing显示文摘 | Santos J R Carneiro J R Guido L F Almeida P J Rodrigues J A Barros A A | 2003 | J Chromatog A2003，985，12： | 1 |
| 6 | Involvement of 5-HT re- ceptors in the antidepressant-like effect of adenosine in the mouse forced swimming test显示文摘 | Kaster M P Santos A' R Rodrigues A L | 2005 | Brain Res Bu112005，67，12： | 1 |
| 7 | High level Escherichla coli expression and production of a bivalent humanized antibody fragment显示文摘 | P Carter R F Kelley M L Rodrigues | 1992 | Nat Biotechnol1992，10，2： | 1 |
| 8 | Death receptors and mitochondria: Two prime triggers of neural apoptosis and dif- ferentiation显示文摘 | Sold S Morgado A L Rodrigues C M P | 2013 | Biochimicaet Biophysica Aeta (BBA) GeneralSubjects2013，1830，1： | 1 |
| 9 | Screening for pharmaceutical cocrystals using the supercritical fiuid enhanced atomization process显示文摘 | Padrela L Rodrigues M A Velaga S P | 2010 | J Supercrit Fluids2010，53，： | 1 |
| 10 | Evalu- ation of the knowledge of health professionals at a pediatric hospital regarding the use of metered - dose inhalers 显示文摘 | Muchao F P Perin S L R R Rodrigues J C | 2008 | Jornal Brasileiro de Pneumologia2008，34，1： | 1 |
| 11 | Flow injection spectrophotometric, determination of A1 in hemodialysis solutions显示文摘 | RODRIGUES J L DE MAGALNAES C S LUCCAS P O | 2005 | J Pharm Biomed Anal2005，36，5： | 1 |
| 12 | Detection of adulteration of commercial honey samples by the 13C/12C isotopic ratio 显示文摘 | PADOVAN G J JONG D D RODRIGUES L P | 2003 | Food Chemistry2003，82，4： | 1 |
| 13 | Synthesis and pharmacological evaluation of novel heterotricyclic aeylhydrazone derivatives, designed as PAF antagonists显示文摘 | FRAGA A G M RODRIGUES C R MIRANDA A L P | 2000 | European Journal of Pharmaceutical Sciences2000，11，： | 1 |
| 14 | Biogenic antimicrobial silver nanoparticles produced by fungi显示文摘 | RODRIGUES A G PING L Y MARCATO P D | 2013 | Applied Microbiology and Biotechnology2013，97，2： | 1 |
| 15 | Impact ofweather regimes on the wind power ramp forecast in Portugal显示文摘 | CoutoA Costa P Rodrigues L | 2015 | IEEE Transactions on Sustainable Energy2015，6，3： | 1 |
| 16 | Volta- mmetric determination of free and total sulfur dioxide inbeer显示文摘 | Almeida P J Rodrigues J A Guido L F | 2003 | Electroanalysis2003，，15： | 1 |
| 17 | New perspectives for citric acid production and application显示文摘 | Soccol C R Vandenberghe L P S Rodrigues C | 2006 | Food Technology and Biotechnology2006，44，2： | 1 |
| 18 | High level Facherichia coli expression and production of a bivalent humanized antibody fragment显示文摘 | Carter P Kelley R F Rodrigues M L | 1992 | Bio Technology1992，10，： | 1 |
| 19 | Two new adjacent bistetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia 显示文摘 | Rodrigues dos Santos Lima L A Santos Pimenta L P Diamantino Boaventure M A | 2009 | Planta Med2009，75，1： | 1 |
| 20 | Neuroinflammation as a possible link between cannabinoids and addiction 显示文摘 | Rodrigues L C Gobira P H de Oliveira A C | 2014 | Acta Neuropsyehiatr2014，26，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员