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| 1 | From blood to breath: New horizons for esophageal cancer biomarkers显示文摘Esophageal cancer is a lethal cancer encompassing adenocarcinoma and squamous cell carcinoma subtypes. The global incidence of esophageal cancer is increasing world-wide, associated with the increased prevalence of associated risk factors. The asymptomatic nature of disease often leads to late diagnosis and five-year survival rates of less than 15%. Current diagnostic tools are restricted to invasive and costly endoscopy and biopsy for histopathology. Minimally and non-invasive biomarkers of esophageal cancer are needed to facilitate earlier detection and better clinical management of patients. This paper summarises recent insights into the development and clinical validation of esophageal cancer biomarkers, focussing on circulating markers in the blood, and the emerging area of breath and odorant biomarkers. | Roger Yazbeck Simone E Jaenisch David I Watson | 2016 | World Journal of Gastroenterology2016，22，46： | 6 |
| 2 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 3 | Physical activity after total knee arthroplasty: A critical review显示文摘Total knee arthroplasty(TKA) is the most commonly performed elective surgery in the United States. TKA typically improves functional performance and reduces pain associated with knee osteoarthritis. Little is known about the influence of TKA on overall physical activity levels. Physical activity, defined as 'any bodily movement produced by skeletal muscles that results in energy expenditure', confers many health benefits but typically decreases with endstage osteoarthritis. The purpose of this review is to describe the potential benefits(metabolic, functional, and orthopedic) of physical activity to patients undergoing TKA, present results from recent studies aimed to determine the effect of TKA on physical activity, and discuss potential sources of variability and conflicting results for physical activity outcomes. Several studies utilizing self-reported outcomes indicate that patients perceive themselves to be more physically active after TKA than they were before surgery. Accelerometry-based outcomes indicate that physical activity for patients after TKA remains at or below pre-surgical levels. Several different factors likely contributed to these variable results, including the use of different instruments, duration of follow-up, and characteristics of the subjects studied. Comparison to norms, however, suggests that daily physical activity for patients following TKA may fall short of healthy agematched controls. We propose that further study of the relationship between TKA and physical activity needs to be performed using accelerometry-based outcome measures at multiple post-surgical time points. | Roger J Paxton Edward L Melanson Jennifer E Stevens-Lapsley Cory L Christiansen | 2015 | World Journal of Orthopedics2015，6，8： | 5 |
| 4 | 用Agilent G1888顶空进样器/6890N气相色谱/5975inert MSD检测系统测定药品中的残留溶剂显示文摘用配置AgilentG1888顶空进样器(HS)和安捷伦5975inert质谱检测器(MSD)的安捷伦6890N气相色谱系统(GC)检测药品中受法规限制的残留溶剂。标准样品混合物的水溶液配制成接近或低于发表的允许溶剂残留水平的不同浓度以评价系统性能。本文的分析包括了国际协调委员会(ICH)指南(包含美国药典方法467中列出的溶剂)中一类和二类溶剂。MSD进行同步选择离子检测/全扫描模式采集选择离子检测与全全扫描的数据,从而对各个被测成组分别进行鉴定与定量。测定了27种不同溶剂的方法检出限。 | Roger L Firor Albert E Gudat | 2005 | 卫生研究2005，34，5： | 4 |
| 5 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 6 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 7 | 利用腰围身高比预测有雄激素缺乏症的老年男性体内血清睾酮水平显示文摘老年男性血清睾酮的下降可能部分是由肥胖引起的,但是,还不能确定哪些肥胖相关的参数与睾酮水平最密切相关。我们研究过伴有雄激素缺乏症但健康状况良好的老年男性的年龄、肥胖和睾酮水平的关系。本研究中,我们从社区中募集了54岁以上无痛症或其他严重疾病的非吸烟男性做横向研究分析,测定身高,体重和腰围,并计算体质指数(BMI)和腰围身高比(WHt)。收集两个早上的血液样本,测量总睾酮,性激素结合球蛋白和促黄体激素。计算游离睾酮(cFT)。并对上述指标与肥胖参数之间的关系进行多元线性凹归分析。207名54-86岁之间的男性参与了此次研究。单因素分析结果表明腰围身高比与睾酮和游离睾酮的相关性明显高于体重和腰吲或体质指数。另外,对总睾酮和游离睾酮来说,体重和腰围以及身高都有重要意义(所有的P均小于0.05),身高值中加入体重和腰围值后,导致体重和腰用以及身高的回归系数都增加了,其中腰围呈负相关,身高呈正相关。总之,腰围身高比是预测健康但有雄激素缺乏症的老年男性的睾酮和游离睾酮最好的体质指标。 | Carolyn A Allan Roger E Peverill Boyd JG Strauss Elise A Forbes Robert I McLachlan | 2011 | Asian Journal of Andrology2011，13，3： | 3 |
| 8 | Identification of a novel glucose transporter-like protein-GLUT-12 显示文摘 | Rogers S Macheda M L Docherty S E | 2002 | Am J Physiol Endocrinol Metab2002，282，3： | 2 |
| 9 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 10 | Mutual coupling between finite lengths parallel or angled horizontal earth return conductors显示文摘 | Rogers J E White F J | 1989 | IEEE Trans PWRD1989，4，1： | 2 |
| 11 | Stability and structure of activated macrocyclic ligands with biological applications显示文摘 | Motekaitis R J Rogers B E Reichert D E | 1996 | Inorg Chem1996，35，： | 2 |
| 12 | Muscle morphogenetic protein induces myogenic geneexpression in Swiss-3T3 cells显示文摘 | YOUNG H E ROGERS J J ADKISON L R | 1998 | Wound Rep Reg1998，6，： | 1 |
| 13 | Illustrating the coupled human-environment system for vulnerability analysis three case studies显示文摘 | Turner II BL Roger E K Pamela A M | 2003 | The Proceedings of the National Academy of Sciences2003，14，： | 1 |
| 14 | Export of mercury downstream from reservoirs显示文摘 | Roger S E | 2000 | The Science of the Total Environment2000，260，： | 1 |
| 15 | Surfactant effect on gas hydrate formation显示文摘 | Zhong Y Rogers R E | 2000 | Chemical Engineering Science2000，55，19： | 1 |
| 16 | Effect of metals and other inorganic ions on soil microbial activity:soil dehydrogenase assay as a simple toxicity test显示文摘 | Rogers J E Li S W | 1985 | Bulletin of Environmental Contamination and Toxicology1985，34，： | 1 |
| 17 | Quality management influences on logistics performance显示文摘 | Ronald D Anferson Roger E Jerman Michael R Crum | 1998 | Transpm Res-E (Logistics and Transpm Rev)1998，34，2： | 1 |
| 18 | Pathobiologic responses to stenting 显示文摘 | Edelman E R Rogers C | 1998 | Am J Cardiol1998，81，7： | 1 |
| 19 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 20 | LMls - A fundamental tool in analysis and controller design for discrete linear repetitive proeesses显示文摘 | Galkowski K Rogers E Xu S | 2002 | IEEE Trans on Circuits and Systems - Ⅰ2002，49，6： | 1 |
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