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| 1 | Lean heart: Role of leptin in cardiac hypertrophy and metabolism显示文摘Leptin is an adipokine that has been linked with the cardiovascular complications resulting from obesity such as hypertension and heart disease. Obese patients have high levels of circulating leptin due to increased fat mass. Clinical and population studies have correlated high levels of circulating leptin with the development of cardiac hypertrophy in obesity. Leptin has also been demonstrated to increase the growth of cultured cardiomyocytes. However, several animal studies of obese leptin deficient mice have not supported a role for leptin in promoting cardiac hypertrophy so the role of leptin in this pathological process remains unclear. Leptin is also an important hormone in the regulation of cardiac metabolism where it supports oxidation of glucose and fatty acids. In addition, leptin plays a critical role in protecting the heart from excess lipid accumulation and the formation of toxic lipids in obesity a condition known as cardiac lipotoxicity. This paper focuses on the data supporting and refuting leptin's role in promoting cardiac hypertrophy as well as its important role in the regulation of cardiac metabolism and protection against cardiac lipotoxicity. | Michael E Hall Romain Harmancey David E Stec | 2015 | World Journal of Cardiology2015，7，9： | 7 |
| 2 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 3 | Sexual health and fertility for individuals with inflammatory bowel disease显示文摘The impact of a chronic disease such as inflammatory bowel disease (IBD) on sexual functioning and body image can significantly impair the quality of life of patients. This review considers the sexual and fertility aspects of IBD patients and their daily management. Modern IBD healthcare management should include appropriate communication on sexuality and consider psychological, physiological, and biological issues. Patients with IBD have less children than the general population, and voluntary childlessness is frequent. The most influential factors reported by IBD patients who experience fertility alteration are psychological and surgery-related problems. Pregnancy is a major concern for patients, and any pregnancy for IBD patients should be closely followed-up to keep the chronic disease in a quiescent state. Preconceptional consultation is of great help. | Romain Leenhardt Pauline Riviere Patrick Papazian Isabelle Nion-Larmurier Guillaume Girard David Laharie Philippe Marteau | 2019 | World Journal of Gastroenterology2019，25，36： | 5 |
| 4 | Diuretic and antioxidant activities of the aqueous extract of leaves of Cassia occidentalis(Linn.) in rats显示文摘Objective: To assess the putative diuretic and antioxidant properties of Cassia occidentalis(C. occidentalis) leaves' aqueous extract. Methods: Adult rats were administered with C. occidentalis leaves aqueous extract acutely(24-h) and subchronically(7 d), at doses 80, 160, 240, 320, and 400 mg/kg(per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide(20 mg/kg, i.p.) and hydrochlorothiazide(HCTZ, 20 mg/kg, i.p.). Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose, and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed. Results: The acute administration of C. occidentalis increased the urinary excretion of 107.58% at the higher dose tested, compared to negative control. The reference drugs furosemide and HCTZ induced increases of 84.27 % and 48.05 %, respectively. Acutely, the extract induced Na+ and Cl- elimination, whereas subchronically an increase in K+ elimination was also observed. The extract also improved the kidney function indexes and oxidative stress markers. These effects were dose-dependent and comparable with positive control observations. Conclusions: Our i ndings strongly suggest that C. occidentalis aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension. | Théophile Dimo Fidèle Ntchapda Joseph Barama David Romain Kemeta Azambou Paul Faustin Seke Etet | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 2 |
| 5 | Insulin resistance–associated hepatic iron overload显示文摘 | Michel-Henry Mendler Bruno Turlin Romain Moirand Anne-Marie Jouanolle Thierry Sapey Dominique Guyader Jean-Yves le Gall Pierre Brissot Véronique David Yves Deugnier | 1999 | Gastroenterology1999，，5： | 2 |
| 6 | Comprehensive expression profiling of the pectin methylesterase gene family during silique development in Arabidopsis thaliana显示文摘 | Romain Louvet Emilie Cavel Laurent Gutierrez Stéphanie Guénin David Roger Fran?oise Gillet Fran?ois Guerineau Jér?me Pelloux | 2006 | Planta2006，，4： | 1 |
| 7 | From trime- thylvinylsilane to ZrC- SiC hybrid materials 显示文摘 | DAVID P ROMAIN L SIRINE C | 2011 | Journal of the European Ceramic Society2011，31，： | 1 |
| 8 | The relationship between rainfall and human density and its implications for future water stress in Sub Saharan Africa 显示文摘 | David le Blanc Romain Perez | 2007 | Ecological Economics2007，，： | 1 |
| 9 | The relationship between rainfall and human density and its implications for future water stress in Sub-Saharan Africa显示文摘 | David le Blanc Romain Perez | 2007 | Ecological Economics2007，，2： | 1 |
| 10 | Assessment of STAN S21 fetal heart monitor by medical staff显示文摘 | Sebastien Rault Christophe Vayssiere Emmanuel Roth Eric David Romain Favre Bruno Langer | 2008 | International Journal of Gynecology and Obstetrics2008，，1： | 1 |
| 11 | Phenotypic spectrum of probable and genetically-confirmed idiopathic basal ganglia calcification显示文摘 | Ga?l Nicolas Cyril Pottier Camille Charbonnier Lucie Guyant-Maréchal Isabelle Le Ber Jérémie Pariente Pierre Labauge Xavier Ayrignac Luc Defebvre David Maltête Olivier Martinaud Romain Lefaucheur Olivier Guillin David Wallon Boris Chaumette Philippe Ronde | 2013 | Brain2013，，11： | 1 |
| 12 | Hypericin and photodynamic therapy decreases human pancreatic cancer in vitro and in vivo显示文摘 | Carson D Liu David Kwan Romaine | 2000 | J Surg Res2000，93，1： | 1 |
| 13 | Early verbal fluency decline after STN implantation: Is it a cognitive microlesion effect?显示文摘 | Romain Lefaucheur Stéphane Derrey Olivier Martinaud David Wallon Nathalie Chastan Emmanuel Gérardin Didier Hannequin David Maltête | 2012 | Journal of the Neurological Sciences (-)2012，，1： | 1 |
| 14 | Simulation of networks of spiking neurons: A review of tools and strategies显示文摘 | Romain Brette Michelle Rudolph Ted Carnevale Michael Hines David Beeman James M. Bower Markus Diesmann Abigail Morrison Philip H. Goodman Frederick C. Harris Milind Zirpe Thomas Natschl?ger Dejan Pecevski Bard Ermentrout Mikael Djurfeldt Anders Lansner Ol | 2007 | Journal of Computational Neuroscience2007，，3： | 1 |
| 15 | Extravascular lung water is an independent prognostic factor in patients with acute respiratory distress syndrome*显示文摘 | Mathieu Jozwiak Serena Silva Romain Persichini Nadia Anguel David Osman Christian Richard Jean-Louis Teboul Xavier Monnet | 2013 | Critical Care Medicine2013，，2： | 1 |
| 16 | From trimethylvinylsilane to ZrC-SiC hybrid materials显示文摘 | Pizon David Lucas Romain Sirine Chehaidi | 2011 | Journal of the European Ceramic Society2011，31，14： | 1 |
| 17 | The Complex Nature of Discordant Severe Calcified Aortic Valve Disease Grading显示文摘 | Marie-Annick Clavel David Messika-Zeitoun Philippe Pibarot Shivani R. Aggarwal Joseph Malouf Phillip A. Araoz Hector I. Michelena Caroline Cueff Eric Larose Romain Capoulade Alec Vahanian Maurice Enriquez-Sarano | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 18 | Impact of Aortic Valve Calcification, as Measured by MDCT, on Survival in Patients With Aortic Stenosis显示文摘 | Marie-Annick Clavel Philippe Pibarot David Messika-Zeitoun Romain Capoulade Joseph Malouf Shivani Aggarval Phillip A. Araoz Hector I. Michelena Caroline Cueff Eric Larose Jordan D. Miller Alec Vahanian Maurice Enriquez-Sarano | 2014 | Journal of the American College of Cardiology2014，，： | 1 |
| 19 | Laparoscopic Anterior Rectopexy to the Promontory for Full-Thickness Rectal Prolapse in 175 Consecutive Patients: Short- and Long-term Follow-up显示文摘 | Jean-Luc Faucheron David Voirin Romain Riboud Pierre-Alexandre Waroquet Jerome Noel | 2012 | Diseases of the Colon & Rectum2012，，6： | 1 |
| 20 | Early inhibition of hepatocyte innate responses by hepatitis B virus显示文摘 | Souphalone Luangsay Marion Gruffaz Nathalie Isorce Barbara Testoni Maud Michelet Suzanne Faure-Dupuy Sarah Maadadi Malika Ait-Goughoulte Romain Parent Michel Rivoire Hassan Javanbakht Julie Lucifora David Durantel Fabien Zoulim | 2015 | Journal of Hepatology2015，，6： | 1 |
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